81
Fu Chi Huang, Robert A Galemmo Jr, Henry F Campbell: Quinoline derivatives and use thereof as antagonists of leukotriene D.sub.4. Rorer Pharmaceutical, James A Nicholson, Martin Savitzky, Imre Jim Balogh, April 24, 1990: US04920131 (69 worldwide citation)

This invention relates to quinolinyl compounds of the general formula: ##STR1## and the use of these compounds as pharmacological agents which are lipoxygenase inhibitors and/or leukotriene antagonists possessing anti-inflammatory and anti-allergic properties and their pharmaceutical compositions an ...


82
Colandrea Vincent J, Doherty George A, Hale Jeffrey J, Huo Pei, Legiec Irene E, Toth Leslie, Vachal Petr, Yan Lin: (edg) Receptor agonists. Merck & Co, Colandrea Vincent J, Doherty George A, Hale Jeffrey J, Huo Pei, Legiec Irene E, Toth Leslie, Vachal Petr, Yan Lin, MERCK 126 East Lincoln Avenue Rahway NJ 07065 0907, June 30, 2005: WO/2005/058848 (69 worldwide citation)

The present invention encompasses compounds of Formula A: A as well as the pharmaceutically acceptable salts thereof. The compounds are S1P1/Edg1 receptor agonists and thus have immunosuppressive, anti-inflammatory and hemostatic activities by modulating leukocyte trafficking, sequestering lymphocyt ...


83
Rajashekhar Betageri, Charles L Cywin, Karl Hargrave, Mary Ann Hoermann, Thomas M Kirrane, Thomas M Parks, Usha R Patel, John R Proudfoot, Rajiv Sharma, Sanxing Sun, Xiao Jun Wang: Substituted 1-(4-aminophenyl)pyrazoles and their use as anti-inflammatory agents. Boehringer Ingelheim Pharmaceuticals, Robert P Raymond, Mary Ellen M Devlin, Alan R Stempel, January 14, 2003: US06506747 (68 worldwide citation)

1-(4-aminophenyl)pyrazoles optionally substituted on the 3- and 5-positions of the pyrazole ring and on the amino group at the 4-position of the phenyl ring are disclosed and described, which pyrazoles inhibit IL-2 production in T-lymphocytes.


84
Yie W Chien, Mona Nair: Mucosal adhesive device for long-acting delivery of pharmaceutical combinations in oral cavity. Rutgers The State University of New Jersey, Schwegman Lundberg Woessner & Kluth P A, November 26, 1996: US05578315 (66 worldwide citation)

Mucosal adhesive devices are provided for use in the oral cavity for therapy against infections. The devices are dosage units which comprise a combination of antimicrobial agents such as antifungal agents and anti-inflammatory agents, optionally also a local anesthetic. The dosage units yield a grad ...


85
Mark M Mazumder, Jawahar L Mehta, Malay K Mazumder, Nawab Ali, Steven Trigwell, Rajesh Sharma, Samiran De: Encased stent. Board of Trustees of the University of Arkansas, Ray F Cox Jr, December 25, 2007: US07311727 (64 worldwide citation)

An encased stent that discourages restenosis by having a homogenous endothelial cell lining along the inner wall of the stent. The endothelial cell lining may be coated on the stent before the stent is placed in the artery, or the endothelial cell lining may be grown after placement by several facto ...


86
Lombardo Louis John: Oxime-carbamates and oxime-carbonates as bronchodilators and anti-inflammatory agents.. American Home Prod, February 12, 1992: EP0470805-A1 (64 worldwide citation)

The invention concerns compounds of the formula wherein R is C3-7 alkyl, C3-7 cycloalkyl, R is hydrogen, lower alkyl or a is 1-3; b is 1-3; c is 0-2; X, Y and Z are each independently, a bond, O, S or NH, with the proviso that if one of X or Y is O, S or NH, the other must be a bond; R is amino, low ...


87
Louis J Lombardo: Oxime-carbamates and oxime-carbonates as bronchodilators and anti-inflammatory agents. American Home Products Corporation, George Tarnowski, June 23, 1992: US05124455 (64 worldwide citation)

There are disclosed compounds of the formula ##STR1## wherein R is ##STR2## R.sup.1 is hydrogen, lower alkyl or ##STR3## a is 1-3; b is 1-3;


88
Bagli Jehan Framoz, Lombardo Louis John, Skotnicki Jerauld Stanley: Phenyl pyrazolidinones as bronchodilators and anti-inflammatory agents.. American Home Prod, November 4, 1992: EP0511865-A1 (64 worldwide citation)

There are disclosed compounds of the formula wherein R is hydrogen or lower alkyl; R is C3-7 alkyl or C3-7 cycloalkyl; R is hydrogen, lower alkyl, carboxyloweralkyl, lower alkoxycarbonyl, lower alkoxycarbonyl loweralkyl, aryl , aralkyl, -COOH or CONH2; R is hydrogen, C1-8 alkyl, B is a bond, NH or O ...


89
Piwinski John J, Ganguly Ashit K, Green Michael J, Villani Frank J, Wong Jesse: Benzo(5,6)cycloheptapyridines, compositions and method of use.. Schering, June 15, 1988: EP0270818-A1 (64 worldwide citation)

Derivatives of benzo[5,6]cyclohepta pyridine, and pharmaceutically acceptable salts and solvates thereof are disclosed, which posses anti-allergic and anti-inflammatory activity. Methods for preparing and using the compounds are also described.


90
Fitzi Konrad: 2-Substituted-4(5)-(aryl)-5(4)-(2,3 or -4-pyridyl)-imidazoles. Ciba Geigy Corporation, Kolodny Joseph G, Maitner John J, Groeger Theodore O, December 30, 1975: US3929807 (64 worldwide citation)

Compounds of the formula ##SPC1##Wherein R.sub.1 represents lower alkyl, cycloalkyl or phenyl which is optionally substituted by halogen, lower alkyl or lower alkoxy, and one of the groups R.sub.2 and R.sub.3 represents phenyl which is optionally substituted by halogen, lower alkyl, hydroxy, lower a ...