51
Ghayur Tariq, Hahn Alfred, Mueller Bernhard: Dual variable domain immunoglobulins and uses thereof. Abbott Laboratories, Ghayur Tariq, Hahn Alfred, Mueller Bernhard, Steel Diana M, December 10, 2009: WO/2009/149185 (31 worldwide citation)

The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.


52
Herold Peter Dr, Buehlmayer Peter Dr: Aza compounds.. Ciba-Geigy, March 6, 1991: EP0415886-A2 (31 worldwide citation)

Azabenzimidazole compounds of the formula in which one or two of the variables Z1, Z2, Z3 and Z4 represent N and the others represent C(R), where R denotes halogen, acyl, optionally esterified or amidated carboxyl or 5-tetrazolyl or R represents -Z-R', in which Z represents a bond or O, S(O)m or NH, ...


53
Goto Giichi, Yukimasa Hidefumi, Imamoto Tetsuji: Cyclic amine compounds and their use.. Takeda Chemical Industries, July 18, 1990: EP0378207-A1 (30 worldwide citation)

A cyclic amine compound of the formula wherein B means a saturated or unsaturated 5- to 7-membered aza-heterocyclic group which may be substituted; A means a bond or an alkylene or alkenylene group which may be substituted by hydrocarbon residues, oxo, hydroxyimino, and/or hydroxy, ___ means either ...


54
Sigal Irving S, Huff Joel R, Darke Paul L: Renin inhibitors useful for the treatment of aids by inhibition of hiv protease.. Merck & Co, March 7, 1990: EP0357332-A2 (30 worldwide citation)

Certain renin inhibitors are useful in the inhibition of HIV protease, the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immun ...


55
Umezawa Hamao, Aoyagi Takaaki, Takeuchi Tomio, Hamada Masa, Naganawa Hiroshi, Muraoka Yasuhiko, Nishikiori Takaaki: Novel, immunosuppressive compounds, a microbiological method for their preparation and their use as medicaments.. Microbial Chem Res Found, September 3, 1986: EP0192828-A2 (30 worldwide citation)

The present invention relates to a new physiologically active substance, Plipastatin, of the following general formula wherein R1 is -C13H27 or -C14H29, R2 is Ala or Val, and the abbreviations Glu, Orn, Tyr, Thr, Pro, Gln, Ile, Ala and Val respectively mean glutaminic acid, ornithine, tyrosine, thre ...


56
Chabala John C, Heck James V, Chang Michael N, Thompson Kathryn L, Chiang Yuan Ching P, Yang Shu Shu: Beta-lactams as antihypercholesterolemics.. Merck & Co, December 27, 1991: EP0462667-A2 (29 worldwide citation)

This application relates to compounds of formula (I), which are useful as antihypercholesterolemic agents.


57
Hoffman Jacob M Jr, Rooney Clarence S, Saari Walfred S, Wai John S, Williams Theresa M, Bamberger Dona L, Jones James H: Inhibitors of hiv reverse transcriptase.. Merck & Co, December 27, 1991: EP0462800-A2 (27 worldwide citation)

Novel pyridones inhibit HIV reverse transcriptase, and are useful in the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, anti-in ...


58
Skiles Jerry W: N-substituted amides.. Boehringer Ingelheim Pharma, May 23, 1990: EP0369391-A2 (27 worldwide citation)

Compounds of the formula are inhibitors of human leukocyte elastase.


59
Matsuishi Naoto, Takeda Haruki, Iizumi Kenichi, Murakami Kiyokazu, Hisamitsu Akira: Imidazo[4,5-b] pyridine compounds, process for preparing same and pharmaceutical compositions containing same.. Tokyo Tanabe Co, January 27, 1988: EP0254588-A1 (26 worldwide citation)

Imidazo[4,5-b]pyridine compounds of the general formula [I] are provided: where R is straight-chain or branched C1-8 alkoxy (which may be substituted with cycloalkyl) or C2-4 fluoroalkyloxy, R is H, methyl or methoxy, and R and R are each H or methyl and may be the same or different. All these compo ...


60
Tschesche Harald Prof Dr, Wenzel Herbert Dr, Schmuck Rainer Dr, Schnabel Eugen Dr: Homologues from aprotinine whose lys 15 amino acid is substituted by other amino acids, process for their preparation and their use as medicaments.. Bayer, February 13, 1985: EP0132732-A2 (26 worldwide citation)

Die Erfindung betrifft Homologe des Aprotinin, in welchen der Lysinrest im aktiven Zentrum des Inhibitors Aprotininin Pos. 15 ausgetauscht ist gegen einen der Rest der Aminosäuren Glycin, L-Alanin, L-Valin, L-Leucin, L-Isoleucin, L-Methionin, L-Arginin, L-[alpha]-Aminobuttersäure, L-Norvalin, L-Norl ...