21
Karl Y Hostetler, Raj Kumar: Method of converting a drug to an orally available form by covalently bonding a lipid to the drug. Vestar, Knobbe Martens Olson & Bear, May 2, 1995: US05411947 (138 worldwide citation)

The oral delivery of many classes of drugs is facilitated by converting drugs having suitable functional groups to 1-O-alkyl-, 1-O-acyl-, 1-S-acyl, and 1-S-alkyl-sn-glycero-3-phosphate derivatives. The method confers the ability to be absorbed through the digestive tract to drugs that are not orally ...


22
Frank Kochinke: Methods and drug delivery systems for the treatment of orofacial diseases. Reed Intellectual Property Law Group, July 11, 2006: US07074426 (136 worldwide citation)

This invention relates to methods of treating various orofacial diseases involving inflammation, infection and/or pain, using intratissue controlled release drug delivery systems. More particularly, the invention relates to methods for localized or targeted administration of a sustained release form ...


23
Akira Ohtori, Masako Andoh, Yasushi Morita: Controlled-release pharmaceutical preparation for intra-ocular implant. Senju Pharmaceutical, Millen White Zelano & Branigan, March 26, 1996: US05501856 (135 worldwide citation)

Presented are a controlled-release pharmaceutical preparation for intra-ocular implant to be applied to the interior of the eye after a surgical operation for disorders in retina/vitreous body or for glaucoma, which is produced by homogeneously dispersing an anti-inflammatory agent or a cell prolife ...


24
Gordon A Elger, Stewart T Leslie, Sandra T A Malkowska, Ronald B Miller, Philip J Neale: Pharmaceutical composition comprising analgesic and anti-inflammatory agent. Euroceltique, Steinberg & Raskin, July 4, 1989: US04844907 (134 worldwide citation)

A pharmaceutical composition in the form of a multiphase (especially a bilayered, optionally coated) tablet. The tablet has a narcotic analgesic phase containing a therapeutically effective quantity of a narcotic analgesic or an analgesically effective salt thereof (e.g. codeine phosphate) and a non ...


25
Sharon Y Buras: Conduit system for directly administering topical anaesthesia to blocked laryngeal-tracheal areas. C Emmett Pugh, September 15, 1987: US04693243 (133 worldwide citation)

A flexible, non-collapsible conduit system separable but positioned around a standard cuffed, endotracheal tube to allow for direct topical application of medicinal substances to tissues of the larynx and trachea that might be irritated, traumatized, or stimulated by the endotracheal tube. An extern ...


26
Cameron Black, Joseph A Mancini, Cheuk K Lau, Petpiboon Prasit, Philip J Vickers: 1-aroyl-3-indolyl alkanoic acids and derivatives thereof useful as anti-inflammatory agents. Merck Frosst Canada, Curtis C Panzer, David L Rose, July 25, 1995: US05436265 (131 worldwide citation)

Compounds of the structures shown below are specific inhibitors of cyclooxygenase-2 useful in the treatment of cyclooxygenase-2 mediated disease states such as inflammation, pain and fever, and are non-ulcerogenic. ##STR1##


27
Warren D Sheffield, Douglas B Johns, Shalaby W Shalaby, Gere S diZerega, LeRoy L Richer: Method for inhibiting post-surgical adhesion formation by the topical administration of non-steroidal anti-inflammatory drug. Ethicon, June 26, 1990: US04937254 (128 worldwide citation)

Postsurgical adhesion formation is inhibited by the topical administration to the site of surgical trauma of a non-steroidal anti-inflammatory drug, preferably ibuprofen, suprofen, or tolmetin.


28
Alain H Shikani, Abraham J Domb: Anti-infective and anti-inflammatory releasing systems for medical devices. Leonard Bloom, June 9, 1998: US05762638 (127 worldwide citation)

Medical devices for implantation into the body are coated with anti-infective and or anti-inflammatory agents. The medical devices can be, for example, endotracheal/tracheostomy tubes and catheters. The devices have a polymer coating containing an anti-infective agent and/or an anti-inflammatory age ...


29
Martin James MacPhee, William Nash Drohan, Gene Liau, Christian Haudenschild: Supplemented and unsupplemented tissue sealants, method of their production and use. The American National Red Cross, Sterne Kessler Goldstein & Fox P L L C, September 12, 2000: US06117425 (126 worldwide citation)

This invention provides supplemented tissue sealants, methods for their production and use thereof. Disclosed are tissue sealants supplemented with at least one cytotoxin or cell proliferation inhibiting composition. The composition may be further supplemented with, for example, one or more antibodi ...


30
David J Vachon, Shahram Moaddeb: Implantable stimulation lead having an advanceable therapeutic drug delivery system. Pacesetter, Malcolm J Romano, September 5, 1995: US05447533 (125 worldwide citation)

A pacing lead having a stylet introduced anti-inflammatory drug delivery element advanceable from the distal tip electrode. The element is preferably formed as a moldable biocompatible composite material. The element has a biocompatible matrix material which may be combined with drugs and therapeuti ...



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