1
David Mosley
Peter A Carr, Brian Y Chow, Joseph M Jacobson, David W Mosley, Christopher Emig: Methods for high fidelity production of long nucleic acid molecules. Foley & Lardner, November 17, 2005: US20050255477-A1

This invention generally relates to nucleic acid synthesis, in particular DNA synthesis. More particularly, the invention relates to the production of long nucleic acid molecules with precise user control over sequence content. This invention also relates to the prevention and/or removal of errors w ...


2
David Mosley
Peter A Carr, Brian Y Chow, Joseph M Jacobson, David W Mosley, Christopher Emig: Methods for high fidelity production of long nucleic acid molecules with error control. Foley & Lardner, October 13, 2005: US20050227235-A1

This invention generally relates to nucleic acid synthesis, in particular DNA synthesis. More particularly, the invention relates to the production of long nucleic acid molecules with precise user control over sequence content. This invention also relates to the prevention and/or removal of errors w ...


3
Higgins Irving John, Mccann James Michael, Davis Graham, Hill Hugh Allen Oliver, Zwanziger Ron, Treidl Bernhard Ludwig, Birket Nigel Norman, Plotkin Elliot Verne: Sensor electrode systems.. Genetics Int, December 12, 1984: EP0127958-A2 (828 worldwide citation)

This specification discloses sensor electrodes, and their combination with reference electrodes; the manufacture of such electrodes; apparatus utilising such electrodes; and electrical circuitry into which such electrodes can be incorporated, specifically the establishment of certain design criteria ...


4
Padlan Eduardo A, Mark George E Iii, Daugherty Bruce L: A method for reducing the immunogenicity of antibody variable domains.. Merck & Co, Nat Inst Health, December 23, 1992: EP0519596-A1 (410 worldwide citation)

A unique method is disclosed for identifying and replacing immunoglobulin surface amino acid residues which converts the antigenicity of a first mammalian species to that of a second mammalian species. The method will simultaneously change immunogenicity and strictly preserve ligand binding properti ...


5
Backman Keith C, Wang Chang Ning J: Method for detecting a target nucleic acid sequence.. Bioteknika International, June 14, 1989: EP0320308-A2 (389 worldwide citation)

Target nucleic acid is detected by reorganizing an excess of two complementary pairs of single stranded probes, which hybridize to contiguous target sequences. Nucleic acid in the sample is annealed to the probes, and contiguous sequences are ligated to form complementary detectable fused probes com ...


6
Winter Gregory Paul, Gussow Detlef, Ward Elizabeth Sally: Cloning immunoglobulin variable domain sequences.. Medical Res Council, May 16, 1990: EP0368684-A1 (325 worldwide citation)

The present invention relates to single domain ligands derived from molecules in the immunoglobulin (Ig) superfamily, receptors comprising at least one such ligand, methods for cloning, amplifying and expressing DNA sequences encoding such ligands, preferably using the polymerase chain reaction, met ...


7
Alexandrov Nickolai, Brover Vyacheslav, Chen Xianfeng, Subramanian Gopalakrishnan, Troukhan Maxim E, Zheng Liansheng, Dumas J: Sequence-determined dna fragments and corresponding polypeptides encoded thereby. Ceres, September 6, 2000: EP1033405-A2 (304 worldwide citation)

The present invention provides DNA molecules that constitute fragments of the genome of a plant, and polypeptides encoded thereby. The DNA molecules are useful for specifying a gene product in cells, either as a promoter or as a protein coding sequence or as an UTR or as a 3' termination sequence, a ...


8
Drmanac Radoje T, Crkvenjakov Radomir B: Process for determination of a complete or a partial contents of very short sequences in the samples of nucleic acids connected to the discrete particles of microscopic size by hybridization with oligonucleotide probes.. Ro Inst Za Molekularnu Genetik, October 17, 1990: EP0392546-A2 (261 worldwide citation)

Determination of the formula of genomic DNA, i.e. genome sequencing, by a hybridization with oligonucleotide probes (YU Patent Application 570/87) envisages the use of 100000 oligonucleotide probes and the same number of hybridizations with 6000000 of addressed sample-clones on filters in order to d ...


9
Erlich Henry Anthony, Saiki Randall Keichi, Horn Glenn Thomas, Mullis Kary Banks: Process for detecting specific nucleotide variations and genetic polymorphisms present in nucleic acids and kits therefor.. Cetus, September 16, 1987: EP0237362-A1 (261 worldwide citation)

A process for detecting the presence or absence of at least one nucleotide variation in sequence in one or more nucleic acids in a sample comprises: (a) treating the sample, together or sequentially with 4 different nucleotide triphosphates (I), an agent (II) for polymerisation of (I), and one oligo ...


10
Davey Cheryl, Malek Lawrence T: Nucleic acid amplification process.. Cangene, August 30, 1989: EP0329822-A2 (253 worldwide citation)

This invention relates to a process for amplifying a specific nucleic acid sequence. The process involves synthesizing single-stranded RNA, single-stranded DNA and double-stranded DNA. The single-stranded RNA is a first template for a first primer, the single-stranded DNA is a second template for a ...