21
Stephen J Brown: System and method for preventing, diagnosing, and treating genetic and pathogen-caused disease. Health Hero Network, Lumen Intellectual Property Services, November 16, 1999: US05985559 (227 worldwide citation)

Genetic testing allows an individual to determine whether or not he or she has a predisposition to a certain disease. The degree of expressivity of a certain disease will be determined in part by an individual's environment and lifestyle. The present invention interprets a patient's gene sequence an ...


22
H Garrett Wada, Anne R Kopf Sill, Marja Liisa Alajoki, J Wallace Parce, Benjamin N Wang, Andrea W Chow, Robert S Dubrow, Yevgeny Yurkovetsky, Javier Anibal Farinas: Focusing of microparticles in microfluidic systems. Caliper Technologies, Andrew L Filler, Quine Intellectual Property Law Group, July 15, 2003: US06592821 (224 worldwide citation)

Methods and systems for particle focusing to increase assay throughput and sensitivity in microscale systems are provided. The invention includes methods for providing substantially uniform flow velocity to flowing particles in microfluidic devices. Methods of sorting members of particle populations ...


23
Paul M Lizardi, Fred R Kramer, Sanjay Tyagi, Cesar E Guerra, Hilda M L Buyoli: Nucleic acid process containing improved molecular switch. The Public Health Research Institute, The Salk Instiute for Biological Studies, Davis Hoxie Faithfull and Hapgood, June 2, 1992: US05118801 (223 worldwide citation)

A probe for the detection of a nucleic acid target sequence containing a molecular switch comprising three essential elements: a probe sequence of 20-60 nucleotides surrounded by switch sequences of 10-40 nucleotides which are complementary to each other, wherein the state of the switch is useful fo ...


24
Steven C Charlton, Larry D Johnson, Matthew K Musho, Joseph E Perry: Method and apparatus for calibrating a sensor element. Bayer Corporation, Jerome L Jeffers, January 5, 1999: US05856195 (220 worldwide citation)

A method and apparatus are provided for calibrating a sensor for determination of analyte concentration. The meter includes a sensor for receiving a user sample to be measured and a processor for performing a predefined test sequence for measuring a predefined parameter value. A memory can be couple ...


25
Ballivet Marc, Kauffman Stuart Alan: Method for obtaining dna, rna, peptides, polypeptides or proteins by means of a dna recombinant technique. Ballivet Marc, Kauffman Stuart Alan, June 10, 1987: GB2183661-A (219 worldwide citation)

Genes at least partially composed of stochastic synthetic polynucleotides are simultaneously produced wihtin the same medium, the genes thus obtained are introduced into host cells; the independent strains of modified host cells enclosing said genes are simultaneously grown, so as to clone the stoch ...


26
Christopher T Maus, Craig A Coad, Jackson B Connolly, Noah M Coad, James L Moody, Kenn A Nesbitt, Kenneth D Clegg: Health monitoring and diagnostic device and network-based health assessment and medical records maintenance system. Lifestream Technologies, Michael J Mehrman, Mehrman Law Office PC, August 5, 2003: US06602469 (214 worldwide citation)

A health monitoring and diagnostic device (LIFESTREAM cholesterol meter) configured as a self-contained testing and diagnostic unit in a clam-shell type case. One side of the case includes a spring-loaded finger stick and a compartment for carrying one or more packages of disposable items including ...


27
Koon wah Leong, Yeung Siu Yu, Edward Gray Rice: Multi-layer reagent test strip. Lifescan, April 29, 2003: US06555061 (214 worldwide citation)

A reagent test strip for measuring an analyte concentration in a biological fluid has a spreading mesh sandwiched between a support and a reagent matrix. The support has a through hole that is covered by the mesh. In use, a sample of the fluid is applied through the hole in the support to the spread ...


28
Michael P Nova, Zahra Parandoosh, Andrew E Senyei, Xiao Yi Xiao, Gary S David, Yozo Satoda, Chanfeng Zhao, Hanan Potash: Matrices with memories and uses thereof. Irori, Brown Martin Haller & McClain, October 5, 1999: US05961923 (214 worldwide citation)

Combinations, called matrices with memories, of matrix materials that are encoded with an optically readable code are provided. The matrix materials are those that are used in as supports in solid phase chemical and biochemical syntheses, immunoassays and hybridization reactions. The matrix material ...


29
James L Hartley: Amplification of nucleic acid sequences using oligonucleotides of random sequence as primers. Life Technologies Incorporated, Sterne Kessler Goldstein & Fox, August 27, 1991: US05043272 (214 worldwide citation)

According to this invention, a process for substantially amplifying template nucleic acid present in a sample is described, wherein said amplification may be performed without prior knowledge of specific sequences, which process comprises apposition of random oligonucleotide primers to said template ...


30
Robert Thomas Hudak, Lorraine Bautista: Line test device and methods of use. Acon Laboratories, David Preston, David R Preston & Associates APC, May 20, 2003: US06565808 (213 worldwide citation)

The present invention recognizes that it can be desirable to have a sample receiving chamber integral to or engageable with a test platform, such as a test platform that includes a test strip. The sample receiving chamber is preferably separate or separable from the test platform, but that need not ...