Blumbach Jurgen Dr, Durckheimer Walter Dr, Reden Jurgen Dr, Seliger Hubert: Process for acylating 7aminocephem derivatives.. Hoechst, July 11, 1979: EP0002774-A1 (155 worldwide citation)

1. A process for the acylation of 7-amino-cephem derivatives, which comprises converting an acylating component of the formula I see diagramm : EP0002774,P20,F1 in which R**1 is alkyl having from 1 to 4 carbon atoms, phenyl, 2-furyl or thiazolyl of the formula see diagramm : EP0002774,P20,F2 in whic ...



Martin Christopher Cook, Gordon Ian Gregory, Janice Bradshaw: Cephalosporins having (.alpha.-etherified oximino)acylamido groups at the 7-position. Glaxo Laboratories, Bacon & Thomas, July 27, 1976: US03971778 (54 worldwide citation)

The invention provides novel antibiotic compounds which are 7.beta.-acylamidoceph-3-em-4-carboxylic acids, and non-toxic derivatives thereof characterized in that the acylamido group has the structure ##EQU1## where R is a hydrogen atom or an organic group and R.sup.a is an etherifying monovalent or ...

Eaton Michael Anthony William, Pratt Andrew John, Alexander Rikki Peter: Immunoconjugates and prodrugs and their use in association for drug delivery.. Celltech, October 17, 1990: EP0392745-A2 (49 worldwide citation)

A drug delivery system is described in which an immunoconjugate and a prodrug are used in association with each other to deliver a drug to a host target site such as a tumour. The immunoconjugate comprises an antibody or antibody fragment to which is attached a beta -lactamase or an active fragment ...


Chauvette Robert R: Alpha-aminoacyl-3-halo cephalosporins. Eli Lilly and Company, Scanlon William B, Smith Everet F, December 9, 1975: US3925372 (40 worldwide citation)

.alpha.-Aminoacyl-3-halo cephalosporins represented by the formula ##SPC1##Wherein R is phenyl, substituted phenyl, thienyl or furyl; and X is fluoro, chloro, bromo or iodo and the non-toxic pharmaceutically acceptable salts thereof are valuable, orally effective antibiotics.


Cephalosporin compounds. Glaxo Lab, June 25, 1975: GB1399086-A (39 worldwide citation)

1399086 Cephalosporin compounds GLAXO LABORATORIES Ltd 12 May 1972 [14 May 1971 1 Oct 1971] 15082/71 and 45884/71 Heading C2C Novel 7 - acylamidoceph - 3 - em carboxylic acids and their salts, esters and 1-sulphoxides, wherein the acylamido group has the structure in which R is hydrogen or an organi ...