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James Doherty
Dorn Conrad P, Finke Paul E, Maccoss Malcolm, Doherty James B, Shah Shrenik K, Hagmann William K: New substituted azetidinones as anti-inflammatory and antidegenerative agents.. Merck & Co, April 22, 1992: EP0481671-A1 (40 worldwide citation)

New substituted azetidinones of the general formula (A') which have been found to be potent elastase inhibitors and thereby useful anti-inflammatory and antidegenerative agents are described. e


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Hoffman William Wheeler, Kraska Allen Richard: Carboxylic acid derivatives useful for inhibiting the degradation of cartilage.. Pfizer, January 9, 1985: EP0130795-A2 (154 worldwide citation)

Certain carboxylic acids of the formula and the pharmaceutically-acceptable salts thereof, and certain esters and amides thereof, are useful for inhibiting the degradation of articular cartilage when administered to a mammalian subject afflicted with an arthritic disease. X is O, S, SO, SO2, NH, NCH ...


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Sugimoto Hachiro, Tsuchiya Yutaka, Higurashi Kunizou, Karibe Norio, Iimura Yuoichi, Sasaki Atsushi, Yamanashi Yoshiharu, Ogura Hiroo, Araki Shin Kashiwa Mansion, Kosasa Takashi, Kusota Atsuhiki, Kozasa Michiko, Yamatsu Kiyomi: Cyclic amine compound, its use and pharmaceutical compositions comprising it.. Eisai, December 28, 1988: EP0296560-A2 (141 worldwide citation)

A cyclic amine compound is defined by the formula: in which J is indanyl, indanonyl, indenyl, indenonyl, indanedionyl, tetralonyl, benzosuberonyl, indanolyl or a divalent group thereof, K is phenyl, an arylalkyl or cynnamyl, B is -(CHR22)r-, R22 being H or methyl, -CO-(CHR22)r-, =(CH-CH=CH)b-, =CH-( ...


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Emonds Alt Xavier, Goulaouic Pierre, Proietto Vincenzo, Van Broeck Didier: Compounds of aromatic amines and their enantiomers, process for their preparation and pharmaceutical compositions containing them.. Sanofi, May 22, 1991: EP0428434-A2 (138 worldwide citation)

The invention relates to compounds of formula in which: - m is an integer from 1 to 3; - Ar and Ar' represent, independently, a thienyl group, a substituted or unsubstituted phenyl group; an imidazolyl group; it also being possible for Ar' to be a benzothienyl group, unsubstituted or substituted wit ...


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Hayakawa Masahiko, Kaizawa Hiroyuki, Moritomo Hiroyuki, Kawaguchi Ken Ichi, Koizumi Tomonobu, Yamano Mayumi, Matsuda Koyo, Okada Minoru, Ohta Mitsuaki: Condensed heteroaryl derivatives. Yamanouchi Pharma, Ludwig Inst Cancer Res, Imp Cancer Res Tech, January 22, 2003: EP1277738-A1 (120 worldwide citation)

The present invention provides a pharmaceutical composition which is useful as a phosphatidylinositol 3 kinase (PI3K) inhibitor and an antitumor agent, and it provides a novel bicyclic or tricyclic fused heteroaryl derivative or a salt thereof which possesses an excellent PI3K inhibiting activity an ...


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Takase Yasutaka, Watanabe Nobuhisa, Matsui Makoto, Ikuta Hironori, Kimura Teiji, Saeki Takao, Adachi Hideyuki, Tokumura Tadakazu, Mochida Hisatoshi, Akita Yasunori, Souda Shigeru: Nitrogenous heterocyclic compound.. Eisai, July 27, 1994: EP0607439-A1 (120 worldwide citation)

A nitrogenous heterocyclic compound represented by general formula (I) or a pharmacologically acceptable salt thereof, efficacious in treating various ischemic cardiac diseases, wherein ring A represents a benzene, pyridine or cyclohexane ring; ring B represents a pyridine, pyrimidine or imidazole r ...


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