1
Joseph F Foss, Michael F Roizen, Jonathan Moss, Chun Su Yuan, William Drell: Use of methylnaltrexone and related compounds. Arch Development Corporation, UR Labs, Christie Parker & Hale, October 26, 1999: US05972954 (117 worldwide citation)

A method for preventing or treating opioid induced side effects including dysphoria, pruritus and urinary retention and non-opioid induced changes in gastrointestinal motility. The method comprises administering methylnaltrexone or another quaternary derivative of noroxymorphone to a patient prior t ...


2
Leon I Goldberg: Quaternary derivatives of noroxymorphone which relieve nausea and emesis. University of Chicago, Christie Parker & Hale, January 12, 1988: US04719215 (104 worldwide citation)

Quaternary derivatives of noroxymorphone are used to prevent or relieve nausea and emesis associated with the use of narcotic analgesics without interfering with the analgesic activity of the drugs. A particularly preferred compound is methylnaltrexone. The compound is administered in a concentratio ...


3
Leon I Goldberg: Method for reducing emesis and nausea induced by the administration of an emesis causing agent. Arch Development Corporation, Christie Parker & Hale, April 7, 1992: US05102887 (101 worldwide citation)

A method for preventing or relieving nausea and emesis associated with the use of an emesis-causing agent in warm-blooded animals comprises administering to the animal both a narcotic analgesic and a quaternary derivative of noroxymorphone prior to, simultaneously with of after administering the eme ...


4
Leon I Goldberg: Quaternary derivatives of noroxymorphone which relieve nausea and emesis. The University of Chicago, Christie Parker & Hale, August 29, 1989: US04861781 (99 worldwide citation)

Quaternary derivatives of noroxymorphone are used to prevent or relieve nausea and emesis associated with the use of narcotic analgesics without interfering with the analgesic activity of the drugs. A particularly preferred compound is methylnaltrexone. The compound is administered in a concentratio ...


5
Kersten Walter, Thomas Profitlich: Galenic composition containing opioid antagonists. Klinge Pharma, Heller Ehrman White & McAuliffe, July 16, 2002: US06419959 (62 worldwide citation)

A pharmaceutical composition for oral administration contains naloxone-, N-methylnaloxone- and/or N-methylnaltrexone-containing particles which release the active substance depending on the ambient pH. This ensures the liberation of the active substance over the whole gastrointestinal tract. The sid ...


6
Sanghvi Suketu P, Boyd Thomas A: Pharmaceutical formulations containing methylnaltrexone. Progenics Pharmaceuticals, Sanghvi Suketu P, Boyd Thomas A, GATES Edward R, October 28, 2004: WO/2004/091623 (53 worldwide citation)

Stable pharmaceutical compositions useful for administering methylnaltrexone are described, as are methods for making the same. Kits, including these pharmaceutical compositions, also are provided.


7
Joseph F Foss, Michael F Roizen, Jonathan Moss, Chun Su Yuan, William Drell: Use of methylnaltrexone and related compounds. Christie Parker & Hale, August 14, 2001: US06274591 (49 worldwide citation)

A method for preventing or treating the opioid induced side effect, inhibition of gastrointestinal motility is disclosed. The method comprises administering methylnaltrexone or another quaternary derivative of noroxymorphone to a patient prior to the administration of an opioid or after the onset of ...


8
Doshan Harold D, Perez Julio: (r)-n-methylnaltrexone, processes for its synthesis and its pharmaceutical use. Progenics Pharmaceuticals, Doshan Harold D, Perez Julio, VAN AMSTERDAM John R, November 30, 2006: WO/2006/127899 (44 worldwide citation)

This invention relates to stereoselective synthesis of R-MNTX and intermediates thereof, pharmaceutical preparations comprising R-MNTX or intermediates thereof and methods for their use.


9
Joseph F Foss, Michael F Roizen, Jonathan Moss, Chun Su Yuan, William Drell: Use of methylnaltrexone and related compounds. The University of Chicago, U R Labs, Wolf Greenfield & Sacks P C, August 19, 2003: US06608075 (43 worldwide citation)

A method for preventing or treating opioid induced changes in gastrointestinal motility. The method comprises administering methylnaltrexone or another quaternary derivative of noroxymorphone to a patient prior to the administration of an opioid or after the onset of side effects induced by the admi ...


10
Joseph F Foss, Michael F Roizen, Jonathan Moss, Chun Su Yuan, William Drell: Use of methylnaltrexone and related compounds to treat chronic opioid use side affects. UR Labs, The University of Chicago, Wolf Greenfield & Sacks P C, May 6, 2003: US06559158 (30 worldwide citation)

A method of preventing or treating an opioid-induced side effect in a patient who has been chronically taking opioids, the method comprising administering a quaternary derivative of noroxymorphone in an amount sufficient to prevent or treat the side effect in the patient, but which amount would be i ...