Anderson Donald Carroll, Rothlein Robert, Smith Clinton Wayne, Barton Randall Wilbur: Use of icam-1 or its functional derivatives for the treatment of non-specific inflammation.. Baylor College Medicine, Boehringer Ingelheim Pharma, May 10, 1989: EP0314863-A2 (82 worldwide citation)

The invention provides a method for treating inflammation caused by the non-specific defense system of a mammalian subject. Inflammation is treated by providing the subject with an anti-inflammatory agent capable of inhibiting granulocyte-endothelial cell adhesion.

Alejandro A Aruffo, Diane Hollenbaugh, Anthony W Siadak, Karen K Berry, Linda Harris, Barbara A Thorne, Jurgen Bajorath: Antibodies against human CD40. Bristol Myers Squibb Co, Christopher A Klein, Audrey F Sher, April 18, 2000: US06051228 (81 worldwide citation)

The Applicants have discovered a novel antibody, more specifically a chimerized anti-human CD40 monoclonal antibody, which blocks the interaction between gp39 and CD40. The anti-CD40 antibodies of the present invention are effective in modulating humoral immune responses against T cell-dependent ant ...

Raffa Robert B: Composition comprising a tramadol material and a non-steroidal anti-inflammatory drug.. Mcneilab, June 16, 1993: EP0546676-A1 (81 worldwide citation)

This invention relates to a composition comprising a tramadol material and a nonsteroidal antiinflammatory drug, and its use. The compositions are pharmacologically useful in treating pain and tussive conditions. The compositions are also subject to less opioid side-effects such as abuse liability, ...

Bret A Ferree: Treating degenerative disc disease through the transplantation of dehydrated tissue. Gifford Krass Groh Sprinkle Anderson & Citkowski PC, November 18, 2003: US06648918 (80 worldwide citation)

A method of treating a diseased or traumatized intervertebral disc is based upon the transplantation of one or more dehydrated biologic tissues into the disc space. In the preferred embodiment, dehydrated nucleus pulposis tissue is used, which may be combined with live nucleus cells. The dehydration ...

John T Dingle, John L Gordon, Geraint Jones, Clive G Knight, John S Lowe: Pharmaceutical compositions. Imperial Chemical, National Research Development Corporation, Cushman Darby & Cushman, January 24, 1984: US04427649 (78 worldwide citation)

Pharmaceutical liposome compositions containing an anti-inflammatory steroid derivative bearing a lipophilic substituent, for example cortisol 21-hexadecanoate. Method of treatment of inflammation at a site involving an enclosed cavity, for example the treatment of rheumatic disease, comprising inje ...

James C Powers, Bogdan Boduszek, Jozef Oleksyszyn: Proline phosphonate derivatives. Georgia Tech Research, DeVeau Colton & Marquis, August 6, 1996: US05543396 (77 worldwide citation)

Peptidyl derivatives of diesters of .alpha.-aminoalkylphosphonic acids, particularly those with proline or related structures, their use in inhibiting serine proteases with chymotrypsin-like, trypsin-like, elastase-like, and dipeptidyl peptidase IV specificity and their roles as anti-inflammatory ag ...


Alain Martin, Sau Hung S Leung: Bioadhesive-wound healing compositions and methods for preparing and using same. Warner Lambert Company, Jean B Barish, August 19, 1997: US05658956 (75 worldwide citation)

The present invention pertains to therapeutic bioadhesive-wound healing compositions useful for treating wounds and increasing the proliferation and resuscitation rate of mammalian cells. The compositions comprise a bioadhesive agent and a therapeutically effective amount of a wound healing composit ...

Renee Kaswan: Ocular cyclosporine composition. University of Georgia Research Foundation, Kilpatrick & Cody, May 2, 1995: US05411952 (75 worldwide citation)

Cyclosporine compositions for topical ophthalmic use for treatment of immune disorders, to enhance or restore tear production, and to enhance or effect normal healing of the surface of the eye, containing cyclosporine dissolved in corn oil. The composition may further include antioxidants, lubricant ...

Kenichi Iwamitsu, Yukio Nakamura, Masahiro Kawasaki, Yoshio Fukui: Combined anti-inflammatory agent. Nissho Corporation, Varndell Legal Group, March 10, 1992: US05095037 (74 worldwide citation)

A pharmaceutical composition for treating inflammatory diseases, comprising (A) an effective amount of hyaluronic acid or its salt, and (B) an effective amount of an anti-inflammatory agent. The composition exhibits a synergistic therapeutic effect on inflammations and is useful for treating inflamm ...