1
Toufike Kanouni
MarK Adams, Qing Dong, Toufike Kanouni, Stephen W Kaldor, Nicholas Scorah, Michael B Wallace: Mapk/erk kinase inhibitors. Takeda Pharmaceutical Company, Takeda San Diego, May 14, 2009: US20090124595-A1

Compounds of the following formula are provided for use with MEK: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using sa ...


2
Toufike Kanouni
Qing Dong, Xianchang Gong, Stephen W Kaldor, Toufike Kanouni, Nicholas Scorah, Michael B Wallace, Feng Zhou: Mapk/erk kinase inhibitors. Takeda San Diego, October 16, 2008: US20080255160-A1

Compounds of the following formula are provided for use with MEK: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using sa ...


3
Sigal Irving S, Huff Joel R, Darke Paul L, Vacca Joseph P, Young Steven D, Desolms S Jane, Thompson Wayne J, Lyle Terry A, Graham Samuel L, Ghosh Arun K: Hiv protease inhibitors useful for the treatment of aids.. Merck & Co, October 18, 1989: EP0337714-A2 (242 worldwide citation)

Compounds of the form A-G-B-B-J wherein A is an amine protecting group commonly employed in peptide synthesis, G a dipeptide isostere, B an amino acid or analog thereof, and J a small terminal group are described. These compounds are useful in the inhibition of HIV protease, the prevention or treatm ...


4
Higuchi Naoki, Saitoh Masayuki, Shibata Hiroshi: Proteinase inhibitor.. Suntory, October 24, 1990: EP0393457-A1 (170 worldwide citation)

A proteinase inhibitory compound represented by the following general formula (1): wherein R1 represents a straight-chain or branched acyl group having 2 to 10 carbon atoms, a branched-, cyclic- or polycyclic-alkyloxycarbonyl group having 4 to 15 carbon atoms, a substituted- or unsubstituted-benzylo ...


5
Cerami Anthony, Kawakami Masanobu: Anabolic activity modulator and uses thereof.. Univ Rockefeller, March 4, 1987: EP0212489-A2 (154 worldwide citation)

A modulator material is disclosed which has been isolated from macrophage cells that have been incubated with a stimulator material from an invasive stimulus. The modulator material comprises a protein that exhibits the ability to substantially completely suppress the activity of the anabolic enzyme ...


6
Neustadt Bernard R, Gold Elijah H, Smith Elizabeth M: Carboxyalkyl dipeptides, processes for their production and pharmaceutical compositions containing them.. Schering, May 5, 1982: EP0050800-A1 (146 worldwide citation)

Disclosed are novel carboxyalkyl dipeptides which are useful as inhibitors of angiotensinconverting enzyme and as antihypertensive agents, having the formula and the pharmaceuticallv acceptable salts thereof, wherein R and R are for example hydroxy, lower alkoxy or aryllower-4 alkoxy; R is for examp ...


7
Kettner Charles Adrian, Shenvi Ashokkumar Bhikkappa: Peptide boronic acid inhibitors of trypsin-like proteases.. Du Pont, December 7, 1988: EP0293881-A2 (124 worldwide citation)

Peptides comprising C-terminal boronic acid derivatives of lysine, ornithine, and arginine, homoarginine and corresponding isothiouronium analogs thereof, of the formula are reversible inhibitors of trypsin-like serine proteases such as thrombin, plasma kallikrein and plasmin.


8
Bey Philippe, Angelastro Michael, Mehdi Shujaath: Novel peptidase inhibitors.. Merrell Dow Pharma, April 11, 1990: EP0363284-A2 (98 worldwide citation)

This invention relates to analogs of peptidase substrates in which the nitrogen atom of the scissile amide gorup of the substrate peptide has been replaced by H or a substituted carbonyl moiety. The contemplated peptidase inhibitors of the foregoing enzymes are selected from the generic formula R1NH ...


9
Bey Philippe, Angelastro Michael, Mehdi Shujaath: Novel peptidase inhibitors.. Merrell Dow Pharma, April 18, 1990: EP0364344-A2 (90 worldwide citation)

This invention relates to analogs of peptidase substrates in which the nitrogen atom of the scissile amide group of the substrate peptide has been replaced by a substituted malonyl moiety. The contemplated peptidase inhibitors of the foregoing enzymes are selected from the generic formula the hydrat ...


10
Metternich Rainer: Peptide boronic acid derivatives having protease inhibiting activity.. Sandoz, Sandoz, Sandoz, February 19, 1992: EP0471651-A2 (84 worldwide citation)

Borolysine peptidomimetics of formula I wherein W, Y, R4, R5, Q1 and Q2 are defined in claim 1 are potent thrombin inhibitors.