1
Nishimura Osamu, Fujino Masahiko: Chemically modified lymphokine and production thereof.. Takeda Chemical Industries, September 11, 1985: EP0154316-A2 (337 worldwide citation)

The invention provides chemically modified lymphokines having R &lparstr& O-CH2CH2 &rparstr& n wherein R is a protective group for the terminal oxygen and n is an optional positive integer, bonded directly to at least one primary amino group of the lymphokine moiety, and a method of producing the sa ...


2
Nishimura Osamu, Fujino Masahiko: Lymphokine modifiee par un procede chimique et methode de production, Chemically modified lymphokine and production thereof. Takeda Chemical Industries, FETHERSTONHAUGH & CO, June 13, 1989: CA1255588

Abstract of the DisclosureThe invention provides chemically modified lymphokines havingR?-O-CH2CH2-?n wherein R is a protective group for the terminal oxygen and nis an optional positive integer, bonded directly to at least one primary aminogroup of the lymphokine moiety, and a method of producing t ...


3
Osamu Nishimura, Masahiko Fujino: Chemically modified lymphokine and production thereof. July 1, 1997: USH0001662

The invention provides chemically modified lymphokines comprising a lymphokine moiety and at least one polyethylene glycol moiety of the formula: R.paren open-st.O--CH.sub.2 CH.sub.2 .paren close-st..sub.n wherein R is a protective group for the terminal oxygen and n is at least one, bonded directly ...