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Kanji Meguro, Takeshi Fujita: Thiazolidinedione derivatives, useful as antidiabetic agents. Takeda Chemical, Wenderoth Lind & Ponack, August 18, 1987: US04687777 (169 worldwide citation)

Thiazolidinedione derivatives of the formula: ##STR1## and pharmacologically acceptable salts thereof are novel compounds, which exhibit in mammals blood sugar- and lipid-lowering activity, and are of value as a therapeutic agent for treatment of diabetes and hyperlipemia.


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Strupczewski Joseph T, Helsley Grover C, Chiang Yulin, Bordeau Kenneth J: (aryloxyalkyl)Heteroarylpiperidines and -heteroarylpiperazines,a process for their preparation and their use as medicaments.. Hoechst Roussel Pharma, December 19, 1990: EP0402644-A1 (106 worldwide citation)

This invention related to compounds of the formula: wherein X is -O-, -S-, - @H, or -@-R; p is 1 or 2; Y is hydrogen, C1 to C6 alkyl, -OH, Cl, F, Br, I, C1 to C6 alkoxy, -CF3, NO2, or -NH2, when p is 1; Y is C1 to C6 alkoxy when p is 2 and X is -O-; R is selected from the group consisting of lower a ...


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Rosenquist Åsa, Thorstensson Fredrik, Johansson Per Ola, Kvarnström Ingemar, Ayesa Susana, Classon Björn, Rakos Lazlo, Samuelsson Bertil: Hcv ns-3 serine protease inhibitors. Medivir, Tibotec Pharmaceuticals, Rosenquist Åsa, Thorstensson Fredrik, Johansson Per Ola, Kvarnström Ingemar, Ayesa Susana, Classon Björn, Rakos Lazlo, Samuelsson Bertil, AWAPATENT, August 11, 2005: WO/2005/073216 (105 worldwide citation)

Compounds of the formula (F) where the variables are as defined in the specification inhibit the NS3 protease of flavivirus sych as hepatitis C virus (HCV). The compounds comprise a novel linkage between a heterocyclic P2 unit and those portions of the inhibitor more distal to the nominal cleavage s ...


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GUO HONGYAN: Antiviral compounds. GILEAD SCIENCES, Harris Robert H, November 18, 2010: WO/2010/132601 (100 worldwide citation)

The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.


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Michael A Kuhn, Richard P Haugland, Brian M Hoyland: Benzazolylcoumarin-based ion indicators for heavy metals. Molecular Probes, Allegra J Helfenstein, Anton E Skaugset, October 17, 1995: US05459276 (99 worldwide citation)

The indicator compounds of the present invention are substituted or unsubstituted 5'-nitro-BAPTA chelators that contain a benzazolyl-coumarin substructure, and the pharmaceutically acceptable non-toxic salts and esters thereof. These compounds are useful for the detection and quantification of polyc ...


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Baker Raymond, Saunders John, Macleod Angus M, Merchant Kevin: Thiadiazoles useful in the treatment of senile dementia.. Merck Sharp & Dohme, March 15, 1989: EP0307142-A1 (96 worldwide citation)

A class of novel thiadiazoles, substituted on one of the ring carbon atoms with a non-aromatic azacyclic or azabicyclic ring system, and substituted on the other ring carbon atom with a substituent of low lipophilicity, or a hydrocarbon substituent; are potent muscarinic agonists, and have good CNS ...


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Joseph T Strupczewski: 3-(4-Piperidinyl)-1,2-benzisothiazoles. Hoechst Roussel Pharmaceuticals, Raymond R Wittekind, July 3, 1984: US04458076 (94 worldwide citation)

Novel 3-(4-piperidinyl)-1,2-benzisothiazoles, processes for the preparation thereof, and method of treating psychoses and alleviating pain employing compounds or compositions thereof are disclosed.


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David W Smith, Joseph P Yevich: Analgesic 1,2-benzisothiazol-3-ylpiperazine derivatives. Bristol Myers Company, Richard P Ryan, Robert H Uloth, May 20, 1986: US04590196 (92 worldwide citation)

A series of non-opiate analgesics of Formula I ##STR1## wherein R.sup.1 is hydrogen, alkyl, aralkyl, or aryloxyalkyl; R.sup.2 is alkyl or hydrogen; and R.sup.3 and R.sup.4 are independently selected from hydrogen, alkyl, acyloxy, alkoxy, alkylthio, halogen, hydroxyl, or trifluoromethyl; or a pharmac ...