51
Carter Kittrell, Robert M Cothren Jr, Michael S Feld: Spectral diagonostic and treatment system. Massachusetts Institute of Technology, Hamilton Brook Smith & Reynolds, April 19, 1994: US05304173 (281 worldwide citation)

A laser catheter is disclosed wherein optical fibers carrying laser light are mounted in a catheter for insertion into an artery to provide controlled delivery of a laser beam for percutaneous intravascular laser treatment of atherosclerotic disease. A transparent protective shield is provided at th ...


52
David S Breed: System and method for vehicle diagnostics. Automotive Technologies International, Brian Roffe, September 5, 2006: US07103460 (280 worldwide citation)

Method and system for diagnosing whether vehicular components are operating abnormally based on data obtained from sensors arranged on a vehicle. In a training stage, output from the sensors during normal operation of the components is obtained, each component is adjusted to induce abnormal operatio ...


53
Brent E Modzelewski, Steven B Gilmour, G Thomas Roth, Douglas E Bell: Method for determining concentration of an analyte in a test strip. Home Diagnostics, Finnegan Henderson Farabow Garrett & Dunner, April 1, 2003: US06541266 (278 worldwide citation)

The present invention provides a method of measuring an analyte, such as glucose in a fluid sample, such as whole blood, by a reflectance reading device. The method includes making periodic intermediate calculations of analyte level and dynamically ascertaining when an analytical reaction has reache ...


54
Terry Allen Beaty, Lance Scott Kuhn, Vladimir Svetnik, David W Burke: Meter and method of using the meter for determining the concentration of a component of a fluid. Roche Diagnostics Corporation, Barnes & Thornburg, November 11, 2003: US06645368 (276 worldwide citation)

An apparatus and method for determining the concentration of a medically significant component of a biological fluid comprise providing a cell supporting a chemistry which reacts with the medically significant component. Placement of first and second terminals of the cell in contact with first and s ...


55
Abdo A Husseiny: System for prognosis and diagnostics of failure and wearout monitoring and for prediction of life expectancy of helicopter gearboxes and other rotating equipment. Technology International Incorporated, Sixbey Friedman Leedom & Ferguson, May 11, 1993: US05210704 (271 worldwide citation)

A wearout monitor for failure prognostics is a prognosis tool to predict incipient failure in rotating mechanical equipment. The wearout monitor provides maintenance management of a plant or process with information essential to planning preventive maintenance strategies. The monitor also assists in ...


56
Ronald G Sosnowski, William F Butler, Eugene Tu, Michael I Nerenberg, Michael J Heller, Carl F Edman: Methods and procedures for molecular biological analysis and diagnostics. Nanogen, Lyon & Lyon, April 18, 2000: US06051380 (270 worldwide citation)

A self-addressable, self-assembling microelectronic device is designed and fabricated to actively carry out and control multi-step and multiplex molecular biological reactions in microscopic formats. These reactions include nucleic acid hybridizations, antibody/antigen reactions, diagnostics, and bi ...


57
James E Flaherty, Robert B Green, Steven C Lepke, Richard W Mason: Sensor package. Ciba Corning Diagnostics, Judith A Roesler, Arthur S Morgenstern, December 10, 1996: US05582698 (269 worldwide citation)

A solid state, multi-use electrochemical sensor having an electrically nonconductive substrate, a working electrode, and a semi-permeable membrane covering the working electrode. The working electrode includes an electrically conductive material adhered to a portion of the substrate. A first portion ...


58
Graham Beaton, Eric F Fisher: Modified oligonucleotides and intermediates useful in nucleic acid therapeutics. Amgen, Ron K Levy, Steven M Odre, April 29, 1997: US05625050 (264 worldwide citation)

The present invention provides nuclease resistant 3'-carbon modified oligonucleotides that can be used in the field of nucleic acid therapeutics and diagnostics. The modified oligonucleotides of the present invention have at least one modified internucleotide linkage wherein the divalent oxygen moie ...


59
Robert J Nelson, Herbert H Hooper, Alan K Hauser, Sharat Singh, Stephen J Williams, Alexander P Sassi: Microfluidic method for nucleic acid purification and processing. ACLARA Biosciences, Bertram I Rae Venter Law Group P C Rowland, June 13, 2000: US06074827 (263 worldwide citation)

Integrated microfluidic devices comprising at least an enrichment channel and a main electrophoretic flowpath are provided. In the subject integrated devices, the enrichment channel and the main electrophoretic flowpath are positioned so that waste fluid flows away from said main electrophoretic flo ...


60
Hans Peter Haar, Gerhard Werner, Dirk Boecker, Armin Lambrecht, Joachim Kastner: Analytical device for in vivo analysis in the body of a patient. Roche Diagnostics, Jill L Woodburn, June 24, 2003: US06584335 (262 worldwide citation)

Analysis device for determining an analyte in vivo in the body of a patient, having a measuring probe with a hollow needle (