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Shinoda Masanobu, Emori Eita, Matsuura Fumiyoshi, Kaneko Toshihiko, Ohi Norihito, Kasai Shunji, Yoshitomi Hideki, Yamazaki Kazuto, Miyashita Sadakazu, Hibara Taro, Seiki Takashi, Clark Richard, Harada Hitoshi: Carboxylic acid derivatives and drugs containing the same. Eisai, June 26, 2002: EP1216980-A1 (25 worldwide citation)

The present invention provides a novel carboxylic acid compound, a salt thereof or a hydrate of them useful as an insulin-resistant improver, and a medicament comprising the compound as an active ingredient. That is, the present invention provides a carboxylic acid compound represented by the follow ...


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Masanobu Shinoda, Eita Emori, Fumiyoshi Matsuura, Toshihiko Kaneko, Norihito Ohi, Shunji Kasai, Hideki Yoshitomi, Kazuto Yamazaki, Sadakazu Miyashita, Taro Hibara, Takashi Seiki, Richard Clark, Hitoshi Harada: Carboxylic acid derivatives and drugs containing the same. Eisai, Birch Stewart Kolasch & Birch, April 26, 2005: US06884821 (23 worldwide citation)

Novel carboxylic acid derivatives of general formula (I), salts of the same, esters thereof, or hydrates of them, which are useful as insulin resistance improvers; and drugs containing the derivatives as the active ingredient. In said formula, R1 is hydrogen, hydroxyl, alkyl, or the like; L is a sin ...


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Kikuchi Kouichi, Tagami Katsuya, Yoshimura Hiroyuki, Hibi Shigeki, Nagai Mitsuo, Abe Shinya, Okita Makoto, Hida Takayuki, Higashi Seiko, Tokuhara Naoki, Kobayashi Seiichi: Heterocyclic carboxylic acid derivatives and drugs containing the same. Eisai, April 29, 1998: EP0838453-A1 (16 worldwide citation)

Described is a heterocycle-containing carboxylic acid derivative represented by the following formula (I): wherein A represents, for example, a heteroaryl group which contains at least one nitrogen atom and may have a substituent, B represents, for example, a heteroarylene group, a -CONH- group or a ...


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Tajima Hisao, Nakayama Yoshisuke, Fukushima Daikichi: Carboxylic acid derivatives and drugs containing the same as the active ingredient. Ono Pharmaceutical Co, January 10, 2001: EP1067109-A1 (13 worldwide citation)

A peroxisome proliferator activated receptor regulator containing a carboxylic acid derivative of formula (I) (wherein all symbols are as defined in the specification), a non-toxic acid thereof or a hydrate thereof as active ingredient. Because of having an effect of regulating PPAR, a compound of f ...


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Tajima Hisao, Nakayama Yoshisuke, Fukushima Daikichi: Carboxylic acid derivatives and drugs containing the same as the active ingredient. Ono Pharmaceutical Co, June 20, 2001: EP1108713-A1 (8 worldwide citation)

A peroxisome proliferator activated receptor regulator containing a carboxylic acid derivative of formula (I) (wherein all symbols are as defined in the specification), a non-toxic acid thereof or a hydrate thereof as active ingredient. Because of having an effect of regulating PPAR, a compound of f ...


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Takuya Seko, Masahiko Terakado, Hiroshi Kohno, Shinya Takahashi: Carboxylic acid derivatives and drugs containing the same as the active ingredient. ONO Pharmaceutical, Sughrue Mion PLLC, February 20, 2007: US07179817 (5 worldwide citation)

Compounds represented by formula (I), prodrugs thereof and salts thereof, and pharmaceutical compositions comprising the same as an active ingredient (wherein each symbol has the meaning as defined in the specification.). Because of having an EDG-1 agonism, the compounds represented by formula (I) a ...


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Tajima Hisao, Nakayama Y, Fukushima D: Carboxylic acid derivatives and drugs containing the same as the active ingredient. Ono Pharmaceutical Co, August 8, 2001: EP1122255-A1 (4 worldwide citation)

A peroxisome proliferator activated receptor regulator containing a compound of formula (I) (wherein all symbols are as defined in the specification), or a salt thereof as active ingredient. Because of having an effect of regulating PPAR, a compound of formula (I) is useful as a hypoglycemic agent, ...