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SCHRUM Jason, BANCEL Stephane, AFEYAN Noubar B: Acides nucléiques modifiés et leurs procédés dutilisation, Engineered nucleic acids and methods of use thereof. Moderna Therapeutics, SCHRUM Jason, BANCEL Stephane, AFEYAN Noubar B, MCCARTY Catherine M, February 9, 2012: WO/2012/019168 (19 worldwide citation)

Provided are compositions and methods for delivering biological moieties such as modified nucleic acids into cells to modulate protein expression. Such compositions and methods include the use of modified messenger RNAs, and are useful to treat or prevent diseases, disorders or conditions, or to imp ...


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BANCEL Stephane, SCHRUM Jason P: [fr] ACIDES NUCLÉIQUES MODIFIÉS ET LEURS PROCÉDÉS DUTILISATION, [en] ENGINEERED NUCLEIC ACIDS AND METHODS OF USE THEREOF. BANCEL Stephane, SCHRUM Jason P, MODERNA THERAPEUTICS, WARD Donna T, March 21, 2013: WO/2013/039857 (17 worldwide citation)

[en] Provided are compositions and methods for delivering biological moieties such as modified nucleic acids into cells to kill or reduce the growth of microorganisms. Such compositions and methods include the use of modified messenger RNAs, and are useful to treat or prevent microbial infection, or ...


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BANCEL Stephane, SCHRUM Jason P: [fr] ACIDES NUCLÉIQUES MODIFIÉS ET LEURS PROCÉDÉS DUTILISATION, [en] ENGINEERED NUCLEIC ACIDS AND METHODS OF USE THEREOF. BANCEL Stephane, SCHRUM Jason P, MODERNA THERAPEUTICS, WARD Donna T, March 21, 2013: WO/2013/039861 (15 worldwide citation)

[en] Provided are compositions and methods for delivering biological moieties such as modified nucleic acids into cells to kill or reduce the growth of viruses. Such compositions and methods include the use of modified messenger RNAs, and are useful to treat or prevent viral infection, or to improve ...


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SCHRUM Jason, SIECZKIEWICZ Gregory J, EJEBE Kenechi, ELBASHIR Sayda: SYNTHÈSE DACIDES NUCLÉIQUES ET MÉTHODES DUTILISATION ASSOCIÉES, ENGINEERED NUCLEIC ACIDS AND METHODS OF USE THEREOF. SCHRUM Jason, SIECZKIEWICZ Gregory J, EJEBE Kenechi, ELBASHIR Sayda, LU Shihua, April 5, 2012: WO/2012/045082 (11 worldwide citation)

Provided are compositions and methods for delivering biological moieties such as modified nucleic acids into cells to modulate protein expression. Such compositions and methods include the use of modified messenger RNAs, and are useful for production of proteins.


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Jason P Schrum, Stephane Bancel, Noubar B Afeyan: Engineered nucleic acids and methods of use thereof. Moderna Therapeutics, DT Ward PC, Donna T Ward, Jennifer F Bryan, November 10, 2015: US09181319 (8 worldwide citation)

Provided are compositions and methods for delivering biological moieties such as modified nucleic acids into cells to modulate protein expression. Such compositions and methods include the use of modified messenger RNAs, and are useful to treat or prevent diseases, disorders or conditions, or to imp ...


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Stephane Bancel, Jason P Schrum, Alexander Aristarkhov: Engineered nucleic acids and methods of use thereof. Moderna Therapeutics, Wolf Greenfield & Sacks P C, October 11, 2016: US09464124 (4 worldwide citation)

Provided are compositions and methods for delivering biological moieties such as modified nucleic acids into cells to kill or reduce the growth of microorganisms. Such compositions and methods include the use of modified messenger RNAs, and are useful to treat or prevent microbial infection, or to i ...


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Tirtha Chakraborty, Stephane Bancel, Stephen G Hoge, Atanu Roy, Antonin de Fougerolles, Noubar B Afeyan: Terminally modified RNA. ModernaTx, Nelson Mullins Riley & Scarborough, Amy E Mandragouras Esq, March 21, 2017: US09597380

The invention relates to compositions and methods for the manufacture and optimization of modified mRNA molecules via optimization of their terminal architecture.


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Jason P Schrum, Stephane Bancel, Noubar B Afeyan, Kenechi Ejebe: Engineered nucleic acids and methods of use thereof. Moderna Therapeutics, Cooley, Heidi A Erlacher, Lian Ouyang, September 20, 2016: US09447164

Provided are compositions and methods for delivering biological moieties such as modified nucleic acids into cells to modulate protein expression. Such compositions and methods include the use of modified messenger RNAs, and are useful to treat or prevent diseases, disorders or conditions, or to imp ...


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Jason Schrum, Stéphane Bancel, Noubar B Afeyan: Engineered nucleic acids and methods of use thereof. March 15, 2012: US20120065252-A1

Provided are compositions and methods for delivering biological moieties such as modified nucleic acids into cells to modulate protein expression. Such compositions and methods include the use of modified messenger RNAs, and are useful to treat or prevent diseases, disorders or conditions, or to imp ...