1
John Powell, Duncan Casson, Mark Maginn, Wei Liu, Sandeep Dutta, Andrea Best, Jerry A Hall: Antibodies against nerve growth factor (NGF) with enhanced in vivo stability. Abbott Research, McAndrews Held & Malloy, May 7, 2013: US08435523 (8 worldwide citation)

The present invention provides anti-nerve growth factor (NGF) antibodies that contain an IgG4 constant region comprising a stabilizing hinge region mutation and wherein the antibodies exhibit an unexpectedly long serum half life in cynomolgus monkeys. Pharmaceutical compositions comprising the anti- ...


2
POWELL JOHN: Antibodies against nerve growth factor (ngf) with enhanced in vivo stability. PANGENETICS 110, Woods Geoffrey Corlett, November 11, 2010: WO/2010/128398 (4 worldwide citation)

The present invention provides anti-nerve growth factor (NGF) antibodies that contain an IgG4 constant region comprising a stabilizing hinge region mutation and wherein the antibodies exhibit an unexpectedly long serum half life in cynomolgus monkeys. Pharmaceutical compositions comprising the anti- ...


3

4
John Powell, Duncan Casson, Mark Maginn, Wei Liu, Sandeep Dutta, Andrea Best, Jerry A Hall: Antibodies against nerve growth factor (NGF) with enhanced in vivo stability. McAndrews Held & Malloy, September 20, 2016: US09447181

The present invention provides anti-nerve growth factor (NGF) antibodies that contain an IgG4 constant region comprising a stabilizing hinge region mutation and wherein the antibodies exhibit an unexpectedly long serum half life in cynomolgus monkeys. Pharmaceutical compositions comprising the anti- ...


5
John Powell, Duncan Casson, Mark Maginn, Wei Liu, Sandeep Dutta, Andrea Best, Jerry A Hall: Antibodies against nerve growth factor (ngf) with enhanced in vivo stability. Pangenetics 110, Paul D Yasger, Abbott Laboratories, November 4, 2010: US20100278839-A1

The present invention provides anti-nerve growth factor (NGF) antibodies that contain an IgG4 constant region comprising a stabilizing hinge region mutation and wherein the antibodies exhibit an unexpectedly long serum half life in cynomolgus monkeys. Pharmaceutical compositions comprising the anti- ...


6

7
Powell John, Casson Duncan, Maginn Mark, Liu Wei, Dutta Sandeep, Best Andrea, Hall Jerry A: Antibodies against nerve growth factor (ngf) with enhanced in vivo stability. Pangenetics 110, li chengda, May 16, 2012: CN201080027785

The present invention provides anti-nerve growth factor (NGF) antibodies that contain an IgG4 constant region comprising a stabilizing hinge region mutation and wherein the antibodies exhibit an unexpectedly long serum half life in cynomolgus monkeys. Pharmaceutical compositions comprising the anti- ...


8
Antibodies Against Nerve Growth Factor (NGF) With Enhanced In Vivo Stability. Abbott Research, November 7, 2013: US20130295112-A1

The present invention provides anti-nerve growth factor (NGF) antibodies that contain an IgG4 constant region comprising a stabilizing hinge region mutation and wherein the antibodies exhibit an unexpectedly long serum half life in cynomolgus monkeys. Pharmaceutical compositions comprising the anti- ...