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Jochen G Salfeld, Deborah J Allen, Zehra Kaymakcalan, Boris Labkovsky, John A Mankovich, Brian T McGuinness, Andrew J Roberts, Paul Sakorafas, Hendricus R J M Hoogenboom, David Schoenhaut, Tristan J Vaughan, Michael White, Alison J Wilton: Methods for treating rheumatoid arthritis using human antibodies that bind human TNFa. Abbott Biotechnology, McCarter & English, Elizabeth A Hanley Esq, Cristin H Cowles, June 26, 2012: US08206714 (52 worldwide citation)

Human antibodies, preferably recombinant human antibodies, that specifically bind to human tumor necrosis factor α (hTNFα) are disclosed. These antibodies have high affinity for hTNFα (e.g., Kd=10−8 M or less), a slow off rate for hTNFα dissociation (e.g., Koff=10−3 sec−1 or less) and neutralize hTN ...


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Jochen G Salfeld, Deborah J Allen, Hendricus RJM Hoogenboom, Zehra Kaymakcalan, Boris Labkovsky, John A Mankovich, Brian T McGuinness, Andrew J Roberts, Paul Sakorafas, David Schoenhaut, Tristan J Vaughan, Michael White, Alison J Wilton: Human antibodies that bind human TNFa. Lahive & Cockfield, October 25, 2007: US20070249813-A1

Human antibodies, preferably recombinant human antibodies, that specifically bind to human tumor necrosis factor α (hTNFα) are disclosed. These antibodies have high affinity for hTNFα (e.g., Kd=10−8 M or less), a slow off rate for hTNFα dissociation (e.g., Koff=10−3 sec−1 or less) and neutralize hTN ...


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Jochen G Salfeld, Deborah J Allen, Hendricus RJM Hoogenboom, Zehra Kaymakcalan, Boris Labkovsky, John A Mankovich, Brian T McGuinness, Andrew J Roberts, Paul Sakorafas, David Schoenhaut, Tristan J Vaughan, Michael White, Alison J Wilton: HUMAN ANTIBODIES THAT BIND HUMAN TNFa. Lahive & Cockfield Abbott, Floor 30 Suite 3000, June 18, 2009: US20090155205-A1

Human antibodies, preferably recombinant human antibodies, that specifically bind to human tumor necrosis factor α (hTNFα) are disclosed. These antibodies have high affinity for hTNFα (e.g., Kd=10−8 M or less), a slow off rate for hTNFα dissociation (e.g., Koff=10−3 sec−1 or less) and neutralize hTN ...