31
Patrick Aebischer, Lars Wahlberg: Cell culture-containing tubular capsule produced by co-extrusion. Brown University Research Foundation, Thomas J Engellenner, Matthew P Vincent, February 1, 1994: US05283187 (123 worldwide citation)

Living cells such as animal cells which produce biologically active factors are encapsulated within a semipermeable, polymeric membrane such as polyacrylate by co-extruding an aqueous cell suspension and a polymeric solution through a common port having at least one concentric bores to form a tubula ...


32
Duncan H Haynes: Phospholipid-coated microcrystals: injectable formulations of water-insoluble drugs. Nixon & Vanderhye, February 25, 1992: US05091188 (123 worldwide citation)

Water-insoluble drugs are rendered injectable by formulation as aqueous suspensions of phospholipid-coated microcrystals. The crystalline drug is reduced to 50 nm to 10 .mu.m dimensions by sonication or other processes inducing high shear in the presence of phospholipid or other membrane-forming amp ...


33
David J Vachon, Shahram Moaddeb: Implantable stimulation lead having an advanceable therapeutic drug delivery system. Pacesetter, November 10, 1998: US05833715 (123 worldwide citation)

A pacing lead having a stylet introduced anti-inflammatory drug delivery element advanceable from the distal tip electrode. The element is preferably formed as a moldable biocompatible composite material. The element has a biocompatible matrix material which may be combined with drugs and therapeuti ...


34
Bret A Ferree: Treating degenerative disc disease through transplantion of extracellular nucleus pulposus matrix and autograft nucleus pulposus cells. Gifford Krass Groh Sprinkle Anderson & Citkowski PC, March 5, 2002: US06352557 (119 worldwide citation)

Living nucleus pulposus cells are combined with nucleus pulposus extracellular matrix obtained from recently deceased human or animal donors to restore disc function and eliminate pain in patients with disc disease. In the preferred embodiment, the engineered nucleus is morselized to allow insertion ...


35
Bret A Ferree: Treating degenerative disc disease with harvested disc cells and analogues of the extracellular matrix. Gifford Krass Groh Sprinkle Anderson & Citkowski PC, January 22, 2002: US06340369 (119 worldwide citation)

Living intervertebral disc cells are harvested, cultured and combined with type-specific collagen-glycosaminoglycan extracellular matrix analogues to restore disc function and eliminate pain in patients with disc disease. In the preferred embodiment, the engineered disc tissue is morselized to allow ...


36
Miles A Galin: Medicament coated intraocular lens. Brumbaugh Graves Donohue & Raymond, December 23, 1980: US04240163 (117 worldwide citation)

An intraocular lens is coated with a compatible medicament, such as an anticoagulant, an anti-inflammatory agent or an anti-complement agent.


37
Thomas R Tice, Danny H Lewis, Donald R Cowsar, Lee R Beck: Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents. The Stolle Research and Development Corporation, Southern Research Institute, Oblon Fisher Spivak McClelland & Maier, September 17, 1985: US04542025 (117 worldwide citation)

An anti-inflammatory agent containing microparticle composition prepared by a process, comprising (a) dissolving or dispersing an anti-inflammatory agent in a solvent and dissolving a biocompatible and biodegradable wall forming material in said solvent; (b) dispersing said solvent containing said a ...


38
William L Hunter, Lindsay S Machan: Compositions and methods for treating or preventing diseases of body passageways. Angiotech Pharmaceuticals, The University of British Columbia, Seed Intellectual Property Law Group PLLC, July 6, 2004: US06759431 (115 worldwide citation)

The present invention provides methods for treating or preventing diseases associated with body passageways, comprising the step of delivering to an external portion of the body passageway a therapeutic agent. Representative examples of therapeutic agents include anti-angiogenic factors, anti-prolif ...


39
Bret A Ferree: Engineered tissue annulus fibrosis augmentation methods and apparatus. Gifford Krass Groh Sprinkle Anderson & Citkowski PC, September 24, 2002: US06454804 (114 worldwide citation)

Living annulus fibrosis cells are combined with annulus fibrosis extracellular matrix obtained from recently deceased human or animal donors to restore disc function and eliminate pain in patients with disc disease. Additional therapeutic substances like culture medium, growth factors, differentiati ...


40
Alain Martin: Sunscreen-wound healing compositions and methods for preparing and using same. Warner Lambert Company, Jean B Barish, October 7, 1997: US05674912 (111 worldwide citation)

The present invention pertains to therapeutic sunscreen-wound healing compositions useful to minimize and treat sunburn damage. The compositions comprise a therapeutically effective amount of (1) a sunscreen agent; (2) an anti-inflammatory; and, (3) a wound healing composition. In one embodiment the ...



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