1
Raju Kucherlapati, Aya Jakobovits, Sue Kalpholz, Daniel G Brenner, Daniel J Capon: Generation of xenogeneic antibodies. Abgenix, James F Haley Jr Esq, Jane T Gunnison Esq, Fish & Neave, September 5, 2000: US06114598 (335 worldwide citation)

The subject invention provides non-human mammalian hosts characterized by inactivated endogenous Ig loci and functional human Ig loci for response to an immunogen to produce human antibodies or analogs thereof. The hosts are produced by multiple genetic modifications of embryonic cells in conjunctio ...


2
Raju Kucherlapati, Aya Jakobovits, Sue Klapholz, Daniel G Brenner, Daniel J Capon: Generation of xenogeneic antibodies. Abgenix, James F Haley Jr, Jane T Gunnison, Fish & Neave, January 6, 2004: US06673986 (131 worldwide citation)

The subject invention provides non-human mammalian hosts characterized by inactivated endogenous Ig loci and functional human Ig loci for response to an immunogen to produce human antibodies or analogs thereof. The hosts are produced by multiple genetic modifications of embryonic cells in conjunctio ...


3
Kucherlapati Raju, Jakobovits Aya: Generation of xenogeneic antibodies.. Cell Genesys, January 2, 1992: EP0463151-A1 (119 worldwide citation)

The subject invention provides non-human mammalian hosts characterized by inactivated endogenous Ig loci. The hosts are produced by repetitive transformations of embryonic stem cells by homologous recombination, preferably in conjunction with breeding. Different strategies are employed for recombina ...


4
Kucherlapati Raju, Jakobovits Aya: Generation of xenogeneic antibodies. Cell Genesys, May 8, 1996: EP0710719-A1 (12 worldwide citation)

The subject invention provides non-human mammalian hosts characterized by inactivated endogenous Ig loci and functional human Ig loci for response to an immunogen to produce human antibodies or analogs thereof. The hosts are produced by repetitive transformations of embryonic stem cells by homologou ...


5
Kuncherlapati Raju, Jakobovits Aya, Klapholz Sue, Brenner Daniel G, Capon Daniel J: Generation of xenogeneic antibodies. Cell Genesys, BENZ William H, February 3, 1994: WO/1994/002602 (9 worldwide citation)

The subject invention provides non-human mammalian hosts characterized by inactivated endogenous Ig loci and functional human Ig loci for response to an immunogen to produce human antibodies or analogs thereof. The hosts are produced by multiple genetic modifications of embryonic cells in conjunctio ...


6
Kucherlapati Raju, Jakobovits Aya: Generation of xenogeneic antibodies. Cell Genesys, MURASHIGE Kate H, July 25, 1991: WO/1991/010741 (8 worldwide citation)

The subject invention provides non-human mammalian hosts characterized by inactivated endogenous Ig loci and functional human Ig loci for response to an immunogen to produce human antibodies or analogs thereof. The hosts are produced by repetitive transformations of embryonic stem cells by homologou ...


7
Kucherlapati Raju, Jakobovits Aya: Generation of xenogeneic antibodies. Abgenix, August 16, 2006: EP1690934-A2

The subject invention provides non-human mammalian hosts characterized by inactivated endogenous Ig loci and functional human Ig loci for response to an immunogen to produce human antibodies or analogs thereof. The hosts are produced by repetitive transformations of embryonic stem cells by homologou ...


8
Kucherlapati Raju, Jakobovits Aya: Generation of xenogeneic antibodies. Abgenix, August 16, 2006: EP1690935-A2

The subject invention provides non-human mammalian hosts characterized by inactivated endogenous Ig loci and functional human Ig loci for response to an immunogen to produce human antibodies or analogs thereof. The hosts are produced by repetitive transformations of embryonic stem cells by homologou ...


9
Kuncherlapati Raju, Jakobovits Aya, Klapholz Sue, Brenner Daniel G, Capon Daniel J: Generation of xenogeneic antibodies.. Cell Genesys, May 17, 1995: EP0652950-A1

The subject invention provides non-human mammalian hosts characterized by inactivated endogenous Ig loci and functional human Ig loci for response to an immunogen to produce human antibodies or analogs thereof. The hosts are produced by multiple genetic modifications of embryonic cells in conjunctio ...


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