61
Graham Beaton, Eric F Fisher: Modified oligonucleotides and intermediates useful in nucleic acid therapeutics. Amgen, Ron K Levy, Steven M Odre, April 29, 1997: US05625050 (254 worldwide citation)

The present invention provides nuclease resistant 3'-carbon modified oligonucleotides that can be used in the field of nucleic acid therapeutics and diagnostics. The modified oligonucleotides of the present invention have at least one modified internucleotide linkage wherein the divalent oxygen moie ...


62
Hans Peter Haar, Gerhard Werner, Dirk Boecker, Armin Lambrecht, Joachim Kastner: Analytical device for in vivo analysis in the body of a patient. Roche Diagnostics, Jill L Woodburn, June 24, 2003: US06584335 (252 worldwide citation)

Analysis device for determining an analyte in vivo in the body of a patient, having a measuring probe with a hollow needle (


63
Phillip D Cook, Gerhard Baschang: Cyclobutyl oligonucleotide surrogates. ISIS Pharmaceuticals, Ciba-Geigy, Woodcock Washburn Kurtz Mackiewicz & Norris, October 25, 1994: US05359044 (249 worldwide citation)

Oligonucleotide surrogates comprising a plurality of cyclobutyl moieties covalently joined by linking moieties are prepared and used as antisense diagnostics and research reagents. Methods of synthesis and use of both the oligonucleotide surrogates and intermediates thereof are disclosed.


64
Joseph S Foos, Peter G Edelman, James E Flaherty, Joseph Berger: Electrochemical sensors. Ciba Corning Diagnostics, Ciba-Geigy, Nicholas I Slepchuk Jr, Arthur S Morgenstern, Judith A Roesler, March 28, 1995: US05401376 (248 worldwide citation)

An electrochemical sensor having a substrate, conductive strips deposited on the substrate, and a layer insulating portions of the conductive strips except those portions which define a working electrode and at least one second electrode. A solid electrolyte contacting the electrodes is covered by a ...


65
Peter M Meserol, Thomas Palmieri: Cuvette. Personal Diagnostics, R Gale Rhodes Jr, October 17, 1989: US04873993 (248 worldwide citation)

Cuvette with or without a lancet secured thereto and extending therefrom for producing skin puncture to produce body fluid of interest, the cuvette is made of optically transparent material and is provided with a shape and a plurality of optical elements such as integrally formed optical elements fo ...


66
Gary T Neel, Douglas E Bell, T Philip Wong, Houston F Voss, Allan Javier Caban, David K Boehm: Systems and methods for blood glucose sensing. Home Diagnostics, Finnegan Henderson Farabow Garrett & Dunner L, September 20, 2005: US06946299 (247 worldwide citation)

A system for measuring a glucose level in a blood sample includes a test strip and a meter. The test strip includes a sample chamber, a working electrode, a counter electrode, fill-detect electrodes, and an auto-on conductor. A reagent layer is disposed in the sample chamber. The auto-on conductor c ...


67
Joel S Douglas, Jeffrey N Roe, Ryszard Radwanski, Brent G Duchon, Michael J Sanchez, Henry M Grage: Disposable element for use in a body fluid sampling device. Mercury Diagnostics, Burns Doane Swecker & Mathis L, April 11, 2000: US06048352 (247 worldwide citation)

A disposable lancing element is adapted for use in a lancing device for making an incision through a user's skin. The lancing element includes a body which defines a longitudinal axis, and has a skin-lancing member projecting from a front end thereof. A capillary tube is mounted in the body in later ...


68
Stanley T Crooke: Oligoribonucleotides for cleaving RNA. ISIS Pharmaceuticals, Woodcock Washburn Kurtz Mackiewicz & Norris, April 27, 1999: US05898031 (245 worldwide citation)

Oligomeric compounds including oligoribonucleotides and oligoribonucleosides are provided that have subsequences of 2-pentoribofuranosyl nucleosides that activate dsRNase. The oligoribonucleotides and oligoribonucleosides can include substituent groups for increasing binding affinity to complementar ...


69
John G Atwood, Albert C Mossa, Lisa M Goven, Fenton Williams, Timothy M Woudenberg, Marcel Margoulies, Robert P Ragusa, Richard Leath, Clive Miles: Thermal cycler for automatic performance of the polymerase chain reaction with close temperature control. The Perkin Elmer Corporation, Davis Hoxie Faithfull & Hapgood, December 12, 1995: US05475610 (244 worldwide citation)

An instrument for performing highly accurate PCR employing a sample block in microtiter tray format. The sample block has local balance and local symmetry. A three zone film heater controlled by a computer and ramp cooling solenoid valves also controlled by the computer for gating coolant flow throu ...


70
Raghbir S Bhullar, Henning Groll, John T Austera, Douglas P Walling, Timothy I Ranney, James L Pauley Jr: Biosensor with code pattern. Roche Diagnostics Corporation, Jill L Woodburn, November 9, 2004: US06814844 (243 worldwide citation)

The present invention relates to a biosensor. The biosensor includes a support substate, an electrically conductive coating positioned on the support substrate, the coating being formed to define electrodes and a code pattern, wherein there is sufficient contrast between the conductive coating and t ...



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