1
Tarran Jones
Britta Hardy, Steven Tarran Jones, Leah Klapper: Humanized immunomodulatory monoclonal antibodies for the treatment of neoplastic disease or immunodeficiency. CureTech, Mor Research Applications, Winston & Strawn, February 19, 2008: US07332582 (21 worldwide citation)

The present invention provides to a humanized monoclonal antibody having immunostimulatory effects. This antibody binds specifically to B lymphoblastoid cells, induces proliferation and activation of peripheral blood lymphocytes, and is capable of eliciting an anti-tumor effect upon administration t ...


2
Tarran Jones
Britta Hardy, Steven Tarran Jones, Leah Klapper: Humanized immunomodulatory monoclonal antibodies for the treatment of immunodeficiency. CureTech, Mor Research Applications, Winston & Strawn, July 19, 2011: US07981416 (9 worldwide citation)

The present invention provides to a humanized monoclonal antibody having immunostimulatory effects. This antibody binds specifically to B lymphoblastoid cells, induces proliferation and activation of peripheral blood lymphocytes, particularly T cells, and is capable of eliciting an anti-tumor effect ...


3
Tarran Jones
Britta Hardy, Steven Tarran Jones, Leah Klapper: Human immunomodulatory monoclonal antibodies for the treatment of cancer. CureTech, Mor Research Application, Winston & Strawn, April 28, 2009: US07524498 (7 worldwide citation)

The present invention provides to a humanized monoclonal antibody having immunostimulatory effects. This antibody binds specifically to B lymphoblastoid cells, induces proliferation and activation of peripheral blood lymphocytes, particularly T cells, and is capable of eliciting an anti-tumor effect ...


4
Randy R Robinson, Alvin Y Liu, Jeffrey A Ledbetter: Chimeric antibody with specificity to human B cell surface antigen. XOMA Corporation, Sterne Kessler Goldstein & Fox, March 19, 1996: US05500362 (339 worldwide citation)

The present invention relates to a chimeric IgG1 antibody molecule comprising two heavy chains and two light chains, each of the chains comprising a human constant region and a variable region, said antibody having specificity for the antigen bound by the 2H7 murine monoclonal antibody. The inventio ...


5
Leon W M M Terstappen, Galla Chandra Rao, Jonathan W Uhr, Emilian V Racila, Paul A Liberti: Methods and reagents for the rapid and efficient isolation of circulating cancer cells. Immunivest Corporation, Board of Regents The University of Texas System, Dann Dorfman Herrell and Skillman, April 2, 2002: US06365362 (162 worldwide citation)

A highly sensitive assay is disclosed which combines immunomagnetic enrichment with multiparameter flow cytometric and immunocytochemical analysis to detect, enumerate and characterize carcinoma cells in the blood. The assay can detect one epithelial cell or less in 1 ml of blood and has a greater s ...


6
Marc D Better, Arnold H Horwitz, Randy R Robinson, Shau Ping Lei, Changtung P Chang: Production of chimeric mouse-human antibodies with specificity to human tumor antigens. Xoma Corporation, Sterne Kessler Goldstein & Fox P L L C, November 19, 1996: US05576184 (133 worldwide citation)

Gene expression elements and their use in production of chimeric antibodies with human constant regions and murine variable regions, and mouse human chimeric antibodies having specificity to human tumor cells, methods of their production, and their use.


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Hans Hansen, Zhengxing Qu, David M Goldenberg: Anti-CD20 antibodies and fusion proteins thereof and methods of use. Immunomedics, Rossi Kimms & McDowell, December 19, 2006: US07151164 (106 worldwide citation)

The present invention provides humanized, chimeric and human anti-CD20 antibodies and CD 20 antibody fusion proteins that bind to a human B cell marker, referred to as CD20, which is useful for the treatment and diagnosis of B-cell disorders, such as B-cell malignancies and autoimmune diseases, and ...


9
Leon W M M Terstappen, Galla Chandra Rao, Jonathan W Uhr, Emilian V Racila, Paul A Liberti: Methods and reagents for the rapid and efficient isolation of circulating cancer cells. Immunivest Corporation, Dann Dorfman Herrell and Skillman, November 11, 2003: US06645731 (106 worldwide citation)

A highly sensitive assay is disclosed which combines immunomagnetic enrichment with multiparameter flow cytometric and immunocytochemical analysis to detect, enumerate and characterize carcinoma cells in the blood. The assay can detect one epithelial cell or less in 1 ml of blood and has a greater s ...


10
Dirk C Soenksen, George McNamara, Yuval Garini, Nir Katzir: Method of cancer cell detection. Applied Spectral Imaging, Mark M Friedman, November 30, 1999: US05995645 (104 worldwide citation)

A method for cancer cell detection including the steps of (a) staining an analyzed sample with at least first and second dyes, the dyes being selected such that the first dye better adheres to normal cells whereas the second dye better adheres to cancer cells; (b) spectrally imaging the sample throu ...