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Sugimoto Hachiro, Tsuchiya Yutaka, Higurashi Kunizou, Karibe Norio, Iimura Yuoichi, Sasaki Atsushi, Yamanashi Yoshiharu, Ogura Hiroo, Araki Shin Kashiwa Mansion, Kosasa Takashi, Kusota Atsuhiki, Kozasa Michiko, Yamatsu Kiyomi: Cyclic amine compound, its use and pharmaceutical compositions comprising it.. Eisai, December 28, 1988: EP0296560-A2 (141 worldwide citation)

A cyclic amine compound is defined by the formula: in which J is indanyl, indanonyl, indenyl, indenonyl, indanedionyl, tetralonyl, benzosuberonyl, indanolyl or a divalent group thereof, K is phenyl, an arylalkyl or cynnamyl, B is -(CHR22)r-, R22 being H or methyl, -CO-(CHR22)r-, =(CH-CH=CH)b-, =CH-( ...


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Emonds Alt Xavier, Goulaouic Pierre, Proietto Vincenzo, Van Broeck Didier: Compounds of aromatic amines and their enantiomers, process for their preparation and pharmaceutical compositions containing them.. Sanofi, May 22, 1991: EP0428434-A2 (138 worldwide citation)

The invention relates to compounds of formula in which: - m is an integer from 1 to 3; - Ar and Ar' represent, independently, a thienyl group, a substituted or unsubstituted phenyl group; an imidazolyl group; it also being possible for Ar' to be a benzothienyl group, unsubstituted or substituted wit ...


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Chandraratna Roshantha A S: Disubstituted acetylenes bearing heteroaromatic and heterobicyclic groups having retinoid like activity.. Allergan, September 28, 1988: EP0284288-A1 (135 worldwide citation)

Retinoid-like activity is exhibited by compounds of the formula where X is S, O, or NR' where R' is hydrogen or lower alkyl; R is hydrogen or lower alkyl; A is pyridyl, thienyl, furyl, pyridazinyl, pyrimidinyl or pyrazinyl; n is 0-5; and B is H, -COOH or a pharmaceutically acceptable salt, ester or ...


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Edwin Bernard Villhauer: N-(substituted glycyl)-2-cyanopyrrolidines, pharmaceutical compositions containing them and their use in inhibiting dipeptidyl peptidase-IV. Novartis, Joseph J Borovian, January 4, 2000: US06011155 (125 worldwide citation)

N-(N'-substituted glycyl)-2-cyanopyrrolidines of formula I ##STR1## Compounds of formula I inhibit DPP-IV (dipeptidyl-peptidase-IV) activity. They are therefore indicated for use as pharmaceuticals in inhibiting DPP-IV and in the treatment of conditions mediated by DPP-IV, such as non-insulin-depend ...


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Takeuchi Makoto, Naito Ryo, Morihira Koichiro, Hayakawa Masahiko, Ikeda Ken, Isomura Yasuo: Novel carbamate derivative and medicinal composition containing the same. Yamanouchi Pharma, December 11, 1996: EP0747355-A1 (125 worldwide citation)

Carbamate derivatives represented by the general formula (I), salts thereof, hydrates thereof or solvates thereof wherein each symbol has the following meaning: A ring: a benzene ring or a pyridine ring, B ring: a nitrogen-containing saturated hetero-ring which may have a substituent on the nitrogen ...


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Klaus Michael Dr, Weiser Harald Dr, Loeliger Peter Dr: Heterocyclic compounds and rodenticides containing them.. Hoffmann La Roche, January 18, 1984: EP0098591-A1 (110 worldwide citation)

Verbindungen der allgemeinen Formel worin X -CH = CH-, -O- oder -S- ist; R ein Rest Ar-R oder -CH = CH-C(CH3) = CH-R; Ar Phenyl, Pyridyl, Furyl oder Thienyl; R ein Rest -CO2R , -C(O)R, -CH2OR , nieder-Alkylsulfonyl oder Formyl; R ein Rest -CO2R , -C(O)R, -CH2OR oder Formyl; R Wasserstoff oder nieder ...


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Vandenberk Jan, Kennis Ludo Edmond Josephine, Van Der Aa Marcel Josef Maria, Van Heertum Albert Henricus Ma: (Piperidinylalkyl)Quinazoline derivatives, process for their preparation and pharmaceutical compositions containing them.. Janssen Pharmaceutica, July 23, 1980: EP0013612-A2 (108 worldwide citation)

Quinazoline derivatives of the formula wherein Ra is hydrogen or alkyl and and q is 2 or 3; R is hydorgen, hydroxy and alkyl; Alk is an alkylene chain having from 1 to 4 carbon atoms and Q is a quinazolinyl radical, the 1-, 2-, 3- or 4-position of which is connected with the alkylene side chain, sai ...


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Van Daele Georges: Novel n-(3-hydroxy-4-piperidinyl)benzamide derivatives.. Janssen Pharmaceutica, April 13, 1983: EP0076530-A2 (107 worldwide citation)

Novel N-(4-piperidinyl)benzamides of the formula and the pharmaceutically acceptable acid addition salts, the stereochemically isomeric forms and the pharmaceutically acceptable quaternary ammonium salts thereof, which compounds are useful as stimulators of the motility of the gastro-intestinal syst ...


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Scott A Biller, John K Dickson, R Michael Lawrence, David R Magnin, Michael A Poss, Richard B Sulsky, Joseph A Tino: Inhibitors of microsomal triglyceride transfer protein and method. Bristol Myers Squibb Company, Burton Rodney, April 14, 1998: US05739135 (103 worldwide citation)

Compounds are provided which inhibit microsomal triglyceride transfer protein and thus are useful for lowering serum lipids and treating atherosclerosis and related diseases. The compounds have the structure ##STR1## wherein R.sup.1 to R.sup.7, Q, X and Y are as defined herein.