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Kath John Charles, Luzzio Michael Joseph: Pyrimidine derivates for the treatment of abnormal cell growth. Pfizer Products, Kath John Charles, Luzzio Michael Joseph, LUMB J Trevor, July 8, 2004: WO/2004/056786 (148 worldwide citation)

The invention relates to compounds of the formula (1) and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R1, R2, R3, R4, R5, n, A and B are as defined herein. The invention also relates to methods of treating abnormal cell growth in mammals by administering the compound ...


2
Vandenberk Jan, Kennis Ludo Edmond Josephine, Van Der Aa Marcel Josef Maria, Van Heertum Albert Henricus Ma: (Piperidinylalkyl)Quinazoline derivatives, process for their preparation and pharmaceutical compositions containing them.. Janssen Pharmaceutica, July 23, 1980: EP0013612-A2 (108 worldwide citation)

Quinazoline derivatives of the formula wherein Ra is hydrogen or alkyl and and q is 2 or 3; R is hydorgen, hydroxy and alkyl; Alk is an alkylene chain having from 1 to 4 carbon atoms and Q is a quinazolinyl radical, the 1-, 2-, 3- or 4-position of which is connected with the alkylene side chain, sai ...


3
Rosenquist Åsa, Thorstensson Fredrik, Johansson Per Ola, Kvarnström Ingemar, Ayesa Susana, Classon Björn, Rakos Lazlo, Samuelsson Bertil: Hcv ns-3 serine protease inhibitors. Medivir, Tibotec Pharmaceuticals, Rosenquist Åsa, Thorstensson Fredrik, Johansson Per Ola, Kvarnström Ingemar, Ayesa Susana, Classon Björn, Rakos Lazlo, Samuelsson Bertil, AWAPATENT, August 11, 2005: WO/2005/073216 (105 worldwide citation)

Compounds of the formula (F) where the variables are as defined in the specification inhibit the NS3 protease of flavivirus sych as hepatitis C virus (HCV). The compounds comprise a novel linkage between a heterocyclic P2 unit and those portions of the inhibitor more distal to the nominal cleavage s ...


4
Strupczewski Joseph T: 3-(piperidinyl)- and 3-(pyrrolidinyl)-1h-indazoles, a process for their preparation and their use as a medicament.. Hoechst Roussel Pharma, April 3, 1985: EP0135781-A1 (103 worldwide citation)

Novel 3-(piperidinyl)- and 3-(pyrrolidinyl)-1H-indazoles, intermediates and processes for the preperation thereof, and their use for treating psychoses and alleviating pain are disclosed.


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GUO HONGYAN: Antiviral compounds. GILEAD SCIENCES, Harris Robert H, November 18, 2010: WO/2010/132601 (100 worldwide citation)

The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.


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SHORT Kevin Michael, PHAM Son Minh, WILLIAMS David Charles, DATTA Somalee: Composés aromatiques multisubstitués utilisés comme inhibiteurs de la thrombine, Multisubstituted aromatic compounds as inhibitors of thrombin. Verseon, SHORT Kevin Michael, PHAM Son Minh, WILLIAMS David Charles, DATTA Somalee, KOERBER Steven C, October 13, 2011: WO/2011/126903 (91 worldwide citation)

There are provided inter alia multisubstituted aromatic compounds useful for the inhibition of thrombin, which compounds include substituted pyrazolyl or substituted triazolyl. There are additionally provided pharmaceutical compositions. There are additionally provided methods of treating and preven ...


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Moradei Oscar, Paquin Isabelle, Leit Silvana, Frechette Sylvie, Vaisburg Arkadii, Besterman Jeffrey M, Tessier Pierre, Mallais Tammy C: Inhibitors of histone deacetylase. Methylgene, Moradei Oscar, Paquin Isabelle, Leit Silvana, Frechette Sylvie, Vaisburg Arkadii, Besterman Jeffrey M, Tessier Pierre, Mallais Tammy C, GREENFIELD Michael S, April 7, 2005: WO/2005/030705 (91 worldwide citation)

The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.


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Nakajima Suanne, Sun Ying, Tang Datong, Xu Gouyou, Porter Brian, Or Yat Sun, Wang Zhe, Miao Zhenwei: Quinoxalinyl macrocyclic hepatitis c serine protease inhibitors. Enanta Pharmaceuticals, Nakajima Suanne, Sun Ying, Tang Datong, Xu Gouyou, Porter Brian, Or Yat Sun, Wang Zhe, Miao Zhenwei, HSI Jeffrey D, November 4, 2004: WO/2004/093798 (91 worldwide citation)

The present invention relates to compounds of Formula (I) or (II), or a pharmaceutically acceptable salt, ester, or prodrug, thereof: formula (I), formula (II): which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds ...


10
Hill Christopher Huw: Process for the manufacture of substituted maleimides.. Hoffmann La Roche, May 12, 1993: EP0540956-A1 (88 worldwide citation)

The invention provides a process for the manufacture of substituted maleimides of the formula wherein R represents alkyl, aryl or heteroaryl and R represents hydrogen, alkyl, alkoxycarbonyl, aryl or heteroaryl, by reacting an activated glyoxylate of the formula wherein R has the above significance a ...