1
Winzeler Elizabeth, Gray Nathanael S, Han Dong, Cheng Dai: Purine compounds and compositions as kinase inhibitors for the treatment of plasmodium related diseases. Irm, The Scripps Research Institute, Winzeler Elizabeth, Gray Nathanael S, Han Dong, Cheng Dai, REID Scott, August 7, 2008: WO/2008/094737 (45 worldwide citation)

The invention provides a class of purine derivates, pharmaceutical compositions comprising such compounds and the use of such compounds to treat or prevent diseases or disorders associated with kinase activity, particularly malaria.


2
Marsilje Thomas H, Lu Wenshuo, Chen Bei, He Xiaohui, Bursulaya Badry, Lee Christian Cho Hua, Gray Nathanael S: Compounds and compositions as kinase inhibitors. Irm, Marsilje Thomas H, Lu Wenshuo, Chen Bei, He Xiaohui, Bursulaya Badry, Lee Christian Cho Hua, Gray Nathanael S, TONGCO WU Emily, March 12, 2009: WO/2009/032668 (36 worldwide citation)

The invention provides novel pyrimidine derivatives and pharmaceutical compositions thereof, and methods for using such compounds. For example, the pyrimidine derivatives of the invention may be used to treat, ameliorate or prevent a condition which responds to inhibition of insulin-like growth fact ...


3
Jiang Tao, Michellys Pierre Yves, Nguyen Truc Ngoc, Pei Wei, Wu Baogen, Zhu Xuefeng: Compounds and compositions as kinase inhibitors. Irm, Jiang Tao, Michellys Pierre Yves, Nguyen Truc Ngoc, Pei Wei, Wu Baogen, Zhu Xuefeng, TONGO WU Emily, October 15, 2009: WO/2009/126514 (8 worldwide citation)

The invention relates to triazine and pyrimidine derivatives having Formula (1) or (2), and methods for using such compounds. For example, the compounds of the invention may be used to treat, ameliorate or prevent a condition which responds to inhibition of anaplastic lymphoma kinase (ALK) activity, ...


4
Okram Barun, Uno Tetsuo, Ding Qiang, Liu Yahua, Jin Yunho, Jin Qihui, Wu Xu, Che Jianwei, Yan S Frank: Compounds and compositions as kinase inhibitors. Irm, Okram Barun, Uno Tetsuo, Ding Qiang, Liu Yahua, Jin Yunho, Jin Qihui, Wu Xu, Che Jianwei, Yan S Frank, RAYMOND Daniel E, August 6, 2009: WO/2009/097287 (6 worldwide citation)

The invention provides a novel class of 2,7-naphthyridin derivatives; pharmaceutical compositions comprising such compounds and methods of using such compounds to treat o prevent diseases or disorders associated with abnormal or deregulated kinase activity,particulary Syk ZAP70,KDR,FMS,FLT*,c-Kit,RE ...


5
Molteni Valentina, Li Xiaolin, Liu Xiaodong, Chianelli Donatella, Nabakka Juliet, Loren Jon, You Shuli: (haloalkoxy) Phenyl) pyrimidine-2-amine compounds and compositions as kinase inhibitors. Irm, Molteni Valentina, Li Xiaolin, Liu Xiaodong, Chianelli Donatella, Nabakka Juliet, Loren Jon, You Shuli, TONGCO WU Emily, February 26, 2009: WO/2009/026276 (3 worldwide citation)

The invention provides compounds of formula (1) and pharmaceutical compositions thereof, which are useful as protein kinase inhibitors, as well as methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated kinase activity. In some embodiments ...


6
Marsilje Thomas H Iii, Lu Wenshuo, Chen Bei, He Xiaohui, Jiang Songchun, Yang Kunyong: Compounds and compositions as kinase inhibitors. Irm, Marsilje Thomas H Iii, Lu Wenshuo, Chen Bei, He Xiaohui, Jiang Songchun, Yang Kunyong, Tongco Wu Emily, December 30, 2009: WO/2009/158431 (1 worldwide citation)

The invention provides novel pyrimidine derivatives and pharmaceutical compositions thereof, and methods for using such compounds. For example, the pyrimidine derivatives of the invention may be used to treat, ameliorate or prevent a condition which responds to inhibition of insulin-like growth fact ...


7
Matthew T Burger, Savithri Ramurthy, Benjamin R Taft: Compounds and compositions as kinase inhibitors. Novartis, Scott W Reid, November 7, 2017: US09809610

The present invention provides a compound of Formula I: wherein X, Y, Z, R1 and R2 are as described herein, and salts thereof and therapeutic uses of these compounds for treatment of disorders associated with RAF kinase activity. The invention further provides pharmaceutical compositions comprising ...


8
Valentina Molteni, Xiaolin Li, Xiaodong Liu, Donatella Chianelli, Juliet Nabakka, Jon Loren, Shuli You: 5-(4-(haloalkoxy)phenyl) pyrimidine-2-amine compounds and compositions as kinase inhibitors. IRM, Daniel E Raymond, Genomics Institute of the Novartis Research Foundation, October 23, 2012: US08293757

The invention provides compounds of formula (1) and pharmaceutical compositions thereof, which are useful as protein kinase inhibitors, as well as methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated kinase activity. In some embodiments ...


9
Thomas H Marsilje, Wenshuo Lu, Bei Chen, Xiaohui He, Christian Cho Hua Lee, Songchun Jiang, Kunyong Yang: Compounds and compositions as kinase inhibitors. IRM, Emily Tongco Wu, Genomics Institute of the Novartis Research Foundation, October 14, 2014: US08859574

The invention provides novel pyrimidine derivatives and pharmaceutical compositions thereof, and methods for using such compounds. For example, the pyrimidine derivatives of the invention may be used to treat, ameliorate or prevent a condition which responds to inhibition of insulin-like growth fact ...


10
Barun Okram, Tetsuo Uno, Qiang Ding, Yahua Liu, Yunho Jin, Qihui Jin, Xu Wu, Jianwei Che, S Frank Yan, Xueshi Hao: Compounds and compositions as kinase inhibitors. IRM, Daniel E Raymond, Genomics Institute of the Novartis Research Foundation, October 1, 2013: US08546370

The invention provides a novel class of 2,7-naphthyridin derivatives; pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly Syk, ZAP70, KDR, FMS, FLT3, ...