41
Russell Paul R: Method for expressing foreign genes in schizosaccharomyces pombe and the use in therapeutic formulations of the products, dna constructs and transformant strains of schizosaccharomyces pombe usable in such method and their preparation.. Zymogenetics, May 2, 1985: EP0139383-A1 (37 worldwide citation)

A method is provided for producing heterologous polypeptides in yeast Schizosaccharomyces pombe. DNA constructs are provided for use in this method comprising a segment coding for an S. pombe promoter. A particular construct is provided comprising the S. pombe alcohol dehydrogenase promoter and huma ...


42
Williams Theresa M, Ciccarone Terrence M, Saari Walfred S, Wai John S, Greenlee William J, Balani Suresh K, Goldman Mark E, Theoharides Anthony D: Indoles as inhibitors of hiv reverse transcriptase.. Merck & Co, March 10, 1993: EP0530907-A1 (36 worldwide citation)

Novel indole compounds inhibit HIV reverse transcriptase, and are useful in the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, ...


43
Branca Quirico Dr, Neidhart Werner Dr, Ramuz Henri Prof Dr, Stadler Heinz Dr, Wostl Wolfgang Dr: Amino acid derivatives.. Hoffmann La Roche, March 13, 1991: EP0416373-A2 (36 worldwide citation)

The compounds of the formula in which A, R, R, R, R, R, R, R and R have the meaning given in Claim 1, in the form of optically pure diastereomers, diastereomer mixtures, diastereomeric racemates or mixtures of diastereomeric racemates and pharmaceutically utilisable salts thereof inhibit the action ...


44
Davis Peter David, Hill Christopher Huw, Lawton Geoffrey: Substituted pyrroles.. Hoffmann La Roche, August 29, 1990: EP0384349-A1 (35 worldwide citation)

The pyrrole derivatives of the formula in which R to R, R, X, Y and m have the meaning given in the description, are therapeutically active substances, in particular for use as substances having antiinflammatory, immunological, oncological, bronchopulmonary and cardiovascular activity or as active s ...


45
Bernauer Karl Prof Dr, Borgulya Janos Dr, Bruderer Hans Dr, Da Prada Mose Prof Dr, Zurcher Gerhard: 3,5-disubstituted pyrocatechol derivatives.. Hoffmann La Roche, September 23, 1987: EP0237929-A1 (35 worldwide citation)

The catechol derivatives of the formula in which Ra, Rb and Rc have the meaning given in Claim 1, the ester and ether derivatives which can be hydrolysed under physiological conditions and the pharmaceutically acceptable salts thereof have useful pharmacological properties. They inhibit, in particul ...


46
Molling Karin Prof Dr, Kleemann Heinz Werner Dr, Urbach Hansjorg Dr, Konig Wolfgang Dr, Ruppert Dieter Dr, Winkler Irvin Dr, Paessens Arnold Dr: Use of alpha-aminoboronic acid derivatives in prevention and treatement of viral diseases.. Hoechst, February 14, 1990: EP0354522-A1 (33 worldwide citation)

The invention relates to the use of compounds of the formula I in which A is a radical of the formulae A is absent or is a radical of the formula R, R and R are as defined in the description, and x and y are, independently of one another, -O- or -NR and to the salts thereof for the therapy and proph ...


47
Pomponi Massimo, Pavone Flaminia, Oliverio Alberto, Marta Maurizio, Castellano Claudio, Brufani Mario: Physostigmine derivatives with acetylcholinesterase inhibition properties, and the relative production process.. Consiglio Nazionale Ricerche, September 18, 1985: EP0154864-A1 (33 worldwide citation)

Physostigmine derivatives with acetylcholinesterase inhibition properties, of general formula: in which R can be a linear alkyl of general formula - (CH2)n-CH3 where n varies from 1 to 19, with the proviso that n is not 6, a branched alkyl, a cyclic alkyl or an aryl, and the relative production proc ...


48
Hlasta Dennis John, Ackerman James Howard, Mura Albert Joseph: Saccharin derivative proteolytic enzyme inhibitors.. Sterling Winthrop, June 23, 1993: EP0547708-A1 (32 worldwide citation)

Compounds having the structural formula which inhibit the enzymatic activity of proteolytic enzymes, and processes for preparation thereof, method of use thereof in treatment of degenerative diseases and pharmaceutical compositions thereof are disclosed.


49
Krantz Alexander, Pauls Heinz W, Smith Roger A, Spencer Robin W: Aryloxy and arylacyloxy methyl ketones as thiol protease inhibitors.. Syntex, June 29, 1988: EP0272671-A2 (32 worldwide citation)

Thiol protease inhibitors are disclosed having the formula: or an optical isomer thereof, or a pharmaceutically acceptable salt thereof, wherein: n is 0 or 1; m is 0, 1 or 2; X is H or an N-protecting group; each Y is independently an optionally protected alpha -amino acid residue; R is an optionall ...


50
Kawasaki Glenn Hitoshi, Woodbury Richard Grant: Glycolytic promoters for regulated protein expression: protease inhibitor.. Zymos, March 21, 1984: EP0103409-A2 (32 worldwide citation)

Promoters associated with expression of specific enzymes in the glycolytic pathway are used for expression of alien DNA, particularly yeast promoters known to provide high enzyme levels of enzymes in the glycolytic pathway are employed for expressing a mammalian protein, such as alpha-1-antitrypsin. ...