41
Martin Gerber, Matthias Essenpreis, Wolfgang Petrich: Subcutaneous analyte sensor. Roche Diagnostics Operations, Sujatha Subramaniam, Roche Diagnostics Operations, October 4, 2005: US06952603 (300 worldwide citation)

Assembly and method for measuring the concentration of an analyte in a biological matrix. The assembly includes an implantable optical-sensing element that comprises a body, and a membrane mounted on the body in a manner such that the membrane and the body define a cavity. The membrane is permeable ...


42
Joel R Mitchen: Blood collection and testing method. Safety Diagnostics, Quarles & Brady, May 14, 1991: US05014718 (297 worldwide citation)

A relatively painless method of safely collecting and testing blood comprises piercing a patient's skin, bathing the pierced area with a vehicle liquid and collecting a sample of the vehicle liquid and any blood on a test disk in the apparatus. A novel disposable apparatus for practicing the method ...


43
Christopher P Adams, Stephen Joseph Kron: Method for performing amplification of nucleic acid with two primers bound to a single solid support. Mosaic Technologies, Whitehead Institute for Biomedical Research, Dann Dorfman Herrell and Skillman, June 24, 1997: US05641658 (296 worldwide citation)

This invention features methods and apparatus for performing nucleic acid hybridization and amplification processes on a support. Such methods and apparatus are useful for synthesizing nucleic acid and detecting target nucleic acid for diagnostics and therapeutics.


44
Joel S Douglas, Jeffrey N Roe, Henry M Grage: Methods and apparatus for expressing body fluid from an incision. Mercury Diagnostics, Burns Doane Swecker & Mathis L, September 14, 1999: US05951493 (294 worldwide citation)

A sample of a body fluid such as blood or interstitial fluid is obtained from a body by lancing a portion of a user's skin, preferably in an area other than a finger tip, to form an incision. After the needle has been removed from the incision, a force is applied to depress the skin in a manner form ...


45
Pierre Trepagnier: Asynchronous fluorescence scan. Argose, Ivor R Elrifi Esq, Christina V Karnakis Esq, Mintz Levin Cohn Ferris Glovsky and Popeo P C, October 28, 2003: US06639668 (290 worldwide citation)

The present invention is directed to asynchronous scanning devices and methods of using asynchronous scanning to acquire fluorescence data from a sample, such as biological tissue, to facilitate diagnosis of the presence or absence of disease or other abnormality in the sample. The present invention ...


46
Stanley T Crooke: Oligoribonucleotides and ribonucleases for cleaving RNA. Isis Pharmaceuticals, Woodcock Washburn Kurtz Mackiewicz & Norris, August 22, 2000: US06107094 (288 worldwide citation)

Oligomeric compounds including oligoribonucleotides and oligoribonucleosides are provided that have subsequences of 2'-pentoribofuranosyl nucleosides that activate dsRNase. The oligoribonucleotides and oligoribonucleosides can include substituent groups for increasing binding affinity to complementa ...


47
Piet H C Moerman, Jerome F McAleer, Matthias Stiene: Combined lancet and electrochemical analyte-testing apparatus. Diabetes Diagnostics, March 16, 2004: US06706159 (283 worldwide citation)

An apparatus for detection and quantitation of an electrochemically-detectable analyte, such as glucose, in blood or interstitial fluid includes a meter unit, a lancet and an electrochemical sensor. Of these components, the meter is preferably reusable, while the lancet and the electrochemical senso ...


48
Carlos H Mastrangelo, Piu F Man, James R Webster: Polymer-based micromachining for microfluidic devices. The Regents of the University of Michigan, Medlen & Carroll, October 24, 2000: US06136212 (280 worldwide citation)

The present invention relates to polymer-based micro-electro-mechanical system (MEMS) technology suitable for the fabrication of integrated microfluidic systems, particularly medical and chemical diagnostics system, ink-jet printer head, as well as any devices that requires liquid- or gas-filled cav ...


49
Dario Cabib, Robert A Buckwald, Zvi Malik, Yuval Garini, Nir Katzir, Dirk G Soeknsen: Spectral bio-imaging methods for biological research, medical diagnostics and therapy. Applied Spectral Imaging, Mark M Friedman, July 21, 1998: US05784162 (279 worldwide citation)

According to the present invention there are provided spectral imaging methods for biological research, medical diagnostics and therapy comprising the steps of (a) preparing a sample to be spectrally imaged; (b) viewing the sample through an optical device, the optical device being optically connect ...


50
Carter Kittrell, Robert M Cothren Jr, Michael S Feld: Spectral diagonostic and treatment system. Massachusetts Institute of Technology, Hamilton Brook Smith & Reynolds, April 19, 1994: US05304173 (273 worldwide citation)

A laser catheter is disclosed wherein optical fibers carrying laser light are mounted in a catheter for insertion into an artery to provide controlled delivery of a laser beam for percutaneous intravascular laser treatment of atherosclerotic disease. A transparent protective shield is provided at th ...



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