1
William E Kreighbaum, William T Comer: Anti-tumor quinazoline compounds. Mead Johnson & Company, Robert H Uloth, Robert E Carnahan, August 10, 1982: US04343940 (60 worldwide citation)

4-Ethyl-6-methoxy-7-(oxiranylmethoxy)quinazoline and its isomer 4-ethyl-7-methoxy-6-(oxiranylmethoxy)quinazoline have potent anti-tumor activity in animals.


2
Kreighbaum William E, Comer William T: Anti-tumor quinazoline compounds. Bristol Myers Co, September 10, 1982: FR2501207-A1

6 and/or 7-(oxiranylmethoxy)- quinazolines of the formula:- wherein one of R and R is oxiranylmethyl and the other is methyl or oxiranylmethyl and R and R are hydrogen atoms or various substituents, have potent anti-tumor activity in animals.


3
Kreighbaum William E, Comer William T: Composes de quinazoline anti-tumoraux, Anti-tumor quinazoline compounds. Bristol Myers Squibb Company, GOWLING LAFLEUR HENDERSON, CA1163995

MJ 411C ANTI-TUMOR QUINAZOLINE COMPOUNDS Abstract of the Disclosure 4-Ethyl-6-methoxy-7-(oxiranylmethoxy)quinazoline and its isomer 4-ethyl-7-methoxy-6-(oxiranylmethoxy)quinazoline have potent anti-tumor activity in animals.


4
Anti-tumor quinazoline compounds. Bristol Myers Co, September 15, 1982: GB2094295-A

6 and/or 7-(oxiranylmethoxy)- quinazolines of the formula:- wherein one of R and R is oxiranylmethyl and the other is methyl or oxiranylmethyl and R and R are hydrogen atoms or various substituents, have potent anti-tumor activity in animals.


5
Craybaum William E, Komer William T: Process for the preparation of anti-tumor quinazoline compounds. Bristol Myers Co, September 22, 1988: KR1019820000576

Quinazoline compds. of formula (I) are prepd. by reacting compd. of formula (II) with epichlorohydrin or epibromohydrin in the presence of a base, e.g. NaOH, KOH, alkoxide and carbonate. In the formulas, one of R6 and R7 is oxiranylmethyl and the other is methyl or oxiranylphenyl; R2 and R4 are each ...