41
Martin Gerber, Matthias Essenpreis, Wolfgang Petrich: Subcutaneous analyte sensor. Roche Diagnostics Operations, Sujatha Subramaniam, Roche Diagnostics Operations, October 4, 2005: US06952603 (308 worldwide citation)

Assembly and method for measuring the concentration of an analyte in a biological matrix. The assembly includes an implantable optical-sensing element that comprises a body, and a membrane mounted on the body in a manner such that the membrane and the body define a cavity. The membrane is permeable ...


42
Pierre Trepagnier: Asynchronous fluorescence scan. Argose, Ivor R Elrifi Esq, Christina V Karnakis Esq, Mintz Levin Cohn Ferris Glovsky and Popeo P C, October 28, 2003: US06639668 (305 worldwide citation)

The present invention is directed to asynchronous scanning devices and methods of using asynchronous scanning to acquire fluorescence data from a sample, such as biological tissue, to facilitate diagnosis of the presence or absence of disease or other abnormality in the sample. The present invention ...


43
Curtis A Birnbach: Device for modulating and reflecting electromagnetic radiation employing electro-optic layer having a variable index of refraction. Quantum Diagnostics, Ostrolenk Faber Gerb & Soffen, November 22, 1988: US04786128 (301 worldwide citation)

A multi-layer device for modulating and reflecting light. The device is formed of an electro-optic layer with a variable index of refraction sandwiched between two other layers having a pre-determined index of refraction. An electric field applied across the electro-optic layer controls the index of ...


44
Stanley T Crooke: Oligoribonucleotides and ribonucleases for cleaving RNA. Isis Pharmaceuticals, Woodcock Washburn Kurtz Mackiewicz & Norris, August 22, 2000: US06107094 (299 worldwide citation)

Oligomeric compounds including oligoribonucleotides and oligoribonucleosides are provided that have subsequences of 2'-pentoribofuranosyl nucleosides that activate dsRNase. The oligoribonucleotides and oligoribonucleosides can include substituent groups for increasing binding affinity to complementa ...


45
Joel R Mitchen: Blood collection and testing method. Safety Diagnostics, Quarles & Brady, May 14, 1991: US05014718 (299 worldwide citation)

A relatively painless method of safely collecting and testing blood comprises piercing a patient's skin, bathing the pierced area with a vehicle liquid and collecting a sample of the vehicle liquid and any blood on a test disk in the apparatus. A novel disposable apparatus for practicing the method ...


46
Joel S Douglas, Jeffrey N Roe, Henry M Grage: Methods and apparatus for expressing body fluid from an incision. Mercury Diagnostics, Burns Doane Swecker & Mathis L, September 14, 1999: US05951493 (295 worldwide citation)

A sample of a body fluid such as blood or interstitial fluid is obtained from a body by lancing a portion of a user's skin, preferably in an area other than a finger tip, to form an incision. After the needle has been removed from the incision, a force is applied to depress the skin in a manner form ...


47
Piet H C Moerman, Jerome F McAleer, Matthias Stiene: Combined lancet and electrochemical analyte-testing apparatus. Diabetes Diagnostics, March 16, 2004: US06706159 (289 worldwide citation)

An apparatus for detection and quantitation of an electrochemically-detectable analyte, such as glucose, in blood or interstitial fluid includes a meter unit, a lancet and an electrochemical sensor. Of these components, the meter is preferably reusable, while the lancet and the electrochemical senso ...


48
Dario Cabib, Robert A Buckwald, Zvi Malik, Yuval Garini, Nir Katzir, Dirk G Soeknsen: Spectral bio-imaging methods for biological research, medical diagnostics and therapy. Applied Spectral Imaging, Mark M Friedman, July 21, 1998: US05784162 (285 worldwide citation)

According to the present invention there are provided spectral imaging methods for biological research, medical diagnostics and therapy comprising the steps of (a) preparing a sample to be spectrally imaged; (b) viewing the sample through an optical device, the optical device being optically connect ...


49
Carlos H Mastrangelo, Piu F Man, James R Webster: Polymer-based micromachining for microfluidic devices. The Regents of the University of Michigan, Medlen & Carroll, October 24, 2000: US06136212 (284 worldwide citation)

The present invention relates to polymer-based micro-electro-mechanical system (MEMS) technology suitable for the fabrication of integrated microfluidic systems, particularly medical and chemical diagnostics system, ink-jet printer head, as well as any devices that requires liquid- or gas-filled cav ...


50
Kurt R Linberg, Randy L Merry, Chester G Nelson, William J Plombon: Virtual remote monitor, alert, diagnostics and programming for implantable medical device systems. Medtronic, Girma Wolde Michael, December 24, 2002: US06497655 (284 worldwide citation)

A plurality of co-operative and complementary software programs are implemented in a web-enabled high speed computer system to remotely monitor, manage and modify the operational and functional parameters of a plurality of implanted medical devices (IMDs). The system utilizes virtual electrophysiolo ...