91
Elmer George Roentsch, William Scott Snyder II: Topical formulation for local delivery of a pharmaceutically active agent. William Scott Snyder II, Saliwanchik Lloyd & Saliwanchik, August 5, 1997: US05654337 (63 worldwide citation)

This invention relates to a composition useful in the delivery of pharmaceutically active agents through the skin. In one embodiment of the invention, the composition is formulated with a non-steroidal anti-inflammatory agent, such as ibuprofen or ketoprofen. Such formulation is rapidly absorbed thr ...


92
David T Rovee, John R Marvel, James A Mezick: Topical anti-inflammatory drug therapy. Johnson & Johnson, Irving Newman, January 22, 1980: US04185100 (63 worldwide citation)

A pharmaceutical composition for topical treatment of cutaneous disorders or disruptions characterized by skin inflammation or hyperproliferative epidermal activity comprises the combination of a topically active anti-inflammatory corticosteroid and a non-steroidal anti-inflammatory agent which is a ...


93
John J Piwinski, Ashit K Ganguly, Michael J Green, Frank J Villani, Jesse Wong: 6,11-Dihydro-11-(N-substituted-4-piperidylidene)-5H-benzo(5,6)cyclohepta( 1,2-B)pyridines and compositions and methods of use. Schering Corporation, Henry P Nowak, Richard C Billups, James R Nelson, May 2, 1989: US04826853 (63 worldwide citation)

Derivatives of 6,11-dihydro-11-(4-piperidylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine, and pharmaceutically acceptable salts and solvates thereof are disclosed, which possess anti-allergic and anti-inflammatory activity. Methods for preparing and using the compounds are also described.


94
Abraham Sunshine, Eugene M Laska, Carole E Siegel: Cough/cold mixtures comprising non-steroidal anti-inflammatory drugs. Analgesic Associates, Burns Doane Swecker & Mathis, October 28, 1986: US04619934 (63 worldwide citation)

Pharmaceutical compositions and methods of using same comprising a non-steroidal anti-inflammatory drug in combination with at least one other active component selected from an antihistamine, decongestant, cough suppressant (antitussive) or expectorant are provided for the relief of cough, cold and ...


95
John H Musser, Anthony F Kreft III, Amedeo A Failli, Christopher A Demerson, Uresh S Shah, James A Nelson: Substituted indole-, indene-, pyranoindole- and tetrahydrocarbazole-alkanoic acid derivatives as inhibitors of PLA.sub.2 and lipoxygenase. American Home Products Corporation, George Tarnowski, May 30, 1995: US05420289 (63 worldwide citation)

This invention relates to substituted indole derivatives possessing lipoxygenase inhibitory, phospholipase A.sub.2 inhibitory and leukotriene antagonist activity, which are useful as anti-inflammatory, antiallergic and cytoprotective agents.


96
Michael Schinitsky: Anti-inflammatory composition. Faxon Pharmaceuticals, Barnes & Thornburg, September 25, 1984: US04473551 (63 worldwide citation)

A composition and method for the treatment of disorders having an inflammatory component comprising essentially whole cartilage, or a greater than 100,000 molecular weight fraction obtained from an aqueous extract thereof, in combination with glucosamine or a substance affording glucosamine under th ...


97
Raymond A Firestone, Peter L Barker: Substituted azetidinones as anti-inflammatory and antidegenerative agents. Merck & Co, Theresa Y Cheng, Michael C Sudol, July 14, 1987: US04680391 (63 worldwide citation)

New substituted azetidinones are found to be potent elastase inhibitors and thereby useful anti-inflammatory/antidegenerative agents.


98
Abraham Sunshine, Eugene M Laska, Carole E Siegel: Analgesic and anti-inflammatory compositions comprising diphenhydramine and methods of using same. Richardson Vicks, Burns Doane Swecker & Mathis, January 15, 1991: US04985459 (62 worldwide citation)

Novel pharmaceutical compositions of matter are provided comprising analgesic/non-steroidal anti-inflammatory drugs and diphenhydramine and methods of using said compositions to elicit an enhanced analgesic and/or anti-inflammatory response in mammalian organisms in need of such treatment.


99
Kim Hyung Ook, Ryu Je Ho, Jung Jae Yoon, Lee Nam Kyu, Kim Joo Hyon, Kim Eun Jeong, Joen Sun Duck, Kim Ji Hong, Rhee Hae In, Cho Yong Baik, Kwak Wie Jong, Kim Sun Ho, Kim Seon Mi, Noh Eun Jung: Pyridine derivatives, methods of their preparations, and pharmaceutical compositions containing the same. Sk Chemicals, Kim Hyung Ook, Ryu Je Ho, Jung Jae Yoon, Lee Nam Kyu, Kim Joo Hyon, Kim Eun Jeong, Joen Sun Duck, Kim Ji Hong, Rhee Hae, Cho Yong Baik, Kwak Wie Jong, Kim Sun Ho, Kim Seon Mi, Noh Eun Jung, PAIK Nam Hoon, October 26, 2006: WO/2006/112666 (62 worldwide citation)

The present invention relates to pyridine derivatives having inhibitory effects on synthesis of cytokines, which are involved in inflammatory reactions, thus being useful as a therapeutic agent for treatment of inflammation-related diseases, immune-related diseases and chronic inflammatory diseases ...


100
Cortney E Henderson, Taylor W Aronhalt, Chunlin Yang, Charles J Scheib, Venkataramanan Mandakolathur Vasudevan, Mark D Timmer, Richard W Timm, Tamara Widenhouse, Steven G Hall: Layered tissue thickness compensator. Ethicon Endo Surgery, May 10, 2016: US09332974 (61 worldwide citation)

A tissue thickness compensator may generally comprise a first layer comprising a first medicament, a second layer comprising a second medicament, and a third layer comprising a third medicament. The tissue thickness compensator may comprise a first layer comprising a first medicament, a second layer ...