1
Tsuboyama Akira, Mizutani Hidemasa, Okada Shinjiro, Takiguchi Takao, Miura Seishi, Moriyama Takashi, Igawa Satoshi, Kamatani Jun, Furugori Manabu: Luminescence device and display apparatus. Canon, March 27, 2002: EP1191612-A2 (155 worldwide citation)

A luminescence device is principally constituted by a pair of electrodes and an organic compound layer disposed therebetween. The layer contains a metal coordination compound represented by the following formula (1): wherein M denotes Ir, Rh or Pd; n is 2 or 3; CyN denotes a substituted or unsubstit ...


2
Britcher Susan F, Lumma William C Jr, Goldman Mark E, Lyle Terry A, Huff Joel R, Payne Linda S, Quesada Martha L, Young Steven D, Sanders William M, Sanderson Philip E, Tucker Thomas J: Quinazoline derivatives as inhibitors of hiv reverse transcriptase.. Merck & Co, March 10, 1993: EP0530994-A1 (146 worldwide citation)

Compounds having a quinazolin-2-(thi)one nucleus are described. These compounds are useful in the inhibition of HIV reverse transcriptase, the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ing ...


3
Hayakawa Masahiko, Kaizawa Hiroyuki, Moritomo Hiroyuki, Kawaguchi Ken Ichi, Koizumi Tomonobu, Yamano Mayumi, Matsuda Koyo, Okada Minoru, Ohta Mitsuaki: Condensed heteroaryl derivatives. Yamanouchi Pharma, Ludwig Inst Cancer Res, Imp Cancer Res Tech, January 22, 2003: EP1277738-A1 (120 worldwide citation)

The present invention provides a pharmaceutical composition which is useful as a phosphatidylinositol 3 kinase (PI3K) inhibitor and an antitumor agent, and it provides a novel bicyclic or tricyclic fused heteroaryl derivative or a salt thereof which possesses an excellent PI3K inhibiting activity an ...


4
Goulaouic Pierre, Emonds Alt Xavier, Gueule Patrick, Proietto Vincenzo: Aminated polycyclic compounds and their enantiomers, process for their preparation and pharmaceutical compositions containing them.. Sanofi Elf, November 11, 1992: EP0512901-A1 (103 worldwide citation)

The invention relates to compounds of formula (I): in which - Y represents - either a Cy-N or Cy-CH2-N group in which Cy represents an optionally substituted phenyl; - or a group in which .Ar represents an optionally substituted phenyl; .x is zero or one; .X represents a hydrogen, a hydroxyl, an alk ...


5
Hill Christopher Huw: Process for the manufacture of substituted maleimides.. Hoffmann La Roche, May 12, 1993: EP0540956-A1 (88 worldwide citation)

The invention provides a process for the manufacture of substituted maleimides of the formula wherein R represents alkyl, aryl or heteroaryl and R represents hydrogen, alkyl, alkoxycarbonyl, aryl or heteroaryl, by reacting an activated glyoxylate of the formula wherein R has the above significance a ...


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Mansour Tarek, Hin Haolun, Tse Allan H L, Siddiqui Arshad M: Processes for the diastereo-selective synthesis of nucleosides.. Iaf Biochem Int, November 25, 1992: EP0515156-A1 (88 worldwide citation)

The present invention relates to highly diastereoselective processes for production of cis-nucleotides and nucleoside analogues and derivatives in high optical purity and intermediates useful in those processes.


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Wahhab Amal, Therrien Eric, Allan Martin, Manku Sukhdev: Small molecule inhibitors of protein arginine methyltransferases (prmts). Methylgene, Wahhab Amal, Therrien Eric, Allan Martin, Manku Sukhdev, BERESKIN 40th floor 40 King Street West Toronto Ontario M5H 3Y2, September 4, 2008: WO/2008/104077 (87 worldwide citation)

The present invention relates to compounds that are useful as inhibitors of protein arginine methyltransferase that have a formula selected from Formula (I), Formula (II) and Formula (III), as well as racemic mixtures, diastereomers, enantiomers and tautomers thereof and N-oxides, hydrates, solvates ...


8
Matsuo Masaaki, Tsuji Kiyoshi, Konishi Nobukiyo, Nakamura Katsuya: Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same.. Fujisawa Pharmaceutical Co, March 27, 1991: EP0418845-A1 (82 worldwide citation)

A compound of the formula : wherein R is aryl which may be substituted with substituent(s) selected from the group consisting of lower alkyl, halogen, lower alkoxy, lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, hydroxy, lower alkylsulfonyloxy, nitro, amino, lower alkylamino, acylamino a ...


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Torley Lawrence Wayne, Johnson Bernard B, Dusza John Paul: 4,5,6-substituted-2-pyrimidinamines.. American Cyanamid Co, August 26, 1987: EP0233461-A2 (79 worldwide citation)

This disclosure describes novel 4,5,6-substituted-N-(substituted-phenyl)-2-pyrimidinamines having anti-asthmatic activity.