1
Sigal Irving S, Huff Joel R, Darke Paul L, Vacca Joseph P, Young Steven D, Desolms S Jane, Thompson Wayne J, Lyle Terry A, Graham Samuel L, Ghosh Arun K: Hiv protease inhibitors useful for the treatment of aids.. Merck & Co, October 18, 1989: EP0337714-A2 (242 worldwide citation)

Compounds of the form A-G-B-B-J wherein A is an amine protecting group commonly employed in peptide synthesis, G a dipeptide isostere, B an amino acid or analog thereof, and J a small terminal group are described. These compounds are useful in the inhibition of HIV protease, the prevention or treatm ...


2
Desolms S Jane, Huff Joel R, Vacca Joseph P, Sigal Irving S, Darke Paul L, Young Steven D: Hiv protease inhibitors useful for the treatment of aids.. Merck & Co, February 28, 1990: EP0356223-A2 (214 worldwide citation)

Compounds of the form, A-G-B-B-J wherein A is an amine protecting group not useful or commonly employed in peptide synthesis, G a dipeptide isostere, B an amino acid or analog thereof, and J a small terminal group are described. These compounds are useful in the inhibition of HIV protease, the preve ...


3
Joseph P Vacca, Bruce D Dorsey, James P Guare, M Katharine Holloway, Randall W Hungate, Rhonda B Levin: HIV protease inhibitors useful for the treatment of AIDS. Merck & Co, Roy D Meredith, Carol S Quagliato, Charles M Caruso, May 9, 1995: US05413999 (93 worldwide citation)

Compounds of formula ##STR1## where R.sup.1 and R.sup.2 are independently hydrogen or optionally-substituted C.sub.1-4 alkyl or aryl, or R.sup.1 and R.sup.2 are joined together to form a monocyclic or bicyclic ring system, are HIV protease inhibitors. These compounds are useful in the treatment of i ...


4
Vacca Joseph P, Holloway M Katharine, Dorsey Bruce D, Hungate Randall W, Guare James P: Hiv protease inhibitors useful for the treatment of aids.. Merck & Co, May 12, 1993: EP0541168-A1 (75 worldwide citation)

Compounds of formula where R and R are independently hydrogen or optionally-substituted C PI alkyl or aryl, or R and R are joined together to form a monocyclic or bicyclic ring system, are HIV protease inhibitors. These compounds are useful in the prevention or treatment of infection by HIV and in t ...


5
Thompson Wayne J, Vacca Joseph P, Huff Joel R, Lyle Terry A, Young Steven D, Hungate Randall W, Britcher Susan F, Ghosh Arun K: Hiv protease inhibitors useful for the treatment of aids.. Merck & Co, June 26, 1991: EP0434365-A2 (69 worldwide citation)

Compounds of the form, A-G-B-B-J wherein A is an amine protecting group or urethane, G a dipeptide isostere substituted with a basic amine nitrogen, B an amino acid or analog thereof, and J a small terminal group are described. These compounds are useful in the inhibition of HIV protease, the preven ...


6
Ghosh Arun K, Huff Joel R, Thompson Wayne J, Lyle Terry A, Hungate Randall W, Mckee Sean P, Lee Hee Yoon: Hiv protease inhibitors useful for the treatment of aids.. Merck & Co, March 31, 1993: EP0534511-A1 (10 worldwide citation)

Compounds of the form, A-G-J wherein A is an amine protecting group or urethane, G a dipeptide isostere and J a small terminal group are described. They are distinguished by tetrahydrofuryl or tetrahydropyranyl substituents, and the like. These compounds are useful in the inhibition of HIV protease, ...


7
Craig A Coburn, Mark E Fraley, M Katharine Holloway, Randall W Hungate, Kristine Prendergast: HIV protease inhibitors useful for the treatment of AIDS. Merck & Co, Kenneth R Walton, Melvin Winokur, December 8, 1998: US05846978 (9 worldwide citation)

Compounds such as ##STR1## or pharmaceutically acceptable salts thereof, are HIV protease inhibitors. These compounds are useful in the prevention or treatment of infection by HIV and in the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredi ...


8
Randall W Hungate, Joseph P Vacca, Byeong Moon Kim: HIV Protease inhibitors useful for the treatment of AIDS. Merck & Co, Melvin Winokur, Kenneth R Walton, September 22, 1998: US05811462 (6 worldwide citation)

Peptide analogs containing norbornene are HIV protease inhibitors. These compounds are useful in the prevention or treatment of infection by HIV and in the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination ...


9
Joseph P Vacca, Bruce D Dorsey, James P Guare, M Katharine Holloway, Randall W Hungate, Rhonda B Levin: HIV protease inhibitors useful for the treatment of AIDS. Merck & Co, Roy D Meredith, Jack L Tribble, June 18, 1996: US05527799 (6 worldwide citation)

Compounds of formula ##STR1## where R.sup.1 and R.sup.2 are independently hydrogen or optionally-substituted C.sub.1-4 alkyl or aryl, or R.sup.1 and R.sup.2 are joined together to form a monocyclic or bicyclic ring system, are HIV protease inhibitors. These compounds are useful in the prevention or ...


10
Joel R Huff, Joseph P Vacca, Bruce D Dorsey: HIV protease inhibitors useful for the treatment of AIDS. Merck & Co, Mary A Appollina, Melvin Winokur, July 8, 1997: US05646148 (5 worldwide citation)

Compounds of formula ##STR1## are HIV protease inhibitors. These compounds are useful in the prevention or treatment of infection by HIV and in the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with ot ...