41
Joel R Mitchen: Blood collection and testing method. Safety Diagnostics, Quarles & Brady, May 14, 1991: US05014718 (295 worldwide citation)

A relatively painless method of safely collecting and testing blood comprises piercing a patient's skin, bathing the pierced area with a vehicle liquid and collecting a sample of the vehicle liquid and any blood on a test disk in the apparatus. A novel disposable apparatus for practicing the method ...


42
Richard D Beckert, Mark M Moeller, William S Wong: Vehicle computer system with wireless internet connectivity. Microsoft Corporation, Lee & Hayes PLLC, March 13, 2001: US06202008 (292 worldwide citation)

A vehicle computer system has a housing sized to be mounted in a vehicle dashboard or other appropriate location. A computer is mounted within the housing and executes an open platform, multi-tasking operating system. The computer runs multiple applications on the operating system, including both ve ...


43
Joel S Douglas, Jeffrey N Roe, Henry M Grage: Methods and apparatus for expressing body fluid from an incision. Mercury Diagnostics, Burns Doane Swecker & Mathis L, September 14, 1999: US05951493 (291 worldwide citation)

A sample of a body fluid such as blood or interstitial fluid is obtained from a body by lancing a portion of a user's skin, preferably in an area other than a finger tip, to form an incision. After the needle has been removed from the incision, a force is applied to depress the skin in a manner form ...


44
Christopher P Adams, Stephen Joseph Kron: Method for performing amplification of nucleic acid with two primers bound to a single solid support. Mosaic Technologies, Whitehead Institute for Biomedical Research, Dann Dorfman Herrell and Skillman, June 24, 1997: US05641658 (280 worldwide citation)

This invention features methods and apparatus for performing nucleic acid hybridization and amplification processes on a support. Such methods and apparatus are useful for synthesizing nucleic acid and detecting target nucleic acid for diagnostics and therapeutics.


45
Stanley T Crooke: Oligoribonucleotides and ribonucleases for cleaving RNA. Isis Pharmaceuticals, Woodcock Washburn Kurtz Mackiewicz & Norris, August 22, 2000: US06107094 (279 worldwide citation)

Oligomeric compounds including oligoribonucleotides and oligoribonucleosides are provided that have subsequences of 2'-pentoribofuranosyl nucleosides that activate dsRNase. The oligoribonucleotides and oligoribonucleosides can include substituent groups for increasing binding affinity to complementa ...


46
Piet H C Moerman, Jerome F McAleer, Matthias Stiene: Combined lancet and electrochemical analyte-testing apparatus. Diabetes Diagnostics, March 16, 2004: US06706159 (277 worldwide citation)

An apparatus for detection and quantitation of an electrochemically-detectable analyte, such as glucose, in blood or interstitial fluid includes a meter unit, a lancet and an electrochemical sensor. Of these components, the meter is preferably reusable, while the lancet and the electrochemical senso ...


47
Carlos H Mastrangelo, Piu F Man, James R Webster: Polymer-based micromachining for microfluidic devices. The Regents of the University of Michigan, Medlen & Carroll, October 24, 2000: US06136212 (276 worldwide citation)

The present invention relates to polymer-based micro-electro-mechanical system (MEMS) technology suitable for the fabrication of integrated microfluidic systems, particularly medical and chemical diagnostics system, ink-jet printer head, as well as any devices that requires liquid- or gas-filled cav ...


48
Pierre Trepagnier: Asynchronous fluorescence scan. Argose, Ivor R Elrifi Esq, Christina V Karnakis Esq, Mintz Levin Cohn Ferris Glovsky and Popeo P C, October 28, 2003: US06639668 (276 worldwide citation)

The present invention is directed to asynchronous scanning devices and methods of using asynchronous scanning to acquire fluorescence data from a sample, such as biological tissue, to facilitate diagnosis of the presence or absence of disease or other abnormality in the sample. The present invention ...


49
Dario Cabib, Robert A Buckwald, Zvi Malik, Yuval Garini, Nir Katzir, Dirk G Soeknsen: Spectral bio-imaging methods for biological research, medical diagnostics and therapy. Applied Spectral Imaging, Mark M Friedman, July 21, 1998: US05784162 (270 worldwide citation)

According to the present invention there are provided spectral imaging methods for biological research, medical diagnostics and therapy comprising the steps of (a) preparing a sample to be spectrally imaged; (b) viewing the sample through an optical device, the optical device being optically connect ...


50
Brent E Modzelewski, Steven B Gilmour, G Thomas Roth, Douglas E Bell: Method for determining concentration of an analyte in a test strip. Home Diagnostics, Finnegan Henderson Farabow Garrett & Dunner, April 1, 2003: US06541266 (267 worldwide citation)

The present invention provides a method of measuring an analyte, such as glucose in a fluid sample, such as whole blood, by a reflectance reading device. The method includes making periodic intermediate calculations of analyte level and dynamically ascertaining when an analytical reaction has reache ...



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