1
Tarran Jones
Tsuchiya Masayuki, Sato Koh, Bendig Mary Margaret, Jones Steven Tarran, Saldanha Jose William: Reconstituted human antibody against human interleukin 6 receptor.. Chugai Pharmaceutical, December 14, 1994: EP0628639-A1 (53 worldwide citation)

A reconstituted human antibody against a human interleukin 6 receptor (IL-6R), which is composed of: (A) an L chain composed of (1) the C region of a human L chain and (2) the V region of an L chain comprising the framework region (FR) of a human L chain and the complementarity-determining region (C ...


2
Hsiang-Wen Tseng
LAI HUI MIN, KUO ZONG KENG, CHIANG WEN SHENG, TSENG HSIANG WEN: [ZH] 含CD54表达之报告系统之免疫细胞的应用以及经克隆之新颖细胞, [EN] Application of immune cell including CD54 expression reporting system and cloned novel cell. Industrial Technology Research Institute, zhang wenhui, June 24, 2015: CN142929968

[EN] The present invention provides a method of confirming an immunoregulation substance, comprising: (a) providing a to-be-measured substance and an immune cell, wherein the immune cell includes a CD54 expression reporting system, and the CD54 expression reporting system comprises a CD54 gene promo ...


3
Richard Axel, Michael H Wigler, Saul J Silverstein: Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials. The Trustees of Columbia University in the City of New York, John P White, January 6, 1987: US04634665 (313 worldwide citation)

The present invention relates to processes for inserting DNA into eucaryotic cells, particularly DNA which includes a gene or genes coding for desired proteinaceous materials for which no selective criteria exist. The insertion of such DNA molecules is accomplished by cotransforming eucaryotic cells ...


4
Boss Michael Alan, Kenten John Henry, Emtage John Spencer, Wood Clive Ross: Processes for the production of multichain polypeptides or proteins.. Celltech, October 3, 1984: EP0120694-A2 (274 worldwide citation)

This invention relates to multichain polypeptides or proteins and processes for their production in cells of host organisms which have been transformed by recombinant DNA techniques. According to a first aspect of the present invention, there is provided a process for producing a heterologous multic ...


5
William L Cleveland, Bernard F Erlanger: Protein-free culture medium. Columbia University in the City of New York, Oblon Fisher Spivak McClelland & Maier, August 30, 1988: US04767704 (234 worldwide citation)

A trace element mixture suitable for use in a protein-free tissue culture medium, which comprises water-soluble compounds selected from acids, bases, and salts containing copper, iron, zinc, manganese, silicon, molybdenum, vanadium, nickel, tin, aluminum, silver, barium, bromine, cadmium, cobalt, ch ...


6
Sudhir Kumar: Serum-free, synthetic, completely chemically defined tissue culture media. April 14, 1987: US04657866 (205 worldwide citation)

A serum-free, synthetic tissue culture media is described which is completely defined chemically. The two media described can be used for growing all types of human or animal cell lines in tissue culture without addition of any protein, amino acids, hormones, sources of energy, salts, vitamins, etc. ...


7
Bott Richard Ray, Ferrari Eugenio, Wells James Allen, Estell David Aaron, Henner Dennis James: Procaryotic carbonyl hydrolases, methods, dna, vectors and transformed hosts for producing them, and detergent compositions containing them.. Genentech, January 9, 1985: EP0130756-A1 (186 worldwide citation)

Methods and vectors are provided for the production of procaryotic carbonyl hydrolases in recombinant systems. DNA which encodes such hydrolases are mutated at predetermined regions by known methods or by a novel point mutagenesis method in order to generate mutant hydrolases. Particular point mutat ...


8
Enzo Paoletti, Dennis Panicali: Modified vaccinia virus and methods for making and using the same. Health Research Incorporated, Curtis Morris & Safford, September 6, 1988: US04769330 (183 worldwide citation)

What are disclosed are methods for modifying the genome of vaccinia virus to produce vaccinia mutants, particularly by the introduction into the vaccinia genome of exogenous DNA; modified vaccinia prepared by such methods; certain DNA sequences and unmodified and genetically modified microorganisms ...


9
Nakagawa Satochi, Mizoguchi Hiroshi, Ando Seiko, Hayashi Mikiro, Ochiai Keiko, Yokoi Haruhiko, Tateishi Naoko, Senoh Akihiro, Ikeda Masato, Ozaki Akio: Novel polynucleotides. Kyowa Hakko Kogyo, June 20, 2001: EP1108790-A2 (180 worldwide citation)

Novel polynucleotides derived from microorganisms belonging to coryneform bacteria and fragments thereof, polypeptides encoded by the polynucleotides and fragments thereof, polynucleotide arrays comprising the polynucleotides and fragments thereof, recording media in which the nucleotide sequences o ...


10
Howard M Temin, Shinichi Watanabe: Helper cell. Wisconsin Alumni Research Foundation, Quarles & Brady, March 17, 1987: US04650764 (175 worldwide citation)

A helper cell for providing retrovirus protein which is required by a normally replication incompetent recombinant retrovirus gene sequence in order to replicate is disclosed. In one embodiment there is a eukaryotic host cell, a first retrovirus gene sequence in the cell which has a helper portion c ...