1
Morrison Sherie L, Herzenberg Leonard A, Oi Vernon T: Chimeric receptors by dna splicing and expression.. Univ Leland Stanford Junior, March 5, 1986: EP0173494-A2 (394 worldwide citation)

Chimeric multi-subunit receptors are provided involving a binding region resulting from the organization of two subunit chains and a non-binding region which may have physiological significance. Particularly, chimeric immunoglobulins are provided having variable regions from one species and constant ...


2
Cabilly Shmuel, Holmes William Evans, Wetzel Ronald Burnell, Heyneker Herbert Louis, Riggs Arthur Dale: Recombinant immunoglobulin preparations, methods for their preparation, dna sequences, expression vectors and recombinant host cells therefor.. Genentech, Hope City, November 14, 1984: EP0125023-A1 (379 worldwide citation)

Recombinant DNA techniques are used to produce both immunoglobulins which are analogous to those normally found in vertebrate systems and to take advantage of these gene modification techniques to construct chimeric or other modified forms.


3
Esohe Ekinaduese Idusogie, Leonard G Presta, Michael George Mulkerrin: Polypeptide variants. Genentech, Wendy M Lee, February 27, 2001: US06194551 (344 worldwide citation)

A variant of a polypeptide comprising a human IgG Fc region is described, which variant comprises an amino acid substitution at amino acid position 329, or at two or all of amino acid positions 329, 331 and 322 of the human IgG Fc region. Such variants display altered effector function. For example, ...


4
Bosslet Klaus Dr, Hermentin Peter Dr, Seemann Gerhard Dr, Kuhlmann Ludwig Dr, Steinstraesser Axel Dr Dr: Bispecific and oligospecific, mono- and oligovalent receptors, production and applications thereof.. Behringwerke, December 27, 1990: EP0404097-A2 (298 worldwide citation)

The invention relates to bispecific and oligospecific, mono- and oligovalent receptors which are prepared by genetic manipulation by fusion of DNA coding for F(ab) fragments of the antibodies of two or more different specificities, using suitable linkers. Preferably one of these specificities is dir ...


5
Boss Michael Alan, Kenten John Henry, Emtage John Spencer, Wood Clive Ross: Processes for the production of multichain polypeptides or proteins.. Celltech, October 3, 1984: EP0120694-A2 (276 worldwide citation)

This invention relates to multichain polypeptides or proteins and processes for their production in cells of host organisms which have been transformed by recombinant DNA techniques. According to a first aspect of the present invention, there is provided a process for producing a heterologous multic ...


6
Leemans Jan, Botterman Johan, de Block Marc, Thompson Charles, Mouva Rao: Plant cells resistant to glutamine synthetase inhibitors, made by genetic engineering.. Plant Genetic Systems, Biogen, October 21, 1987: EP0242246-A1 (244 worldwide citation)

The invention relates to a DNA fragment containing a determined gene, the expression of which inhibits the antibiotic and herbicidal effects of Bialaphos and related products. It also relates to recombinant vectors, containing such DNA fragment, which enable this protective gene to be introduced and ...


7
Houghton Michael, Choo Qui Lim, Kuo George: Nanbv diagnostics and vaccines.. Chiron, May 31, 1989: EP0318216-A1 (229 worldwide citation)

A family of cDNA sequences derived from hepatitis C virus (HCV) are provided. These sequences encode antigens which react immunologically with antibodies present in individuals with non-A non-B hepatitis (NANBH), but which generally are absent from individuals infected with hepatitis A virus (HAV) o ...


8
Edward J Rebar, Carl O Pabo: Zinc finger proteins with high affinity new DNA binding specificities. Massachusetts Institute of Technology, Hamilton Brook Smith & Reynolds P C, August 4, 1998: US05789538 (226 worldwide citation)

Described is a polypeptide comprising one or more zinc fingers. The polypeptide binds to new polynucleotide subsites with high affinity and consequently has a binding specificity that differs from wild type zinc finger proteins. The binding occurs through contacts between certain amino acid residues ...


9
Houghton Michael, Choo Qui Lim, Kuo George: Nanbv diagnostics and vaccines.. Chiron, September 19, 1990: EP0388232-A1 (204 worldwide citation)

A new virus, Hepatitis C virus (HCV), which has proven to be the major etiologic agent of blood-borne NANBH, was discovered by Applicant. The initial work on this virus, which includes a partial genomic sequence of the prototype HCV isolate, is described in EPO Pub. No. 318,216, and PCT Pub. No. WO/ ...


10
Bruce A Beutler, Karsten Peppel, David F Crawford: DNA encoding a chimeric polypeptide comprising the extracellular domain of TNF receptor fused to IgG, vectors, and host cells. Board of Regents The University of Texas System, Arnold White & Durkee, September 5, 1995: US05447851 (195 worldwide citation)

The invention relates generally to DNA sequences encoding chimeric polypeptides comprising extracellular portions of cytokine receptor polypeptides attached to a sequence encoding portions of IgG polypeptides. The invention relates generally, as well, to DNA sequences encoding chimeric polypeptides ...