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St├ęphane De Lombaert
Rajagopal Bakthavatchalam, Timothy M Caldwell, Bertrand L Chenard, St├ęphane De Lombaert, Kevin J Hodgetts: Substituted quinolin-4-ylamine analogues. Neurogen Corporation, Edward Angell Palmer & Dodge, November 19, 2009: US20090286767-A1

Substituted quinolin-4-ylamine analogues are provided. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion ...


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Keith Everett
Keith Everett: Led array for illuminating cell well plates and automated rack system for handling the same. Biolex, Alston & Bird, Bank Of America Plaza, August 28, 2003: US20030162288-A1

An assembly for promoting the growth of plant tissues that includes a plurality of plates each defining an array of wells wherein each of the wells contains a tissue sample. Support for the plates is provided by a rack having a plurality of vertically stacked shelves that may include one or more reg ...


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Winter Gregory Paul: Recombinant antibodies and methods for their production.. Winter Gregory Paul, September 30, 1987: EP0239400-A2 (917 worldwide citation)

An altered antibody is produced by replacing the complementarity determining regions (CDRs) of a variable region of an immunoglobulin (Ig) with the CDRs from an Ig of different specificity using recombinant DNA techniques. The gene coding sequences for producing the altered antibody may be produced ...


4
Morrison Sherie L, Herzenberg Leonard A, Oi Vernon T: Chimeric receptors by dna splicing and expression.. Univ Leland Stanford Junior, March 5, 1986: EP0173494-A2 (394 worldwide citation)

Chimeric multi-subunit receptors are provided involving a binding region resulting from the organization of two subunit chains and a non-binding region which may have physiological significance. Particularly, chimeric immunoglobulins are provided having variable regions from one species and constant ...


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Taniguchi Masaru, Kurosawa Yoshikazu Lions Mansi, Sugita Kou Zou: Process for the production of a chimera monoclonal antibody.. Japan Res Dev, February 19, 1986: EP0171496-A2 (327 worldwide citation)

This invention concerns a animal-human chimera monoclonal antibody whose side-effects such as anaphylaxis and serum sickness are thought to be greatly reduced when it is administered to man. The chimera monoclonal antibody consists of a variable region derived from experimental animals and a constan ...


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Leemans Jan, Botterman Johan, de Block Marc, Thompson Charles, Mouva Rao: Plant cells resistant to glutamine synthetase inhibitors, made by genetic engineering.. Plant Genetic Systems, Biogen, October 21, 1987: EP0242246-A1 (244 worldwide citation)

The invention relates to a DNA fragment containing a determined gene, the expression of which inhibits the antibiotic and herbicidal effects of Bialaphos and related products. It also relates to recombinant vectors, containing such DNA fragment, which enable this protective gene to be introduced and ...


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Greve Henri Marcel Jozef de, Salgado Maria Benita Leonor Fe, Montagu Marc Charles Ernest Va, Vaeck Mark Albert, Zabeau Marcus Florent Oscar, Leemans Jan Jozef August, Hofte Hermanus Fransiscus Paul: Modifying plants by genetic engineering to combat or control insects.. Plant Genetic Systems, September 3, 1986: EP0193259-A1 (224 worldwide citation)

Novel transformation vectors containing novel chimeric genes allow the introduction of exogenous DNA fragments coding for polypeptide toxins produced by Bacillus thuringiensis or having substantial sequence homology to a gene coding for a polypeptide toxin as described herein and expression of the c ...


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Winter Gregory Paul: Chimeric antibodies. Winter Gregory Paul, October 7, 1987: GB2188638-A (222 worldwide citation)

An altered antibody is produced by replacing the complementarity determining regions (CDRs) of a variable region of an immunoglobulin (Ig) with the CDRs from an Ig of different specificity, using recombinant DNA techniques. The gene coding sequences for producing the altered antibody may be produced ...


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Gordon Katherine, Groet Suzanne: Transgenic animals secreting desired proteins into milk.. Integrated Genetics, April 20, 1988: EP0264166-A1 (221 worldwide citation)

A DNA sequence contains a gene encoding a protein, the gene being under the transcriptional control i n the DNA sequence of a mammalian milk protein promoter which does not naturally control the transcription of the gene, such DNA sequence including DNA enabling secretion of the protein.