1
Shmuel Cabilly, Herbert L Heyneker, William E Holmes, Arthur D Riggs, Ronald B Wetzel: Recombinant immunoglobin preparations. Genentech, March 28, 1989: US04816567 (2712 worldwide citation)

Altered and native immunoglobulins, including constant-variable region chimeras, are prepared in recombinant cell culture. The immunoglobulins contain variable regions which are immunologically capable of binding predetermined antigens. Methods are provided for refolding directly expressed immunoglo ...


2
Michael A Boss, John H Kenten, John S Emtage, Clive R Wood: Multichain polypeptides or proteins and processes for their production. Celltech, Cushman Darby & Cushman, March 28, 1989: US04816397 (808 worldwide citation)

Multichain polypeptides or proteins and processes for their production in cells of host organisms which have been transformed by recombinant DNA techniques. According to a first aspect of the present invention, there is provided a process for producing a heterologous multichain polypeptide or protei ...


3
Gregory P Winter, Alexander R Duncan, Dennis R Burton: Antibodies with altered effector functions. Scotgen Biopharmaceuticals Incorporated, Spencer & Frank, April 29, 1997: US05624821 (538 worldwide citation)

An antibody with an altered function, e.g. altered affinity for an effector ligand such as Fc receptor (FcR) on a cell or the C1 component of complement is produced by replacing at least one amino acid residue in the constant portion of the antibody with a different residue.


4
Gregory Paul Winter, Alexander Robert Duncan, Dennis Raymond Burton: DNA encoding antibodies with altered effector functions. Scotgen Biopharmaceuticals Incorporated, Spencer & Frank, July 15, 1997: US05648260 (463 worldwide citation)

The DNA encoding an antibody with an altered function, e.g. altered affinity for an effector ligand such as Fc receptor (FcR) on a cell or the Cl component of complement is produced by replacing the nucleic acid encoding at least one amino acid residue in the constant portion of the antibody with nu ...


5
Fu Kuen Lin: DNA sequences encoding erythropoietin. Kiren Amgen, Michael F Borun, Steven M Odre, October 27, 1987: US04703008 (288 worldwide citation)

Disclosed are novel polypeptides possessing part or all of the primary structural conformation and one or more of the biological properties of mammalian erythropoietin ("EPO") which are characterized in preferred forms by being the product of procaryotic or eucaryotic host expression of an exogenous ...


6
James L Grady, Guang Jiong Chen: Bioconversion of waste biomass to useful products. Bioengineering Resources, Howson and Howson, October 13, 1998: US05821111 (247 worldwide citation)

A process is provided for converting waste biomass to useful products by gasifying the biomass to produce synthesis gas and converting the synthesis gas substrate to one or more useful products. The present invention is directed to the conversion of biomass wastes including municipal solid waste, se ...


7
Lawrence S Cousens, Graeme I Bell, Pablo D T Valenzuela: Adenovirus promoter system. Chiron Corporation, Bertram I Rowland, April 9, 1985: US04510245 (207 worldwide citation)

The adenovirus major late promoter is employed as a promoter for expression in a yeast host. Constructions are provided for expression in yeast with the adenovirus major late promoter and a coding segment.


8
Luca Comai: Inhibition resistant 5-enolpyruvyl-3-phosphoshikimate synthetase, production and use. Calgene, Bertram I Rowland, August 13, 1985: US04535060 (196 worldwide citation)

Enhanced resistance to glyphosate, an inhibitor of the aromatic amino acid biosynthesis pathway, is imparted to a glyphosate sensitive host. A mutated aroA gene is employed which expresses 5-enolpyruvyl-3-phosphoshikimate synthetase (EC: 2.5.1.19) (ES-3-P synthetase). Methods are provided for obtain ...


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Herman A DeBoer: Microbial hybrid promoters. Genentech, November 5, 1985: US04551433 (167 worldwide citation)

Novel microbial hybrid promoters and their use to direct the microbial expression of heterologous genes are described. Such promoters are selectively and functionally constructed by recombinant techniques, utilizing the discovery that certain DNA regions of given promoters are responsible for partic ...