1
Stéphane De Lombaert
Taeyoung Yoon, Ping Ge, Stéphane De Lombaert, Raymond F Horvath, Dario Doller, Kevin J Hodgetts, Lu Yan Zhang, Bernd Kaiser, Xuechun Zhang, Yasuchika Yamaguchi, Cunyu Zhang, Jim Darrow: 5-substituted-2-arylpyrazines. Neurogen Corporation, Peter F Corless, Dwight D Kim, Edwards Angell Palmer & Dodge, February 20, 2007: US07179807 (2 worldwide citation)

Novel 5-substituted-2-arylpyrazine compounds are provided. Such compounds can act as selective modulators or CRF receptors. Compounds of the invention are provided by the following formula: The 5-substituted-2-arylpyrazine compounds provided herein are useful in the treatment of a number of CNS and ...


2
Stéphane De Lombaert
Stéphane De Lombaert, Michel Jose Emmanuel: Chymase inhibitors. Boehringer Ingelheim International, Michael P Morris, Anthony P Bottino, Usha R Patel, June 5, 2012: US08193214

Disclosed are small molecule inhibitors which are useful in treating various diseases and conditions involving chymase.


3
Lee Funk
Jingrong Jean Cui, Dilip Bhumralkar, Iriny Botrous, Ji Yu Chu, Lee A Funk, Cathleen Elizabeth Hanau, G Davis Harris, Lei Jia, Joanne Johnson, Stephen A Kolodziej, Pei Pei Kung, Xiaoyuan, Jason, Jerry Jialun Meng, Mitchell David Nambu, Christopher G Nelson, Mason Alan Pairish, Hong Shen, Michelle Tran Dube, Allison Walter, Fang Jie Zhang, Jennifer Zhang: Aminoheteroaryl compounds as protein kinase inhibitors. Sugen, Foley & Lardner, June 12, 2007: US07230098 (22 worldwide citation)

Aminopyridine and aminopyrazine compounds of formula (1), compositions including these compounds, and methods of their use are provided. Preferred compounds of formula 1 have activity as protein kinase inhibitors, including as inhibitors of c-MET


4
James E Summerton, Dwight D Weller, Eugene P Stirchak: Alpha-morpholino ribonucleoside derivatives and polymers thereof. Anti Gene Development Group, Peter J Dehlinger, Gary R Fabian, August 10, 1993: US05235033 (405 worldwide citation)

Alpha-morpholino subunits and polymer compositions composed of alpha-morpholino subunits are disclosed. These subunits can be linked together by uncharged linkages, one to three atoms in length, joining the morpholino nitrogen of one subunit to the 5' exocyclic carbon of an adjacent subunit. Each su ...


5
Barker Andrew John, Brown Dearg Sutherland: Quinazoline derivatives.. Zeneca, June 22, 1994: EP0602851-A1 (147 worldwide citation)

The invention concerns quinazoline derivatives of the formula I wherein m is 1, 2 or 3 and each R includes hydroxy, amino, ureido, hydroxyamino, trifluoromethoxy, (1-4C)alkyl, (1-4C)alkoxy and (1-3C)alkylenedioxy; and and Q is a 9- or 10-membered bicyclic heterocyclic moiety containing one or two ni ...


6
Cheng Soan, Comer Daniel D, Mao Long, Balow Guity P, Pleynet David: Compouds and uses thereof in modulating amyloid beta. Torreypines Therapeutics, Cheng Soan, Comer Daniel D, Mao Long, Balow Guity P, Pleynet David, REITER Stephen E, December 23, 2004: WO/2004/110350 (145 worldwide citation)

Novel compounds, compositions, and kits are provided. Methods of modulating A&bgr; levels, and methods of treating a disease associated with aberrant A&bgr; levels are also provided.


7
Sugimoto Hachiro, Tsuchiya Yutaka, Higurashi Kunizou, Karibe Norio, Iimura Yuoichi, Sasaki Atsushi, Yamanashi Yoshiharu, Ogura Hiroo, Araki Shin Kashiwa Mansion, Kosasa Takashi, Kusota Atsuhiki, Kozasa Michiko, Yamatsu Kiyomi: Cyclic amine compound, its use and pharmaceutical compositions comprising it.. Eisai, December 28, 1988: EP0296560-A2 (141 worldwide citation)

A cyclic amine compound is defined by the formula: in which J is indanyl, indanonyl, indenyl, indenonyl, indanedionyl, tetralonyl, benzosuberonyl, indanolyl or a divalent group thereof, K is phenyl, an arylalkyl or cynnamyl, B is -(CHR22)r-, R22 being H or methyl, -CO-(CHR22)r-, =(CH-CH=CH)b-, =CH-( ...


8
Takase Yasutaka, Watanabe Nobuhisa, Matsui Makoto, Ikuta Hironori, Kimura Teiji, Saeki Takao, Adachi Hideyuki, Tokumura Tadakazu, Mochida Hisatoshi, Akita Yasunori, Souda Shigeru: Nitrogenous heterocyclic compound.. Eisai, July 27, 1994: EP0607439-A1 (120 worldwide citation)

A nitrogenous heterocyclic compound represented by general formula (I) or a pharmacologically acceptable salt thereof, efficacious in treating various ischemic cardiac diseases, wherein ring A represents a benzene, pyridine or cyclohexane ring; ring B represents a pyridine, pyrimidine or imidazole r ...


9
Carlson Randall Kent, Gregory Walter Adelman, Park Chung Ho: Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents.. Du Pont, January 31, 1990: EP0352781-A2 (112 worldwide citation)

Novel aminomethyloxooxazolidinyl arylbenzene derivatives, wherein the aryl includes the phenyl, substituted phenyl, pyridyl, and substituted pyridyl groups, such as ( l )-N-{3-[4-(4 min -pyridyl)phenyl]-2-oxooxazolidin-5-ylmethyl}acetamide, possess useful antibacterial activity.


10
Kazuo Kubo, Shinichi Ohyama, Toshiyuki Shimizu, Tsuyoshi Nishitoba, Shinichiro Kato, Hideko Murooka, Yoshiko Kobayashi: Quinoline and quinazoline derivatives inhibiting platelet-derived growth factor receptor autophosphorylation and pharmaceutical compositions containing the same. Kirin Beer Kabushiki Kaisha, Foley & Lardner, November 7, 2000: US06143764 (111 worldwide citation)

The present invention relates to novel quinoline derivatives and quinazoline derivatives represented by the following formula (I): ##STR1## [wherein R.sub.1 and R.sub.2 are each independently H or C.sub.1 -C.sub.4 -alkyl, or R.sub.1 and R.sub.2 together form C.sub.1 -C.sub.3 -alkylene, X is O, S or ...