31
Michael C Pirrung, J Leighton Read, Stephen P A Fodor, Lubert Stryer: Large scale photolithographic solid phase synthesis of an array of polymers. Affymax Technologies, Kevin R Kaster, Vern Norviel, April 11, 1995: US05405783 (289 worldwide citation)

A technique for the synthesis of arrays of diverse polymers such as polypeptides and nucleic acids. The technique beneficially utilizes solid-phase chemistry techniques. Preferred embodiments utilize photolabile protecting groups, and photolithography. The technique forms polymers with monomer seque ...


32
David R Walt, Karri Lynn Michael: Fiber optic sensor with encoded microspheres. Trustees of Tufts College, Robin M Flehr Hobach Test Albritton and Herbert Silva, February 8, 2000: US06023540 (285 worldwide citation)

A microsphere-based analytic chemistry system is disclosed in which microspheres carrying different chemical functionalities may be mixed together while the ability is retained to identify the functionality on each bead using an optically interrogatable encoding scheme. An optical fiber bundle senso ...


33
David K Wong: Method for measuring glucose. VIA Medical Corporation, December 21, 1993: US05271815 (275 worldwide citation)

This invention provides an electrochemical sensor capable of measuring the glucose level of body fluids, especially blood. More particularly, this invention also relates to the use of such a glucose sensor in an automated bedside blood chemistry system which facilitates the operation of the sensor.


34
Calvin K Li, N Johan Knall, Michael A Vyvoda, James M Cleeves, Vivek Subramanian: Patterning three dimensional structures. Matrix Semiconductor, Blakely Sokoloff Taylor & Zafman, September 30, 2003: US06627530 (272 worldwide citation)

The invention is directed to a method of forming a three dimensional circuit including introducing a three dimensional circuit over a substrate. In one embodiment, the three dimensional circuit includes a circuit structure in a stacked configuration between a first signal line and a second signal li ...


35
Peter C Magnante: Methods and devices to design and fabricate surfaces on contact lenses and on corneal tissue that correct the eyes optical aberrations. July 11, 2000: US06086204 (265 worldwide citation)

Methods and devices are described that are needed to design and fabricate modified surfaces on contact lenses or on corneal tissue that correct the eye's optical aberrations beyond defocus and astigmatism. The invention provides the means for: 1) measuring the eye's optical aberrations either with o ...


36
W Clark Still, Michael H Wigler, Michael H J Ohlmeyer, Lawrence W Dillard, John C Reader: Complex combinatorial chemical libraries encoded with tags. The Trustees of Columbia University in the City of New York, Cold Spring Harbor Laboratory, John P White, October 15, 1996: US05565324 (255 worldwide citation)

Encoded combinatorial chemistry is provided, where sequential synthetic schemes are recorded using organic molecules, which define choice of reactant, and stage, as the same or different bit of information. Various products can be produced in the multi-stage synthesis, such as oligomers and syntheti ...


37
David K Wong, James E Gharib, Kenneth Curry, Luis Retana: Method and apparatus for monitoring blood chemistry. Via Medical Corporation, James R Brueggemann, Sheppard Mullin Richter & Hampton, June 2, 1998: US05758643 (255 worldwide citation)

An improved system is disclosed for monitoring a patient's blood chemistry, wherein the system intermittently draws blood samples from the patient into a special sensor assembly having a plurality of analytical sensors, each sensitive to a particular parameter of the blood. After signals produced by ...


38
Douglas W Walker, Frank M Ordaz, M Terry Olson: Cordless surgical handpiece with disposable battery; and method. Medtronic, Gene W Arant, Larry D Baker, October 3, 2000: US06126670 (249 worldwide citation)

A surgical procedure is disclosed utilizing a cordless surgical handpiece powered from a sterile battery pack that contains a battery in condition for immediate use without further charging or sterilization. The battery chemistry is based upon lithium/manganese dioxide, and the battery after a singl ...


39
Terry Allen Beaty, Lance Scott Kuhn, Vladimir Svetnik, David W Burke: Meter and method of using the meter for determining the concentration of a component of a fluid. Roche Diagnostics Corporation, Barnes & Thornburg, November 11, 2003: US06645368 (249 worldwide citation)

An apparatus and method for determining the concentration of a medically significant component of a biological fluid comprise providing a cell supporting a chemistry which reacts with the medically significant component. Placement of first and second terminals of the cell in contact with first and s ...


40
Joseph P D Angelo, Henry B Schur, Kedu Han, Daniel J Glenn: Integrated system for biological fluid constituent analysis. International Medical Associates, Herbert L Lerner, Laurence A Greenberg, October 31, 1995: US05462064 (248 worldwide citation)

A multi-part system to collect and analyze constituents of body fluid. The use of a multilayered gel matrix to facilitate the collection of analytes fluid and a chemistry detection methodology incorporated into the matrix to aid in the visual or electronic determination of the analyte is described.



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