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Jochen G Salfeld, Deborah J Allen, Hendricus R J M Hoogenboom, Zehra Kaymakcalan, Boris Labkovsky, John A Mankovich, Brian T McGuinness, Andrew J Roberts, Paul Sakorafas, David Schoenhaut, Tristan J Vaughan, Michael White, Alison J Wilton: Human antibodies that bind human TNF.alpha.. BASF Aktiengesellschaft, Catherine J Kara, Elizabeth A Hanley Esq, Lahive & Cockfield, July 18, 2000: US06090382 (278 worldwide citation)

Human antibodies, preferably recombinant human antibodies, that specifically bind to human tumor necrosis factor .alpha. (hTNF.alpha.) are disclosed. These antibodies have high affinity for hTNF.alpha. (e.g., K.sub.d =10.sup.-8 M or less), a slow off rate for hTNF.alpha. dissociation (e.g., K.sub.of ...


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Salfeld Jochen G, Allen Deborah J, Hoogenboom Hendricus R J M, Kaymakcalan Zehra, Labkovsky Boris, Mankovich John A, Mcguinness Brian T, Roberts Andrew J, Sakorafas Paul, Schoenhaut David, Vaughan Tristan J, White Michael, Wilton Alison J: Anticorps humains se fixant au facteur necrosant des tumeurs de type .alpha., Human antibodies that bind human tnf.alpha.. Basf Aktiengesellschaft, Abbott Biotechnology, TORYS, August 14, 1997: CA2243459 (12 worldwide citation)

Human antibodies, preferably recombinant human antibodies, that specifically bind to human tumor necrosis factor .alpha. (hTNF.alpha.) are disclosed. These antibodies have high affinity for hTNF.alpha.(e.g., Kd = 10-8 M or less), a slow off rate for hTNF.alpha. dissociation (e.g., Koff = 10-3sec-1 o ...


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Salfeld Jochen G, Allen Deborah J, Kaymakcalan Zehra, Labkovsky Boris, Mankovich John A, Mcguinness Brian T, Roberts Andrew J, Sakorafas Paul, Hoogenboom Hendricus Rjm, Schoenhaut David, Vaughan Tristan J, White Michael, Wilton Alison J: Anticorps humains se fixant au facteur necrosant des tumeurs de type .alpha., Human antibodies that bind human tnf.alpha.. Basf Aktiengesellschaft, Abbott Biotechnology, TORYS, CA2389943

Human antibodies, preferably recombinant human antibodies, that specifically bind to human tumor necrosis factor .alpha. (hTNF.alpha.) are disclosed. These antibodies have high affinity for hTNF.alpha. (e.g., K d = 10 -8 M or less), a slow off rate for hTNF.alpha. dissociation (e.g., K off = 10 -3se ...