21
Peter S Stutman, J Mark Miller: Medical alert distribution system with selective filtering of medical information. Metriplex, Cesari & McKenna, November 19, 1996: US05576952 (399 worldwide citation)

The present invention relates to a medical alert distribution system which receives medical information (e.g. blood pressure, blood chemistry test results, etc.) from monitoring units worn by ambulatory patients. The system also receives medical selection and limit parameters from remote system subs ...


22
Michael P Allen: Disposable electronic assay device. Metrika Laboratories, Timothy H Gens, December 3, 1996: US05580794 (338 worldwide citation)

A disposable electronic assay device comprising card-like housing containing a sample receptor for receiving a sample of body fluid containing an analyte to be determined, a sample treatment element for reaction with sample fluid components to yield a physically detectable change which correlates wi ...


23
William J Dower, Stephen P A Fodor: Sequencing of surface immobilized polymers utilizing microflourescence detection. Affymax Technologies, Townsend & Townsend & Crew, August 20, 1996: US05547839 (329 worldwide citation)

Means for simultaneous parallel sequence analysis of a large number of biological polymer macromolecules. Apparatus and methods may use fluorescent labels in repetitive chemistry to determine terminal monomers on solid phase immobilized polymers. Reagents which specifically recognize terminal monome ...


24
Vadim Vladimirovich Yuzhakov, Faiz Feisal Sherman, Grover David Owens, Vladimir Gartstein: Apparatus and method for using an intracutaneous microneedle array. The Procter & Gamble Company, Bart S Hersko, July 3, 2001: US06256533 (316 worldwide citation)

A microneedle array, constructed of silicon and silicon dioxide compounds or of a molded plastic material, is provided to penetrate the stratum corneum and epidermis layers of skin, but not into the dermis. The microneedles can be used to either dispense a liquid drug, or to sample a body fluid. The ...


25
Satyam C Cherukuri, Robert R Demers, Zhong H Fan, Aaron W Levine, Sterling E McBride, Peter J Zanzucchi: Method and system for inhibiting cross-contamination in fluids of combinatorial chemistry device. David Sarnoff Research Center, William J Burke, February 18, 1997: US05603351 (306 worldwide citation)

A system and method for accomplishing a plurality of combinatorial processes in parallel comprising a microelectronic and fluidic array (device array) having micron-sized reservoirs, connecting microchannels and reaction cells etched into a substrate. The device array is supported by a station which ...


26
Raghuvir Singh, Leslie A Schlain: Fiber-optic probe for the measurement of fluid parameters. Optex Biomedical, April 25, 1995: US05408999 (304 worldwide citation)

A fiber optic sensor suitable for measuring and monitoring fluid parameters, e.g. blood parameters such as carbon dioxide and oxygen partial pressure and hydrogen ion concentration ( pH ). Analyte sensitive chemistry in such probes includes molecules sensitive to responding to an analyte change in a ...


27
John Wallace Parce, Michael R Knapp, Calvin Y H Chow, Luc Bousse: Controlled fluid transport in microfabricated polymeric substrates. Caliper Technologies Corporation, Matthew B Murphy, Jonathan Alan Quine, Townsend and Townsend and Crew, March 23, 1999: US05885470 (297 worldwide citation)

Microfluidic devices are provided for the performance of chemical and biochemical analyses, syntheses and detection. The devices of the invention combine precise fluidic control systems with microfabricated polymeric substrates to provide accurate, low cost miniaturized analytical devices that have ...


28
David M Lough, Hubert Koster: Bead linkers for immobilizing nucleic acids to solid supports. Sequenom, Beth E Arnold, Foley Hoag & Eliot, May 4, 1999: US05900481 (287 worldwide citation)

Novel compositions comprised of at least one bead conjugated to a solid support and further conjugated to at least one nucleic acid and preferred methods for making the novel compositions are described. As compared to "flat" surfaces, beads linked to a solid support provide an increased surface area ...


29
Michael C Pirrung, J Leighton Read, Stephen P A Fodor, Lubert Stryer: Large scale photolithographic solid phase synthesis of an array of polymers. Affymax Technologies, Kevin R Kaster, Vern Norviel, April 11, 1995: US05405783 (283 worldwide citation)

A technique for the synthesis of arrays of diverse polymers such as polypeptides and nucleic acids. The technique beneficially utilizes solid-phase chemistry techniques. Preferred embodiments utilize photolabile protecting groups, and photolithography. The technique forms polymers with monomer seque ...


30
Stephen P A Fodor, Dennis W Solas, William J Dower, Xiaohua C Huang: Oligonucleotides. Affymetrix, Morgan Lewis & Bockius, June 24, 2003: US06582908 (283 worldwide citation)

The present invention provides a number of oligonucleotide sequences which can be used for a wide variety of analyses applicable to the diverse fields impacted by the nature of molecular interaction, including chemistry, biology, medicine, and medical diagnostics. In certain embodiments these oligon ...



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