1
Kunsch Charles A, Choi Gil H, Barash Steven C, Dillon Patrick J, Fannon Michael R, Rosen Craig A: Staphylococcus aureus polynucleotides and sequences. Human Genome Sciences, July 30, 1997: EP0786519-A2 (232 worldwide citation)

The present invention provides polynucleotide sequences of the genome of Staphylococcus aureus, polypeptide sequences encoded by the polynucleotide sequences, corresponding polynucleotides and polypeptides, vectors and hosts comprising the polynucleotides, and assays and other uses thereof. The pres ...


2
Greve Henri Marcel Jozef de, Salgado Maria Benita Leonor Fe, Montagu Marc Charles Ernest Va, Vaeck Mark Albert, Zabeau Marcus Florent Oscar, Leemans Jan Jozef August, Hofte Hermanus Fransiscus Paul: Modifying plants by genetic engineering to combat or control insects.. Plant Genetic Systems, September 3, 1986: EP0193259-A1 (223 worldwide citation)

Novel transformation vectors containing novel chimeric genes allow the introduction of exogenous DNA fragments coding for polypeptide toxins produced by Bacillus thuringiensis or having substantial sequence homology to a gene coding for a polypeptide toxin as described herein and expression of the c ...


3
Nakagawa Satochi, Mizoguchi Hiroshi, Ando Seiko, Hayashi Mikiro, Ochiai Keiko, Yokoi Haruhiko, Tateishi Naoko, Senoh Akihiro, Ikeda Masato, Ozaki Akio: Novel polynucleotides. Kyowa Hakko Kogyo, June 20, 2001: EP1108790-A2 (180 worldwide citation)

Novel polynucleotides derived from microorganisms belonging to coryneform bacteria and fragments thereof, polypeptides encoded by the polynucleotides and fragments thereof, polynucleotide arrays comprising the polynucleotides and fragments thereof, recording media in which the nucleotide sequences o ...


4
Fei Mao, Wai Yee Leung, Richard P Haugland: Sulfonated xanthene derivatives. Molecular Probes, Anton E Skaugset, October 10, 2000: US06130101 (166 worldwide citation)

The present invention describes xanthene dyes, including rhodamines, rhodols and fluoresceins that are substituted one or more times by a sulfonic acid or a salt of a sulfonic acid. The dyes of the invention, including chemically reactive dyes and dye-conjugates are useful as fluorescent probes, par ...


5
Kucherlapati Raju, Jakobovits Aya: Generation of xenogeneic antibodies.. Cell Genesys, January 2, 1992: EP0463151-A1 (118 worldwide citation)

The subject invention provides non-human mammalian hosts characterized by inactivated endogenous Ig loci. The hosts are produced by repetitive transformations of embryonic stem cells by homologous recombination, preferably in conjunction with breeding. Different strategies are employed for recombina ...


6
Insel Richard Alan, Gigliotti Francis: Human monoclonal antibodies against bacterial toxins.. Univ Rochester, April 18, 1984: EP0105804-A2 (71 worldwide citation)

The production of stable hybrid cell lines that secrete human monoclonal antibodies against bacterial toxins by fusing post-immunization human peripheral blood lymphocytes with nonsecretor mouse myeloma cells is described. Using the method, protective monoclonal antibodies against tetanus toxin and ...


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Cecile Casterman, Raymond Hamers: Immunoglobulins devoid of light chains. Vrije Universiteit Brussel, Finnegan Henderson Farabow Garrett & Dunner L, November 24, 1998: US05840526 (56 worldwide citation)

There is provided an isolated immunoglobulin comprising two heavy polypeptide chains sufficient for the formation of a complete antigen binding site or several antigen binding sites, wherein the immunoglobulin is further devoid of light polypeptide chains.


9
Reichard Raymond, Brown James Raymond, Lawlor Elizabeth J: Aspartyl trna synthetase from chlamydia trachomatis. Smithkline Beecham, Smithkline Beecham, January 27, 1999: EP0893494-A2 (55 worldwide citation)

The invention provides aspS polypeptides and DNA (RNA) encoding aspS polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing aspS polypeptides to screen for antibacterial compounds.


10
Reichard Raymond, Brown James Raymond, Lawlor Elizabeth J: Histidyl trna synthetase from chlamydia trachomatis. Smithkline Beecham, Smithkline Beecham, January 27, 1999: EP0893496-A2 (55 worldwide citation)

The invention provides hisS polypeptides and DNA (RNA) encoding hisS polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing hisS polypeptides to screen for antibacterial compounds.