1
Adam Heller, Michael V Pishko: Electrochemical analyte measurement system. E Heller & Company, Merchant & Gould P C, September 19, 2000: US06121009 (984 worldwide citation)

A small diameter flexible electrode designed for subcutaneous in vivo amperometric monitoring of glucose is described. The electrode is designed to allow "one-point" in vivo calibration, i.e., to have zero output current at zero glucose concentration, even in the presence of other electroreactive sp ...


2
Adam Heller, Ruben Maidan: Interferant eliminating biosensor. E Heller & Company, Pravel Hewitt Kimball & Krieger, October 18, 1994: US05356786 (941 worldwide citation)

Interferant eliminating analyte sensors and sensing process prevent erroneous assays. Glucose electrodes were coated with an oxidizing enzyme (peroxidase) which allows hydrogen peroxide to selectively oxidize ascorbate, urate, bilirubin, and acetaminophenol in the presence of glucose. Hydrogen perox ...


3
Adam Heller, Michael V Pishko: Electrochemical analyte measurement system. E Heller & Company, Merchant & Gould P C, July 4, 2000: US06083710 (924 worldwide citation)

A small diameter flexible electrode designed for subcutaneous in vivo amperometric monitoring of glucose is described. The electrode is designed to allow "one-point" in vivo calibration, i.e., to have zero output current at zero glucose concentration, even in the presence of other electroreactive sp ...


4
Adam Heller, Ruben Maidan: Interferant eliminating biosensors. E Heller & Company, Pravel Hewitt Kimball & Krieger, November 16, 1993: US05262305 (824 worldwide citation)

A biosensor including an interferant-eliminating catalyst and method for analyzing an analyte in a biological sample is disclosed.


5
Michael J Heller, Eugene Tu: Active programmable electronic devices for molecular biological analysis and diagnostics. Nanogen, Lyon & Lyon, February 25, 1997: US05605662 (698 worldwide citation)

A self-addressable, self-assembling microelectronic device is designed and fabricated to actively carry out and control multi-step and multiplex molecular biological reactions in microscopic formats. These reactions include nucleic acid hybridization, antibody/antigen reaction, diagnostics, and biop ...


6
Ian A Shanks, Alan M Smith, Claes I Nylander: Device for use in chemical test procedures. Internationale Octrooi Maatschappij Octropa, Cushman Darby & Cushman, August 25, 1992: US05141868 (652 worldwide citation)

A specifically-reactive sample-collecting and testing device possessing a cavity or cavities each having a dimension small enough to enable sample liquid to be drawn into the cavity by capillary action, wherein said cavity includes an electrode structure for making measurements of one or more electr ...


7
Patrick O Brown, Tidhar Dari Shalon: Methods for fabricating microarrays of biological samples. The Board of Trustees of the Leland Stanford Junior University, Arnold White & Durkee, September 15, 1998: US05807522 (603 worldwide citation)

A method and apparatus for forming microarrays of biological samples on a support are disclosed. The method involves dispensing a known volume of a reagent at each selected array position, by tapping a capillary dispenser on the support under conditions effective to draw a defined volume of liquid o ...


8
Matthew K Musho, J Oakey Noell, Pius H Tse: Conductive sensors and their use in diagnostic assays. Miles, Roger N Coe, Jerome L Jeffers, April 13, 1993: US05202261 (532 worldwide citation)

A conductive sensor and its use in a diagnostic assay are disclosed. The miniaturized conductive sensor, utilizing a conducting polymer, is used in a diagnostic device to determine the presence or concentration of a predetermined analyte in a liquid test sample, wherein the predetermined analyte, li ...


9
Toshihiko Yoshioka, Mariko Kawaguri, Shiro Nankai: Preparation of biosensor having a layer containing an enzyme, electron acceptor and hydrophilic polymer on an electrode system. Matsushita Electric Industrial, Wenderoth Lind & Ponack, July 20, 1993: US05229282 (442 worldwide citation)

The present invention relates to a process of preparation of a biosensor comprising forming an electrode system mainly containing carbon on an insulating base plate, treating the surface of electrode system with an organic solvent, and then arranging a reaction layer on the electrode system to give ...


10
Hugh P Bennetto, Gerard M Delaney, Jeremy R Mason, Christopher F Thurston, John L Stirling, David R DeKeyzer: Immobilized enzyme electrodes. Cambridge Life Sciences, St Onge Steward Johnston & Reens, November 13, 1990: US04970145 (423 worldwide citation)

Enzyme electrodes are disclosed which are capable of responding amperometrically to the catalytic activity of the enzyme in the presence of its respective substrate and comprising the enzyme immobilized or adsorbed onto the surface of an electrically conductive support member which consists of or co ...