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James Doherty
Dorn Conrad P, Finke Paul E, Maccoss Malcolm, Doherty James B, Shah Shrenik K, Hagmann William K: New substituted azetidinones as anti-inflammatory and antidegenerative agents.. Merck & Co, April 22, 1992: EP0481671-A1 (40 worldwide citation)

New substituted azetidinones of the general formula (A') which have been found to be potent elastase inhibitors and thereby useful anti-inflammatory and antidegenerative agents are described. e


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James E Brown, Wouter E Roorda: Directional drug delivery stent and method of use. Alza Corporation, Burns Doane Swecker & Mathis L, June 6, 2000: US06071305 (462 worldwide citation)

The invention relates to a directional drug delivery stent which includes an elongated or tubular member having a cavity containing a biologically active agent. In one embodiment, the active agent is diffused from the reservoir directly to the walls of a body lumen, such as a blood vessel, through d ...


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David J Vachon: Anti-inflammatory biosensor for reduced biofouling and enhanced sensor performance. Medtronic MiniMed, Gates & Cooper, December 26, 2006: US07153265 (265 worldwide citation)

A biosensor including an external surface, and an accessory material in close proximity to the external surface. The accessory material includes a coating containing a hydrophilic material and/or a fiber modified to deliver a therapeutic agent. The biosensor modifies a biological response to the bio ...


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Robert E Fischell, David R Fischell, Adrian R M Upton, Dennis R Potts, Benjamin D Pless: Means and method for the intracranial placement of a neurostimulator. NeuroPace, July 30, 2002: US06427086 (258 worldwide citation)

Disclosed is a means and method for placing an implantable neurostimulator control module into a place in the cranium where cranial bone has been removed. The method for accomplishing this cranial implantation is by first removing a patient's hair over the site of the implant, then cutting the ...


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Thomas R Tice, Danny H Lewis, Donald R Cowsar, Lee R Beck: Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents. The Stolle Research and Development Corporation, Southern Research Institute, Oblon Fisher Spivak McClelland & Maier, July 23, 1985: US04530840 (251 worldwide citation)

An anti-inflammatory agent containing microparticle composition prepared by a process, comprising (a) dissolving or dispersing an anti-inflammatory agent in a solvent and dissolving a biocompatible and biodegradable wall forming material in said solvent; (b) dispersing said solvent containing said a ...


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Abraham J Domb, Alain Shikani, Andrew S T Haffer, Manoj Maniar: Anti-infective and anti-inflammatory releasing systems for medical devices. Leonard Bloom, Leonard Bloom, April 30, 1996: US05512055 (250 worldwide citation)

Devices are provided having a polymer coating incorporating compounds inhibiting inflammation and infection, along with subsequent tissue growth onto and around the device. Preferred embodiments include catheters, tubes, and implants that abut tissue following implantation into the body, especially ...


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Francis Moussy, Donald Kreutzer, Diane Burgess, Jeffrey Koberstein, Fotios Papadimitrakopoulos, Samuel Huang: Implant coating for control of tissue/implant interactions. The University of Connecticut, Cantor Colburn, December 24, 2002: US06497729 (236 worldwide citation)

A tissue/implant interface, comprising an implant and a bioactive polymer layer adjacent at least a portion of the outer surface of the implant, wherein the polymer layer contains at least one tissue response modifier covalently attached to the polymer layer or entrapped within the polymer layer in ...


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Martin James MacPhee, William Nash Drohan, Carlos I Lasa Jr, Gene Liau, Christian Haudenschild: Supplemented and unsupplemented tissue sealants, methods of their production and use. The American National Red Cross, Sterne Kessler Goldstein & Fox P L L C, March 6, 2001: US06197325 (226 worldwide citation)

This invention provides methods for the localized delivery of supplemented tissue sealants, wherein the supplemented tissue sealants comprise at least one composition which is selected from one or more antibodies, analgesics, anticoagulants, anti-inflammatory compounds, antimicrobial compositions, a ...



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