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Marek Kwiatkowski: Compounds for protecting hydroxyls and methods for their use. Helicos BioSciences Corporation, Cooley Godward Kronish, Thomas C Meyers, October 9, 2007: US07279563 (40 worldwide citation)

A hydrocarbyldithiomethyl-modified compound of the Formula: R1—O—CH2—S—S—R2 or a salt thereof wherein R1 is an organic molecule and R2 is a hydrocarbyl is useful for protecting and/or blocking hydroxyl groups in organic molecules such as nucleotides. The hydrocarbyldithiomethyl-modified compounds ca ...


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Kwiatkowski Marek: Compounds for protecting hydroxyls and methods for their use. Quiatech, July 3, 2002: EP1218391-A1 (40 worldwide citation)

A hydrocarbyldithiomethyl-modified compound of the Formula (1): R-O--CH2-S-S-R, or a salt thereof wherein R is an organic molecule and R is a hydrocarbyl, is useful for protecting and/or blocking hydroxyl groups in organic molecules such as nucleotides. The hydrocarbyldithiomethyl-modified compounds ...


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Kwiatkowski Marek: Compounds for protecting hydroxyls and methods for their use. Quiatech, Kwiatkowski Marek, LINDE Jörgen, April 12, 2001: WO/2001/025247 (1 worldwide citation)

A hydrocarbyldithiomethyl-modified compound of the Formula (1): R?1¿-O--CH¿2?-S-S-R?2¿, or a salt thereof wherein R?1¿ is an organic molecule and R?2¿ is a hydrocarbyl, is useful for protecting and/or blocking hydroxyl groups in organic molecules such as nucleotides. The hydrocarbyldithiomethyl-modi ...


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Kwiatkowski Marek: Composes de protection des hydroxyles et procedes dutilisation, Compounds for protecting hydroxyls and methods for their use. Quiatech, Helicos Biosciences Corporation, ROBIC, June 30, 2009: CA2386221

A hydrocarbyldithiomethyl-modified compound of the Formula (1): R1-O--CH2-S-S-R2, or a salt thereof wherein R1 is an organic molecule and R2 is a hydrocarbyl, is useful for protecting and/or blocking hydroxyl groups in organic molecules such as nucleotides. The hydrocarbyldithiomethyl-modified compo ...


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Marek Kwiatkowski: Compounds for protecting hydroxyls and methods for their use. Quiatech a Swedish corporation, Fish & Richardson PC, September 9, 2004: US20040175726-A1

A hydrocarbyldithiomethyl-modified compound of the Formula: R1—O—CH2—S—S—R2 or a salt thereof wherein R1 is an organic molecule and R2 is a hydrocarbyl is useful for protecting and/or blocking hydroxyl groups in organic molecules such as nucleotides. The hydrocarbyldithiomethyl-modified compounds ca ...


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Marek Kwiatkowski: Compounds for protecting hydroxyls and methods for their use. Chad A Hanson Phd, Fish & Richardson PC PA, February 7, 2002: US20020015961-A1

A hydrocarbyldithiomethyl-modified compound of the Formula: R1—O—CH2—S—S—R2 or a salt thereof wherein R1 is an organic molecule and R2 is a hydrocarbyl is useful for protecting and/or blocking hydroxyl groups in organic molecules such as nucleotides. The hydrocarbyldithiomethyl-modified compounds ca ...


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METHODS FOR SYNTHESIZING NUCLEOTIDE ANALOGUES WITH DISULFIDE LINKERS. May 18, 2017: US20170137869-A1

The present invention provides methods, compositions, mixtures and kits utilizing deoxynucleoside triphosphates comprising a 3′-O position capped by a group comprising methylenedisulfide as a cleavable protecting group and a detectable label reversibly connected to the nucleobase of said deoxynucleo ...


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METHODS OF USING NUCLEOTIDE ANALOGUES. May 18, 2017: US20170137878-A1

The present invention provides methods, compositions, mixtures and kits utilizing deoxynucleoside triphosphates comprising a 3′-O position capped by a group comprising methylenedisulfide as a cleavable protecting group and a detectable label reversibly connected to the nucleobase of said deoxynucleo ...