71
Donald J Eaton, Mary L Moran, Rodney Brenneman: Sinus delivery of sustained release therapeutics. Sinexus, Morrison & Foerster, June 9, 2009: US07544192 (73 worldwide citation)

The invention provides biodegradable implants for treating sinusitis. The biodegradable implants have a size, shape, density, viscosity, and/or mucoadhesiveness that prevents them from being substantially cleared by the mucociliary lining of the sinuses during the intended treatment period. The biod ...


72
Patrick L McGeer, Joseph Rogers, John Sibley, Edith McGeer: Anti-rheumatoid arthritic drugs in the treatment of dementia. Barrigar & Oyen, March 9, 1993: US05192753 (73 worldwide citation)

This invention pertains to the novel use of anti-rheumatoid arthritic drugs in the treatment of dementia. A method of treating dementia in human beings which comprises administering to the human being a therapeutic amount of a non-steroidal anti-inflammatory drug (NSAID) which has the ability to inh ...


73
Jeffrey Askanazi, David P Katz, Tuula Manner: Methods and compositions for treating acute or chronic pain and drug addiction. Aminotek Sciences, Elizabeth M Barnhard, October 26, 1993: US05256669 (71 worldwide citation)

Methods and compositions for treating acute or chronic pain in a mammal comprising administering a therapeutically effective amount of an analgesic solution comprising at least one branched chain amino acid selected from the group consisting of leucine, isoleucine, and valine, or administering a the ...


74
Eugen Harri, Artur Ruegger: Organic compounds. Sandoz, Gerald D Sharkin, Robert S Honor, Thomas O McGovern, September 26, 1978: US04117118 (71 worldwide citation)

This invention provides new antibiotics produced by cultivating a strain of the fungus species, Cylindrocarpon lucidum Booth or Tolypocladium inflatum Gams in contact with a nutrient medium, the antibiotics being useful anti-inflammatory and immunosuppressive agents.


75
John J Piwinski, Michael J Green, Jesse Wong: Heterocyclic n-oxide derivatives of substituted benzo[5,6]cycloheptapyridines, compositions and methods of use. Schering Corporation, James R Nelson, September 29, 1992: US05151423 (70 worldwide citation)

Heterocyclic N-oxide derivatives of substituted benzo[5,6]cycloheptapyridines, and pharmaceutically acceptable salts and solvates thereof are disclosed, which possess anti-allergic and anti-inflammatory activity. Methods for preparing and using the compounds are also described.


76
Joseph M Muchowski, Arthur F Kluge: 5-Aroyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivatives and process for the production thereof. Syntex, Gerard A Blaufarb, May 16, 1978: US04089969 (70 worldwide citation)

Novel 5-aroyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid compounds represented by the formula ##STR1## and the pharmaceutically acceptable, non-toxic esters and salts thereof, wherein R is hydrogen or a lower alkyl group containing from 1 to 4 carbon atoms and R.sup.1 is hydrogen, a lowe ...


77
Thomas Newmark, Paul Schulick: Anti-inflammatory, sleep-promoting herbal composition and method of use. Patton Bogg, May 21, 2002: US06391346 (70 worldwide citation)

An orally administered composition capable of reducing inflammation in animals, preferably humans, while promoting sleep for such animals, contains a therapeutically effective amount of a post-supercritical carbon dioxide hydroalcoholic extract of ginger, therapeutically effective amounts of supercr ...


78
Donald L Bissett, Rodney D Bush, Ranjit Chatterjee: Photoprotection compositions comprising chelating agents. The Procter & Gamble Company, Milton B Graff, David L Suter, Jerry J Yetter, January 30, 1996: US05487884 (69 worldwide citation)

The present invention involves photoprotective compositions which are useful for topical application to prevent damage to skin caused by acute or chronic exposure to ultraviolet light comprising chelating agents. Also involved are compositions comprising chelating agents together with anti-inflammat ...


79
Steven R Jefferies, James L Gutmann, Barry M Heatfield: Collagen-enzyme conjugates that exhibit no inflammatory response and method for making the same. Cushman Darby & Cushman, October 11, 1983: US04409332 (69 worldwide citation)

Collagen polymers are rendered non-inflammatory by complexation with alkaline phosphatase according to the procedure disclosed. Applications of these non-inflammatory collagen complexes include the production of non-inflammatory collagen sutures, collagen soft tissue replacements including wound and ...


80
Janet L Rideout, Thomas A Krenitsky: Process for producing deoxyribosides using bacterial phosphorylase. Burroughs Wellcome Co, Donald Brown, April 26, 1983: US04381344 (69 worldwide citation)

The novel compounds 3-deaza-2'-deoxyadenosine and certain of its derivatives and their pharmaceutically acceptable salts have anti-inflammatory activity as well as immune response suppression activity. 3-Deaza-2'-deoxyadenosine and certain of its intermediates are synthesized by the enzyme catalyzed ...