Winter Gregory Paul: Recombinant antibodies and methods for their production.. Winter Gregory Paul, September 30, 1987: EP0239400-A2 (902 worldwide citation)

An altered antibody is produced by replacing the complementarity determining regions (CDRs) of a variable region of an immunoglobulin (Ig) with the CDRs from an Ig of different specificity using recombinant DNA techniques. The gene coding sequences for producing the altered antibody may be produced ...

Daniel J Capon, Laurence A Lasky: Hybrid immunoglobulins. Genentech, Ginger R Dreger, Carolyn R Adler, May 26, 1992: US05116964 (529 worldwide citation)

Immunoglobulin fusion polypeptides are provided, together with methods for making and using them, and nucleic acids encoding them. These polypeptides are useful as cell surface adhesion molecules and ligands, and are useful in therapeutic or diagnostic compositions and methods.

Cabilly Shmuel, Holmes William Evans, Wetzel Ronald Burnell, Heyneker Herbert Louis, Riggs Arthur Dale: Recombinant immunoglobulin preparations, methods for their preparation, dna sequences, expression vectors and recombinant host cells therefor.. Genentech, Hope City, November 14, 1984: EP0125023-A1 (375 worldwide citation)

Recombinant DNA techniques are used to produce both immunoglobulins which are analogous to those normally found in vertebrate systems and to take advantage of these gene modification techniques to construct chimeric or other modified forms.

Winter Gregory Paul, Gussow Detlef, Ward Elizabeth Sally: Cloning immunoglobulin variable domain sequences.. Medical Res Council, May 16, 1990: EP0368684-A1 (319 worldwide citation)

The present invention relates to single domain ligands derived from molecules in the immunoglobulin (Ig) superfamily, receptors comprising at least one such ligand, methods for cloning, amplifying and expressing DNA sequences encoding such ligands, preferably using the polymerase chain reaction, met ...

Ronald A Hitzeman, Franklin E Hagie IV, Benjamin D Hall, Gustav Ammerer: Expression of polypeptides in yeast. Genentech, Washington Research Foundation, Donald R Boys, Christensen O Connor Johnson & Kindness PLLC, August 11, 1998: US05794259 (276 worldwide citation)

A DNA expression vector capable, in a transformant strain of yeast, of expressing a biologically competent polypeptide ordinarily exogenous to yeast under the control of a genetically distinct yeast promoter, the polypeptide not being required for the growth of the transformant; the process of formi ...

Boss Michael Alan, Kenten John Henry, Emtage John Spencer, Wood Clive Ross: Processes for the production of multichain polypeptides or proteins.. Celltech, October 3, 1984: EP0120694-A2 (273 worldwide citation)

This invention relates to multichain polypeptides or proteins and processes for their production in cells of host organisms which have been transformed by recombinant DNA techniques. According to a first aspect of the present invention, there is provided a process for producing a heterologous multic ...

Kunsch Charles A, Choi Gil H, Barash Steven C, Dillon Patrick J, Fannon Michael R, Rosen Craig A: Staphylococcus aureus polynucleotides and sequences. Human Genome Sciences, July 30, 1997: EP0786519-A2 (232 worldwide citation)

The present invention provides polynucleotide sequences of the genome of Staphylococcus aureus, polypeptide sequences encoded by the polynucleotide sequences, corresponding polynucleotides and polypeptides, vectors and hosts comprising the polynucleotides, and assays and other uses thereof. The pres ...

Houghton Michael, Choo Qui Lim, Kuo George: Nanbv diagnostics and vaccines.. Chiron, May 31, 1989: EP0318216-A1 (229 worldwide citation)

A family of cDNA sequences derived from hepatitis C virus (HCV) are provided. These sequences encode antigens which react immunologically with antibodies present in individuals with non-A non-B hepatitis (NANBH), but which generally are absent from individuals infected with hepatitis A virus (HAV) o ...

Greve Henri Marcel Jozef de, Salgado Maria Benita Leonor Fe, Montagu Marc Charles Ernest Va, Vaeck Mark Albert, Zabeau Marcus Florent Oscar, Leemans Jan Jozef August, Hofte Hermanus Fransiscus Paul: Modifying plants by genetic engineering to combat or control insects.. Plant Genetic Systems, September 3, 1986: EP0193259-A1 (223 worldwide citation)

Novel transformation vectors containing novel chimeric genes allow the introduction of exogenous DNA fragments coding for polypeptide toxins produced by Bacillus thuringiensis or having substantial sequence homology to a gene coding for a polypeptide toxin as described herein and expression of the c ...

Sherman M Weissman, Dennis Pereira, Ashwani Sood: Method for cloning genes. Yale University, Millen & White, July 19, 1983: US04394443 (220 worldwide citation)

A method is provided for isolating and identifying a recombinant clone having a DNA segment therein coding for at least one desired heterologous polypeptide, at least a short amino acid sequence of which is known, by effecting cDNA synthesis on a mixture of mRNAs containing the mRNA coding for the d ...