1
Roger DiPaolo
Nathan K Weiner, Patrick J Odoy, Eric Schultz, Mark Jones, James Overbeck, Herman Deweerd, David A Stura, Albert Bukys, Tim Woolaver, Thomas P Regan, David Bradbury, Eric Earl McKenzie, Roger DiPaolo, Christopher Miles, Joel M Katz, Ksenia Oleink Ovod: System, method, and product for scanning of biological materials. Affymetrix, Thomas J Siepmann, January 18, 2011: US07871812 (6 worldwide citation)

An embodiment of a scanning system is described including optical elements that direct an excitation beam at a probe array, detectors that receive reflected intensity data responsive to the excitation beam, where the reflected intensity data is responsive to a focusing distance between an optical el ...


2
Mark C Shults, Christopher C Capelli, Stuart J Updike: Biological fluid measuring device. Markwell Medical Institute, Olson & Hierl, July 12, 1988: US04757022 (934 worldwide citation)

A biological fluid measuring device for determining the presence and the amounts of substances in a biological fluid without the need for dilution of the fluid comprises a main housing including electronic circuit means and at least one elecrode, and a cartridge having a membrane. The cartridge is r ...


3
Rolfe C Anderson, Robert J Lipshutz, Richard P Rava, Stephen P A Fodor: Integrated nucleic acid diagnostic device. Affymetrix, Townsend & Townsend & Crew, July 13, 1999: US05922591 (646 worldwide citation)

The present invention provides a miniaturized integrated nucleic acid diagnostic device and system. The device of the invention is generally capable of performing one or more sample acquisition and preparation operations, in combination with one or more sample analysis operations. For example, the d ...


4
Patrick O Brown, Tidhar Dari Shalon: Methods for fabricating microarrays of biological samples. The Board of Trustees of the Leland Stanford Junior University, Arnold White & Durkee, September 15, 1998: US05807522 (603 worldwide citation)

A method and apparatus for forming microarrays of biological samples on a support are disclosed. The method involves dispensing a known volume of a reagent at each selected array position, by tapping a capillary dispenser on the support under conditions effective to draw a defined volume of liquid o ...


5
Leland Clark Jr: Implantable gas-containing biosensor and method for measuring an analyte such as glucose. Children s Hospital Medical Center, Wood Herron & Evans, July 14, 1987: US04680268 (547 worldwide citation)

The present invention relates to a novel implantable biosensor and method for sensing products, such as hydrogen peroxide, generated from an enzymatic reaction between an analyte, like glucose, and an enzyme in the presence of oxygen. The novel implantable biosensor is uniquely equipped with an encl ...


6
Leland C Clark Jr: Implantable gas-containing biosensor and method for measuring an analyte such as glucose. Children s Hospital Medical Center, Wood Herron & Evans, January 26, 1988: US04721677 (543 worldwide citation)

The present invention relates to a novel implantable biosensor and method for sensing products, such as hydrogen peroxide, generated from an enzymatic reaction between an analyte, like glucose, and an enzyme in the presence of oxygen. The novel implantable biosensor is uniquely equipped with an encl ...


7
Matthew K Musho, J Oakey Noell, Pius H Tse: Conductive sensors and their use in diagnostic assays. Miles, Roger N Coe, Jerome L Jeffers, April 13, 1993: US05202261 (532 worldwide citation)

A conductive sensor and its use in a diagnostic assay are disclosed. The miniaturized conductive sensor, utilizing a conducting polymer, is used in a diagnostic device to determine the presence or concentration of a predetermined analyte in a liquid test sample, wherein the predetermined analyte, li ...


8
Michael J Heller, Eugene Tu, William F Butler: Molecular biological diagnostic systems including electrodes. Nanogen, Lyon & Lyon, May 27, 1997: US05632957 (531 worldwide citation)

A system for performing molecular biological diagnosis, analysis and multi-step and multiplex reactions utilizes a self-addressable, self-assembling microelectronic system for actively carrying out controlled reactions in microscopic formats. These reactions include most molecular biological procedu ...


9
Rolfe C Anderson, Robert J Lipshutz, Richard P Rava, Stephen P A Fodor: Miniaturized genetic analysis systems and methods. Affymetrix, Townsend and Townsend and Crew, January 2, 2001: US06168948 (439 worldwide citation)

The present invention provides a miniaturized integrated nucleic acid diagnostic device and system which includes a nucleic acid extraction zone including nucleic acid binding sites.


10
Adam Heller, Ioanis Katakis, Ling Ye: Biosensor including chemically modified enzymes. Merchant Gould Smith Edell Welter & Schmidt, August 6, 1996: US05543326 (391 worldwide citation)

Oxidoreductases are chemically modified so as to change their net charge at a given pH. Through such modification the adsorption of the enzymes on surfaces, their retention in similarly or oppositely charged polymer membranes and their binding with similarly or oppositely charged macromolecules, par ...