1
Jannis G Stavrianopoulos, Dollie Kirtikar, Kenneth H Johnston, Barbara E Thalenfeld: Method and structures employing chemically-labelled polynucleotide probes. Enzo Biochem, Serle I Mosoff, Elaine P Brenner, Helen Tzagoloff, February 19, 1991: US04994373 (300 worldwide citation)

Polynucleotide sequences in a sample of biological or nonbiological material are detected by a method involving fixing of the sequences on a solid support and forming an entity between the fixed sequences and chemically-labeled polynucleotide or oligonucleotide probes having a sequence complementary ...


2
R Terry Dunlay, D Lansing Taylor: System for cell-based screening. Cellomics, David S McDonnell Boehnen Hulbert & Berghoff Harper, November 23, 1999: US05989835 (222 worldwide citation)

The invention relates to an optical system for determining the distribution, environment, or activity of fluorescently labeled reporter molecules in cells for the purpose of screening large numbers of compounds for specific biological activity. The invention involves providing cells containing fluor ...


3
Mark S Wang, Limin Li: Rapid screening assay methods and devices. Functional Genetics, Bertram I Rae Venter Law Group P C Rowland, July 13, 1999: US05922617 (206 worldwide citation)

Methods and apparatus are employed for determining interactions between different components, of the same or different type of composition. The apparatus provides for arrays of samples in tracks, where light emitting labels are excited and emitted light detected. Headers are provided for defining si ...


4
Heller Michael J, Jablonski Edward J: Fluorescent stokes shift probes for polynucleotide hybridization assays.. Molecular Biosystems, July 29, 1987: EP0229943-A2 (197 worldwide citation)

Fluorescent stokes shift probes for polynucleotide hybridization assays are designed to provide predetermined nucleotide base unit spacings between the donor and acceptor fluorophores. When the probes are hybridized to the target polynucleotide the fluorophores paired for non-radiative energy transf ...


5
Lyle J Arnold Jr, Norman C Nelson: Homogenous protection assay. Gen Probe Incorporated, Lyon & Lyon, February 1, 1994: US05283174 (174 worldwide citation)

Improved homogenous diagnostic assay methods and labels for detecting an analyte in a medium when the analyte is a member of a specific binding pair. The methods and labels provide procedures for reducing background and increasing sensitivity. The binding partner of the analyte is labeled with a sub ...


6
Fei Mao, Wai Yee Leung, Richard P Haugland: Sulfonated xanthene derivatives. Molecular Probes, Anton E Skaugset, October 10, 2000: US06130101 (170 worldwide citation)

The present invention describes xanthene dyes, including rhodamines, rhodols and fluoresceins that are substituted one or more times by a sulfonic acid or a salt of a sulfonic acid. The dyes of the invention, including chemically reactive dyes and dye-conjugates are useful as fluorescent probes, par ...


7
William L Reber, Cary D Perttunen, Christopher K Y Chun: Binding assay methods. Motorola, August 10, 1999: US05935785 (158 worldwide citation)

In accordance with a first aspect, a binding assay comprises a machine-readable storage medium which supports a molecular receptor (22). In accordance with a second aspect, a support member (50) supports first (22) and second (24) molecular receptors and first (26) and second (28) data identifying t ...


8
Axel Durkop, Otto Wolfbeis: Bioanalytical measuring method using oxidases and lanthanoid-ligand complexes. Active Motif Chromeon, Rothwell Figg Ernst & Manbeck, May 30, 2006: US07052864 (144 worldwide citation)

The present invention concerns biological methods of determination using enzymes from the group of oxidases and using optical indicators from the group of lanthanoid-ligand complexes.


9
Hee Chol Kang: Conjugates of sulforhodamine fluorophores with enhanced fluorescence. Molecular Probes, Allegra J Helfenstein, Anton E Skaugset, December 8, 1998: US05846737 (140 worldwide citation)

The invention describes useful conjugates of sulforhodamine, wherein the conjugated substance and the fluorophore are separated by an alkanoic acid spacer that is attached to the fluorophore via a sulfonamide bond. The increased length of the covalent linkage due to the spacer results in dye-conjuga ...


10
Joseph R Lakowicz, Badri P Maliwal, Richard Thompson, Alvydas Ozinskas: Fluorescent energy transfer immunoassay. Joseph R Lakowicz, Richard Thompson, Rothwell Figg Ernst & Kurz, May 20, 1997: US05631169 (133 worldwide citation)

A fluorometric luminescence immunoassay method includes forming a sample by exposing a first immune reaction reactant to a second immune reaction reactant capable of reacting with the first reactant, one of the first and second immune reaction reactants being labelled with a photoluminescent energy ...