31
Cameron Black, Joseph A Mancini, Cheuk K Lau, Petpiboon Prasit, Philip J Vickers: 1-aroyl-3-indolyl alkanoic acids and derivatives thereof useful as anti-inflammatory agents. Merck Frosst Canada, Curtis C Panzer, David L Rose, July 25, 1995: US05436265 (131 worldwide citation)

Compounds of the structures shown below are specific inhibitors of cyclooxygenase-2 useful in the treatment of cyclooxygenase-2 mediated disease states such as inflammation, pain and fever, and are non-ulcerogenic. ##STR1##


32
Duncan H Haynes: Phospholipid-coated microcrystals: injectable formulations of water-insoluble drugs. Nixon & Vanderhye, February 25, 1992: US05091188 (129 worldwide citation)

Water-insoluble drugs are rendered injectable by formulation as aqueous suspensions of phospholipid-coated microcrystals. The crystalline drug is reduced to 50 nm to 10 .mu.m dimensions by sonication or other processes inducing high shear in the presence of phospholipid or other membrane-forming amp ...


33
Patrick Aebischer, Lars Wahlberg: Cell culture-containing tubular capsule produced by co-extrusion. Brown University Research Foundation, Thomas J Engellenner, Matthew P Vincent, February 1, 1994: US05283187 (127 worldwide citation)

Living cells such as animal cells which produce biologically active factors are encapsulated within a semipermeable, polymeric membrane such as polyacrylate by co-extruding an aqueous cell suspension and a polymeric solution through a common port having at least one concentric bores to form a tubula ...


34
Bret A Ferree: Treating degenerative disc disease through transplantion of extracellular nucleus pulposus matrix and autograft nucleus pulposus cells. Gifford Krass Groh Sprinkle Anderson & Citkowski PC, March 5, 2002: US06352557 (125 worldwide citation)

Living nucleus pulposus cells are combined with nucleus pulposus extracellular matrix obtained from recently deceased human or animal donors to restore disc function and eliminate pain in patients with disc disease. In the preferred embodiment, the engineered nucleus is morselized to allow insertion ...


35
Bret A Ferree: Treating degenerative disc disease with harvested disc cells and analogues of the extracellular matrix. Gifford Krass Groh Sprinkle Anderson & Citkowski PC, January 22, 2002: US06340369 (123 worldwide citation)

Living intervertebral disc cells are harvested, cultured and combined with type-specific collagen-glycosaminoglycan extracellular matrix analogues to restore disc function and eliminate pain in patients with disc disease. In the preferred embodiment, the engineered disc tissue is morselized to allow ...


36
Miles A Galin: Medicament coated intraocular lens. Brumbaugh Graves Donohue & Raymond, December 23, 1980: US04240163 (122 worldwide citation)

An intraocular lens is coated with a compatible medicament, such as an anticoagulant, an anti-inflammatory agent or an anti-complement agent.


37
Alain Martin: Sunscreen-wound healing compositions and methods for preparing and using same. Warner Lambert Company, Jean B Barish, October 7, 1997: US05674912 (120 worldwide citation)

The present invention pertains to therapeutic sunscreen-wound healing compositions useful to minimize and treat sunburn damage. The compositions comprise a therapeutically effective amount of (1) a sunscreen agent; (2) an anti-inflammatory; and, (3) a wound healing composition. In one embodiment the ...


38
Bret A Ferree: Engineered tissue annulus fibrosis augmentation methods and apparatus. Gifford Krass Groh Sprinkle Anderson & Citkowski PC, September 24, 2002: US06454804 (119 worldwide citation)

Living annulus fibrosis cells are combined with annulus fibrosis extracellular matrix obtained from recently deceased human or animal donors to restore disc function and eliminate pain in patients with disc disease. Additional therapeutic substances like culture medium, growth factors, differentiati ...


39
Thomas R Tice, Danny H Lewis, Donald R Cowsar, Lee R Beck: Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents. The Stolle Research and Development Corporation, Southern Research Institute, Oblon Fisher Spivak McClelland & Maier, September 17, 1985: US04542025 (118 worldwide citation)

An anti-inflammatory agent containing microparticle composition prepared by a process, comprising (a) dissolving or dispersing an anti-inflammatory agent in a solvent and dissolving a biocompatible and biodegradable wall forming material in said solvent; (b) dispersing said solvent containing said a ...


40
William L Hunter, Lindsay S Machan: Compositions and methods for treating or preventing diseases of body passageways. Angiotech Pharmaceuticals, The University of British Columbia, Seed Intellectual Property Law Group PLLC, July 6, 2004: US06759431 (117 worldwide citation)

The present invention provides methods for treating or preventing diseases associated with body passageways, comprising the step of delivering to an external portion of the body passageway a therapeutic agent. Representative examples of therapeutic agents include anti-angiogenic factors, anti-prolif ...