Michael C Pirrung, J Leighton Read, Stephen P A Fodor, Lubert Stryer: Large scale photolithographic solid phase synthesis of an array of polymers. Affymax Technologies, Kevin R Kaster, Vern Norviel, April 11, 1995: US05405783 (313 worldwide citation)

A technique for the synthesis of arrays of diverse polymers such as polypeptides and nucleic acids. The technique beneficially utilizes solid-phase chemistry techniques. Preferred embodiments utilize photolabile protecting groups, and photolithography. The technique forms polymers with monomer seque ...

David R Walt, Karri Lynn Michael: Fiber optic sensor with encoded microspheres. Trustees of Tufts College, Robin M Flehr Hobach Test Albritton and Herbert Silva, February 8, 2000: US06023540 (306 worldwide citation)

A microsphere-based analytic chemistry system is disclosed in which microspheres carrying different chemical functionalities may be mixed together while the ability is retained to identify the functionality on each bead using an optically interrogatable encoding scheme. An optical fiber bundle senso ...

Douglas W Walker, Frank M Ordaz, M Terry Olson: Cordless surgical handpiece with disposable battery; and method. Medtronic, Gene W Arant, Larry D Baker, October 3, 2000: US06126670 (306 worldwide citation)

A surgical procedure is disclosed utilizing a cordless surgical handpiece powered from a sterile battery pack that contains a battery in condition for immediate use without further charging or sterilization. The battery chemistry is based upon lithium/manganese dioxide, and the battery after a singl ...

David R Walt, Karri L Michael: Target analyte sensors utilizing Microspheres. The Trustees of Tufts College, Robin M Silva, David C Foster, Flehr Hohbach Test Albritton & Herbert, December 4, 2001: US06327410 (303 worldwide citation)

A microsphere-based analytic chemistry system and method for making the same is disclosed in which microspheres or particles carrying bioactive agents may be combined randomly or in ordered fashion and dispersed on a substrate to form an array while maintaining the ability to identify the location o ...

David K Wong: Method for measuring glucose. VIA Medical Corporation, December 21, 1993: US05271815 (299 worldwide citation)

This invention provides an electrochemical sensor capable of measuring the glucose level of body fluids, especially blood. More particularly, this invention also relates to the use of such a glucose sensor in an automated bedside blood chemistry system which facilitates the operation of the sensor.

Calvin K Li, N Johan Knall, Michael A Vyvoda, James M Cleeves, Vivek Subramanian: Patterning three dimensional structures. Matrix Semiconductor, Blakely Sokoloff Taylor & Zafman, September 30, 2003: US06627530 (284 worldwide citation)

The invention is directed to a method of forming a three dimensional circuit including introducing a three dimensional circuit over a substrate. In one embodiment, the three dimensional circuit includes a circuit structure in a stacked configuration between a first signal line and a second signal li ...

Kam S Law, Cissy Leung, Ching C Tang, Kenneth S Collins, Mei Chang, Jerry Y K Wong, David Nin Kou Wang: Reactor chamber self-cleaning process. Applied Materials, Philip A Dalton, October 2, 1990: US04960488 (281 worldwide citation)

A process for cleaning a reactor chamber both locally adjacent the RF electrodes and also throughout the chamber and the exhaust system to the including components such as the throttle valve. Preferably, a two-step continuous etch sequence is used in which the first step uses relatively high pressur ...

Hubert Koster, David M Lough: Beads bound to a solid support and to nucleic acids. Sequenom, Stephanie L Heller Ehrman White & McAuliffe Seidman, October 17, 2000: US06133436 (280 worldwide citation)

Novel compositions comprised of at least one bead conjugated to a solid support and further conjugated to at least one nucleic acid and preferred methods for making the novel compositions are described. As compared to "flat" surfaces, beads linked to a solid support provide an increased surface area ...

Terry Allen Beaty, Lance Scott Kuhn, Vladimir Svetnik, David W Burke: Meter and method of using the meter for determining the concentration of a component of a fluid. Roche Diagnostics Corporation, Barnes & Thornburg, November 11, 2003: US06645368 (279 worldwide citation)

An apparatus and method for determining the concentration of a medically significant component of a biological fluid comprise providing a cell supporting a chemistry which reacts with the medically significant component. Placement of first and second terminals of the cell in contact with first and s ...

Peter C Magnante: Methods and devices to design and fabricate surfaces on contact lenses and on corneal tissue that correct the eyes optical aberrations. July 11, 2000: US06086204 (278 worldwide citation)

Methods and devices are described that are needed to design and fabricate modified surfaces on contact lenses or on corneal tissue that correct the eye's optical aberrations beyond defocus and astigmatism. The invention provides the means for: 1) measuring the eye's optical aberrations either with o ...