1
Frank F Davis, Theodorus Van Es, Nicholas C Palczuk: Non-immunogenic polypeptides. Omri M Behr, December 18, 1979: US04179337 (1385 worldwide citation)

Polypeptides such as enzymes and insulin are coupled to polyethylene glycol or polypropropylene glycol having a molecular weight of 500 to 20,000 daltons to provide a physiologically active non-immunogenic water soluble polypeptide composition. The polyethylene glycol or polypropylene glycol protect ...


2
Gautam Mitra: Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer. Miles Laboratories, Lester E Johnson, January 29, 1985: US04496689 (432 worldwide citation)

There is disclosed a process for producing a covalently attached alpha-1-proteinase inhibitor - water soluble polymer complex useful for pulmonary emphysema therapy, a covalently attached alpha-1-proteinase inhibitor - water soluble polymer complex produced by the process, a composition thereof in a ...


3
Thomas P Hopp: Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity. New York Blood Center, Sprung Horn Kramer & Woods, November 19, 1985: US04554101 (426 worldwide citation)

An immunoglobulin is provided which consists essentially of a mono-specific, hetero-molecular antibody which is mono-specific to a single antigenic or allergenic determinant. The antibody is specific to the H-epitope of a protein antigen or allergen. The H-epitope is defined by a sequence of at leas ...


4
Endre A Balazs: Ultrapure hyaluronic acid and the use thereof. Biotrics, Hubbell Cohen Stiefel & Gross, February 27, 1979: US04141973 (286 worldwide citation)

An ultra-pure, high molecular weight hyaluronic acid fraction which is characterized by the absence of significant cellular infiltration of the vitreous and anterior chamber, absence of significant flare in the aqueous humor, absence of significant haze or flare in the vitreous and absence of pathol ...


5
Marshall R Urist: Biodegradable porous ceramic delivery system for bone morphogenetic protein. The Regents of the University of California, Kenyon & Kenyon, June 24, 1986: US04596574 (276 worldwide citation)

Disclosed is a biodegradable porous ceramic delivery system useful for delivery of bone morphogenic protein (BMP) to viable tissue and to induce formation of new bone therein. The delivery composite is substantially pure BMP in combination with a biodegradable porous ceramic (sintered), e.g. beta-tr ...


6
Dieter Banauch, Wolfgang Brummer, Wolfgang Ebeling, Roland Helger, Norbert Hennrich, Hermann Lang: Enzymatic determination of glucose. Merck Patent Gesellschaft mit beschrankter Haftung, Millen Raptes & White, June 22, 1976: US03964974 (266 worldwide citation)

Glucose is rapidly ad quantitatively determined with an analytical agent containing glucose dehydrogenase having an activity of at least 2 .mu./mg and NADH.sub.2 oxidase activity less than 0.1%, a pyridine coenzyme, a buffer and mutarotase to increase spontaneous mutarotation of alpha-glucose to bet ...


7
Marshall R Urist: Biodegradable organic polymer delivery system for bone morphogenetic protein. University of California, January 7, 1986: US04563489 (254 worldwide citation)

Disclosed is a biodegradable polylactic acid polymer delivery system for delivery of bone morphogenic protein (BMP) to induce formation of new bone in viable tissue. The delivery composition is substantially pure BMP in combination with a biodegradable polylactic acid polymer and it is prepared by a ...


8
Erkki Ruoslahti, Michael Pierschbacher: Tetrapeptide. La Jolla Cancer Research Foundation, Hubbard Stetina & Brunda, March 25, 1986: US04578079 (249 worldwide citation)

The peptide X-Arg-Gly-Asp-R-Y wherein X is H or at least one amino acid and Y is OH or at least one amino acid, and R is an amino acid selected from Thr or Cys, or other amino acid, having the same cell-attachment activity as fibronectin and the peptide X-Arg-Gly-Asp-Ser-Y, wherein X and Y, having s ...


9
Marshall R Urist: Bone morphogenetic protein process. The Regents of the University of California, Kenyon & Kenyon, October 13, 1981: US04294753 (247 worldwide citation)

The process of separating bone morphogenetic protein (BMP) from bone tissue comprising the steps of demineralizing bone tissue; treating the demineralized bone tissue under aqueous conditions with a water soluble neutral salt and a solubilizing agent for the BMP, the agent being selected from the gr ...


10
Paula J Shadle, Kirston E Koths, Margaret Moreland, Nandini Katre: Conjugation of polymer to colony stimulating factor-1. Cetus Corporation, Albert P Halluin, July 11, 1989: US04847325 (212 worldwide citation)

A biologically active CSF-1 protein is selectively conjugated via certain amino acid residues or carbohydrate moieties to a water-soluble polymer selected from polyethylene glycol or polypropylene glycol homopolymers, polyoxyethylated polyols, or polyvinyl alcohol. The resulting conjugated CSF-1 is ...



Click the thumbnails below to visualize the patent trend.