The present invention provides arylpiperazine derivatives which can be advantageously used for treating schizophrenia and related psychoses such as acute manic, bipolar disorder, autistic disorder, and depression.
Substituted imidazoles such as are useful as angiotensin II blockers. These compounds have activity in treating hypertension and congestive heart failure.
The invention encompasses a pharmaceutical composition comprising a diuretic or a non-steroidal antiinflammatory drug, a pharmaceutical suitable carrier and an antihypertensive and processes for production of these compositions.
The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.
Compounds having the structure of formula I are described. The compounds can inhibit hepatitis C virus (HCV) replication, and in particular can inhibit the function of the HCV NS5A protein.
Substituted imidazoles such as ##STR1## are useful as angiotensin II blockers. These compounds have activity in treating hypertension and congestive heart failure.
Novel cytotoxic agents comprising a cell binding agent chemically linked to one or more analogue or derivative of CC-1065 are described. The therapeutic use of the cytotoxic agents is also described. These cytotoxic agents have therapeutic use because they deliver the cytotoxic drugs to a specific c ...
(2,3,3-Trimethyl-3-H-indol-5-yl)-acetic acid has been synthesized. Additionally, derivatives of (2,3,3-Trimethyl-3-H-indol-5-yl)-acetic acid have been prepared as intermediates for preparation of fluorescent cyanine biolabels. A derived dye, 5.5'-Dicarboxymethyl-3,3,3',3'-tetramethyl-1,1'-diethylind ...
A metal catalyzed click chemistry ligation process is employed to bind azides and terminal acetylenes to give triazoles. In many instances, the reaction sequence regiospecifically ligates azides and terminal acetylenes to give only 1,4-disubstituted [1,2,3]-triazoles.