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Jwala Karnik, Clint Carnell, Jesse Rosen, John Allison: Methods and systems for treatment of spasticity. MYOSCIENCE, Kilpatrick Townsend and Stockton, June 6, 2017: US09668800

A system for alleviating spasticity of a skeletal muscle having an associated motor nerve. The system may include a needle probe having at least one needle. The at least one needle has a proximal end, a distal end, and a needle lumen therebetween. The needle is configured for insertion proximate to ...


12
Eli Hatchwell, Peggy S Eis: Methods for detecting a genetic variation in subjects with parkinsonism. POPULATION BIO, Wilson Sonsini Goodrich & Rosati, May 22, 2018: US09976180

This document provides methods and materials related to genetic variations of neurological disorders. For example, this document provides methods for using such genetic variations to assess susceptibility of developing Parkinson's disease.


13
Kevin G Connors, Hung Cao: Delivery system for inflatable implant. AttenueX Technologies, Knobbe Martens Olson & Bear, April 11, 2017: US09615911

An implant delivery system can be used to deliver an implant into a body. The implant delivery system can include an inflation tube and a tubular member surrounding the inflation tube. The inflation tube can be used to provide an inflation medium to the implant. The tubular member can have a distal ...


14
Jonathan Barasch, Andong Qiu: Mutant NGAL proteins and uses thereof. THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, Wilmer Cutler Pickering Hale and Dorr, April 18, 2017: US09624281

In one aspect the present invention is directed to mutant NGAL proteins that have the ability to bind to siderophores, such as enterochelin, and to chelate and transport iron, and that are excreted in the urine. Such NGAL mutants, and complexes thereof with siderophores, can be used to clear excess ...


15
Jan Steyaert, Toon Laeremans, Els Pardon: Chimeric polypeptides comprising G protein-coupled receptors and VHH antibodies. VIB VZW, Vrije Universiteit Brussel, TraskBritt P C, March 14, 2017: US09593157

Described are polypeptides and their use for screening and drug discovery. More specifically, the disclosure provides chimeric polypeptides comprising a membrane protein, in particular a GPCR, fused to a binding domain, wherein the binding domain is directed against and/or specifically binds to the ...


16
Richard J Melker, Donn M Dennis, Jeremy Melker, Mark Rice, Robert Hurley: Intelligent drug and/or fluid delivery system to optimizing medical treatment or therapy using pharmacodynamic and/or pharamacokinetic data. University of Florida Research Foundation Incorporated, Xhale, April 24, 2018: US09950112

A pharmacodynamic (PD), pharmacokinetic (PK), or both and PK guided infusion device, system and method optimizes the safety and efficacy of various forms of treatment or therapy (e.g., drug and/or fluid) in a variety of health-care and other settings.


17
Natasha Faith Cover, Anna K Parsons, Arun Kumar: Device for sterile uterine sampling and drug delivery. University of South Florida, Michele L Lawson, Smith & Hopen P A, August 15, 2017: US09730679

A device and method for the collection of sterile specimen samples from the uterus is presented. Also presented is a method of delivering nano-encapsulated drugs to the female reproductive tract to treat pelvic inflammatory disease. The device generally is comprised of an outer cannula over which a ...


18
Howard E Greene: Infusion delivery devices and methods. Acuity Law Group P C, Daniel M Chambers, May 23, 2017: US09656017

Devices that include multi-reservoir infusion devices and systems for dispensing compositions for the treatment of subjects with an amylin agonist (e.g., the amylin agonist analog, pramlintide), wherein amylin agonists are administered in certain differential bolus and basal ratios to an administere ...


19
Jun Li, Duy Hua, Lateef Uddin Syed, Allan Prior, Luxi Swisher: Electrochemical detection of proteases using AC voltammetry on nanoelectrode arrays. Kansas State University Research Foundation, Hovey Williams, December 26, 2017: US09850520

An electrochemical method for measuring the activity of enzymes using nanoelectrode arrays fabricated with vertically aligned carbon nanofibers. Short peptide substrates specific to disease-related enzymes are covalently attached to the exposed nanofiber tips. A redox moiety, such as ferrocene, can ...


20
Wangyang Tu, Haitang Zhang, Guoji Xu, Jiangtao Chi: Pyridic ketone derivatives, method of preparing same, and pharmaceutical application thereof. Shanghai Hengrui Pharmaceutical, Jiangsu Hengrui Medicine, Panitch Schwarze Belisario & Nadel, March 13, 2018: US09914703

Pyridone derivatives, methods of preparing the pyridone derivatives, and methods of using the pyridone derivatives are provided. In particular, pyridone derivatives of formula (I), and pharmaceutical salts thereof are provided. The pyridone derivatives are useful as mitogen-activated protein kinase ...