1
Richard A Berg, Frederick H Silver, James M Pachence: Collagen matrix beads for soft tissue repair. MediMatrix, Michael Ebert, June 6, 1989: US04837285 (272 worldwide citation)

Collagen-based compositions for augmenting soft tissue, wound dressings, implants, injectable formulations or other drug delivery systems, comprising resorbable collagen matrix beads, the beads having an average pore size of from 50 to 350 microns, and the collagen comprising from 1 to 30% by volume ...


2
Kenneth C Hou, Tung Ping D Liao, Robert Rohan: Affinity matrices of modified polysaccharide supports. Cuno, October 22, 1991: US05059654 (261 worldwide citation)

The invention is directed to a modified polysaccharide material which comprises: (1) polysaccharide covalently bonded to a synthetic polymer; (2) the synthetic polymer being made from (a) a polymerizable compound which is capable of being covalently coupled directly or indirectly to said polysacchar ...


3
Frederick A Silver, Richard A Berg, David E Birk, Kevin Weadock, Conrad Whyne: Biodegradable matrix and methods for producing same. University of Medicine & Dentistry of New Jersey, Weiser & Stapler, October 27, 1987: US04703108 (254 worldwide citation)

There are disclosed processes for preparing biodegradable collagen-based matrices in sponge or sheet form wherein in one embodiment a collagen-based material including a collagen selected from the group consisting of types I, II and II collagens is freeze dried to form a collagen-based sponge which ...


4
Frederick H Silver, Richard A Berg, Charles J Doillon, Kevin Weadock, Conrad Whyne: Biodegradable matrix and methods for producing same. University of Medicine and Dentistry of New Jersey, Weiser & Stapler, November 13, 1990: US04970298 (191 worldwide citation)

This invention relates to a biodegradable collagen matrix having a pore size and morphology which enhances the healing of a wound. It further relates to a process for preparing the matrix. One embodiment of the invention comprises a biodegradable matrix which comprises collagen, hyaluronic acid and ...


5
Nnochiri N Ekwuribe: Conjugation-stabilized polypeptide compositions, therapeutic delivery and diagnostic formulations comprising same, and method of making and using the same. Protein Delivery, Steven J Hultquist, Fran S Wasserman, October 25, 1994: US05359030 (165 worldwide citation)

A stabilized conjugated peptide complex comprising a peptide conjugatively coupled to a polymer including lipophilic and hydrophilic moieties, wherein the peptide may for example be selected from the group consisting of insulin, calcitonin, ACTH, glucagon, somatostatin, somatotropin, somatomedin, pa ...


6
James E Woiszwillo, Larry R Brown, Terrence L Scott, Jie Di, Judith Sudhalter, Charles D Blizzard: Macromolecular microparticles and methods of production and use. Epic Therapeutics, Jones & Askew, July 18, 2000: US06090925 (152 worldwide citation)

Microparticles formed by mixing a macromolecule with a polymer at a pH near the isoelectric point of the macromolecule and incubating the mixture in the presence of an energy source for a predetermined length of time. The microparticles are composed of homogeneously distributed, intertwined macromol ...


7
Birendra K Patnaik: Bonding bio-active materials to substrate surfaces. Meadox Medicals, Hoffman & Baron, March 17, 1998: US05728751 (149 worldwide citation)

A medical device having a bio-active coating is prepared by providing a polymeric substrate having hydroxyl and/or amine functionality on a surface thereof and applying the bio-active coating to the surface. The bio-active coating is the reaction product of two different reactions. The first reactio ...


8
James E Woiszwillo, Larry R Brown, Terrence L Scott, Jie Di, Judith Sudhalter, Charles D Blizzard, Frank J Riske: Macromolecular microparticles and methods of production and use. Epic Therapeutics, Jones & Askew, November 9, 1999: US05981719 (132 worldwide citation)

Microparticles formed by mixing a macromolecule with a polymer at a pH near the isoelectric point of the macromolecule and incubating the mixture in the presence of an energy source for a predetermined length of time. The microparticles are composed of homogeneously distributed, intertwined macromol ...


9
Nicholas Kowanko: Adhesive composition and method. Fredrikson & Byron, January 31, 1995: US05385606 (130 worldwide citation)

An adhesive composition, primarily intended as a tissue adhesive, comprised of cross-linked proteinaceous material, and methods for its use.


10
Ronald Yamamoto: Method of forming chelated collagen having bactericidal properties. Vitaphore Corporation, Flehr Hohbach Test Albritton & Herbert, July 11, 1989: US04847049 (123 worldwide citation)

A method is provided for protecting renatured collagen against bacterial and fungal attack by contacting the collagen with a silver ion-containing solution at a pH from 4.0 to 9.0 and exposing the silver-chelated collagen to ultraviolet radiation.



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