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John T Dingle, John L Gordon, Geraint Jones, Clive G Knight, John S Lowe: Pharmaceutical compositions. Imperial Chemical, National Research Development Corporation, Cushman Darby & Cushman, January 24, 1984: US04427649 (78 worldwide citation)

Pharmaceutical liposome compositions containing an anti-inflammatory steroid derivative bearing a lipophilic substituent, for example cortisol 21-hexadecanoate. Method of treatment of inflammation at a site involving an enclosed cavity, for example the treatment of rheumatic disease, comprising inje ...


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James C Powers, Bogdan Boduszek, Jozef Oleksyszyn: Proline phosphonate derivatives. Georgia Tech Research, DeVeau Colton & Marquis, August 6, 1996: US05543396 (77 worldwide citation)

Peptidyl derivatives of diesters of .alpha.-aminoalkylphosphonic acids, particularly those with proline or related structures, their use in inhibiting serine proteases with chymotrypsin-like, trypsin-like, elastase-like, and dipeptidyl peptidase IV specificity and their roles as anti-inflammatory ag ...


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Timo Haapakumpu, Harri Jukarainen, Juha Ala Sorvari, Henry Rankonen, Frederik E Riphagen, Wolfgang Arnold: Otorhinological delivery device. Schering Oy, James C Lydon, November 13, 2007: US07294345 (76 worldwide citation)

The invention relates to an otorhinological delivery device comprising at least one pharmaceutically active agent. According to the invention the device comprises a core comprising said at least one pharmaceutically active agent wherein said core is made of an elastomer composition selected from the ...


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Alejandro A Aruffo, Diane Hollenbaugh, Anthony W Siadak, Karen K Berry, Linda Harris, Barbara A Thorne, Jurgen Bajorath: Antibodies against human CD40. Bristol Myers Squibb Co, Christopher A Klein, Audrey F Sher, April 18, 2000: US06051228 (73 worldwide citation)

The Applicants have discovered a novel antibody, more specifically a chimerized anti-human CD40 monoclonal antibody, which blocks the interaction between gp39 and CD40. The anti-CD40 antibodies of the present invention are effective in modulating humoral immune responses against T cell-dependent ant ...


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Kenichi Iwamitsu, Yukio Nakamura, Masahiro Kawasaki, Yoshio Fukui: Combined anti-inflammatory agent. Nissho Corporation, Varndell Legal Group, March 10, 1992: US05095037 (73 worldwide citation)

A pharmaceutical composition for treating inflammatory diseases, comprising (A) an effective amount of hyaluronic acid or its salt, and (B) an effective amount of an anti-inflammatory agent. The composition exhibits a synergistic therapeutic effect on inflammations and is useful for treating inflamm ...


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Renee Kaswan: Ocular cyclosporine composition. University of Georgia Research Foundation, Kilpatrick & Cody, May 2, 1995: US05411952 (72 worldwide citation)

Cyclosporine compositions for topical ophthalmic use for treatment of immune disorders, to enhance or restore tear production, and to enhance or effect normal healing of the surface of the eye, containing cyclosporine dissolved in corn oil. The composition may further include antioxidants, lubricant ...


68
Patrick L McGeer, Joseph Rogers, John Sibley, Edith McGeer: Anti-rheumatoid arthritic drugs in the treatment of dementia. Barrigar & Oyen, March 9, 1993: US05192753 (72 worldwide citation)

This invention pertains to the novel use of anti-rheumatoid arthritic drugs in the treatment of dementia. A method of treating dementia in human beings which comprises administering to the human being a therapeutic amount of a non-steroidal anti-inflammatory drug (NSAID) which has the ability to inh ...


69
Bret A Ferree: Treating degenerative disc disease through the transplantation of dehydrated tissue. Gifford Krass Groh Sprinkle Anderson & Citkowski PC, November 18, 2003: US06648918 (72 worldwide citation)

A method of treating a diseased or traumatized intervertebral disc is based upon the transplantation of one or more dehydrated biologic tissues into the disc space. In the preferred embodiment, dehydrated nucleus pulposis tissue is used, which may be combined with live nucleus cells. The dehydration ...


70
Willson H Burgess, Howard P Greisler, William N Drohan, Thomas Maciag, Martin J MacPhee: Method of preparing a tissue sealant-treated biomedical material. Loyola University of Chicago, The American National Red Cross, Sterne Kessler Goldstein & Fox P L L C, May 6, 2003: US06559119 (71 worldwide citation)

This invention provides methods for the preparation of a tissue sealant-treated biomaterial, wherein the tissue sealant used in the method comprises at least one composition which is selected from one or more antibodies, analgesics, anticoagulants, anti-inflammatory compounds, antimicrobial composit ...



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